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Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33003-7
By:
- Lamers, Christina;
- Xue, Xiaoguang;
- Smieško, Martin;
- van Son, Henri;
- Wagner, Bea;
- Berger, Nadja;
- Sfyroera, Georgia;
- Gros, Piet;
- Lambris, John D.;
- Ricklin, Daniel
Publication type:
Article
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma.
Published in:
2006
By:
- Köhl, Jörg;
- Baelder, Ralf;
- Lewkowich, Ian P.;
- Pandey, Manoj K.;
- Hawlisch, Heiko;
- Lihua Wang;
- Best, Jennifer;
- Herman, Nancy S.;
- Sproles, Alyssa A.;
- Zwirner, Jörg;
- Whitsett, Jeffrey A.;
- Gerard, Craig;
- Sfyroera, Georgia;
- Lambris, John D.;
- Wills-Karp, Marsha;
- Köhl, Jörg;
- Wang, Lihua;
- Zwirner, Jörg
Publication type:
journal article
Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement.
Published in:
eLife, 2020, p. 1, doi. 10.7554/eLife.60908
By:
- Jie Zhang;
- Lihong Song;
- Pedersen, Dennis V.;
- Li, Anna;
- Lambris, John D.;
- Andersen, Gregers Rom;
- Mollnes, Tom Eirik;
- Ying Jie Ma;
- Garred, Peter
Publication type:
Article
Complement modulation reverses pathology in Y402H‐retinal pigment epithelium cell model of age‐related macular degeneration by restoring lysosomal function.
Published in:
Stem Cells Translational Medicine, 2020, v. 9, n. 12, p. 1585, doi. 10.1002/sctm.20-0211
By:
- Cerniauskas, Edvinas;
- Kurzawa‐Akanbi, Marzena;
- Xie, Long;
- Hallam, Dean;
- Moya‐Molina, Marina;
- White, Kathryn;
- Steel, David;
- Doherty, Mary;
- Whitfield, Phil;
- Al‐Aama, Jumana;
- Armstrong, Lyle;
- Kavanagh, David;
- Lambris, John D.;
- Korolchuk, Viktor I.;
- Harris, Claire;
- Lako, Majlinda
Publication type:
Article
Bothrops jararaca Snake Venom Inflammation Induced in Human Whole Blood: Role of the Complement System.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.885223
By:
- Thyago Bispo Leonel;
- Megale Gabrili, Joel José;
- Cristina Squaiella-Baptistão, Carla;
- Woodruff, Trent M.;
- Lambris, John D.;
- Tambourgi, Denise V.
Publication type:
Article
C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25745-7
By:
- Schmitz, Robin;
- Fitch, Zachary W.;
- Schroder, Paul M.;
- Choi, Ashley Y.;
- Manook, Miriam;
- Yoon, Janghoon;
- Song, Mingqing;
- Yi, John S.;
- Khandelwal, Sanjay;
- Arepally, Gowthami M.;
- Farris, Alton B.;
- Reis, Edimara S.;
- Lambris, John D.;
- Kwun, Jean;
- Knechtle, Stuart J.
Publication type:
Article
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24021-y
By:
- Doni, Andrea;
- Parente, Raffaella;
- Laface, Ilaria;
- Magrini, Elena;
- Cunha, Cristina;
- Colombo, Federico Simone;
- Lacerda, João F.;
- Campos, António;
- Mapelli, Sarah N.;
- Petroni, Francesca;
- Porte, Rémi;
- Schorn, Tilo;
- Inforzato, Antonio;
- Mercier, Toine;
- Lagrou, Katrien;
- Maertens, Johan;
- Lambris, John D.;
- Bottazzi, Barbara;
- Garlanda, Cecilia;
- Botto, Marina
Publication type:
Article
Complement-targeted therapeutics.
Published in:
Nature Biotechnology, 2007, v. 25, n. 11, p. 1265, doi. 10.1038/nbt1342
By:
- Ricklin, Daniel;
- Lambris, John D.
Publication type:
Article
Do Cryopreserved Mesenchymal Stromal Cells Display Impaired Immunomodulatory and Therapeutic Properties?
Published in:
Stem Cells, 2014, v. 32, n. 9, p. 2430, doi. 10.1002/stem.1729
By:
- Moll, Guido;
- Alm, Jessica J.;
- Davies, Lindsay C.;
- von Bahr, Lena;
- Heldring, Nina;
- Stenbeck-Funke, Lillemor;
- Hamad, Osama A.;
- Hinsch, Robin;
- Ignatowicz, Lech;
- Locke, Matthew;
- Lönnies, Helena;
- Lambris, John D.;
- Teramura, Yuji;
- Nilsson-Ekdahl, Kristina;
- Nilsson, Bo;
- Blanc, Katarina
Publication type:
Article
A sweet spot to control complement-induced inflammation.
Published in:
Nature Medicine, 2012, v. 18, n. 9, p. 1340, doi. 10.1038/nm.2916
By:
- Ricklin, Daniel;
- Reis, Edimara S;
- Lambris, John D
Publication type:
Article
Generation of C5a in the absence of C3: a new complement activation pathway.
Published in:
Nature Medicine, 2006, v. 12, n. 6, p. 682, doi. 10.1038/nm1419
By:
- Huber-Lang, Markus;
- Sarma, J. Vidya;
- Zetoune, Firas S.;
- Rittirsch, Daniel;
- Neff, Thomas A.;
- McGuire, Stephanie R.;
- Lambris, John D.;
- Warner, Roscoe L.;
- Flierl, Michael A.;
- Hoesel, Laszlo M.;
- Gebhard, Florian;
- Younger, John G.;
- Drouin, Scott M.;
- Wetsel, Rick A.;
- Ward, Peter A.
Publication type:
Article
Development of a New Pharmacophore Model That Discriminates Active Compstatin Analogs.
Published in:
Chemical Biology & Drug Design, 2008, v. 72, n. 4, p. 249, doi. 10.1111/j.1747-0285.2008.00709.x
By:
- Ting-Lan Chiu;
- Mulakala, Chandrika;
- Lambris, John D.;
- Kaznessis, Yiannis N.
Publication type:
Article
Complement‐targeted therapeutics: An emerging field enabled by academic drug discovery.
Published in:
American Journal of Hematology, 2023, v. 98, p. S82, doi. 10.1002/ajh.26875
By:
- Lamers, Christina;
- Ricklin, Daniel;
- Lambris, John D.
Publication type:
Article
Factor h c-Terminal Domains are critical for regulation of Platelet/granulocyte aggregate Formation.
Published in:
Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01586
By:
- Blatt, Adam Z.;
- Saggu, Gurpanna;
- Cortes, Claudio;
- Herbert, Andrew P.;
- Kavanagh, David;
- Ricklin, Daniel;
- Lambris, John D.;
- Ferreira, Viviana P.
Publication type:
Article
The Evolution and Appearance of C3 Duplications in Fish Originate an Exclusive Teleost <i>c3</i> Gene Form with Anti-Inflammatory Activity.
Published in:
PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0099673
By:
- Forn-Cuní, Gabriel;
- Reis, Edimara S.;
- Dios, Sonia;
- Posada, David;
- Lambris, John D.;
- Figueras, Antonio;
- Novoa, Beatriz
Publication type:
Article
Regulation of Immune Responsiveness <i>In Vivo</i> by Disrupting an Early T-Cell Signaling Event Using a Cell-Permeable Peptide
Published in:
PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0063645
By:
- Guimond, David M.;
- Cam, Nicholas R.;
- Hirve, Nupura;
- Duan, Wei;
- Lambris, John D.;
- Croft, Michael;
- Tsoukas, Constantine D.
Publication type:
Article
Mesenchymal Stromal Cells Engage Complement and Complement Receptor Bearing Innate Effector Cells to Modulate Immune Responses.
Published in:
PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0021703
By:
- Moll, Guido;
- Jitschin, Regina;
- Bahr, Lena von;
- Rasmusson-Duprez, Ida;
- Sundberg, Berit;
- Lönnies, Lena;
- Elgue, Graciela;
- Nilsson-Ekdahl, Kristina;
- Mougiakakos, Dimitrios;
- Lambris, John D.;
- Ringdén, Olle;
- Blanc, Katarina Le;
- Nilsson, Bo
Publication type:
Article
Contribution of Chondroitin Sulfate A to the Binding of Complement Proteins to Activated Platelets.
Published in:
PLoS ONE, 2010, v. 5, n. 9, p. 1, doi. 10.1371/journal.pone.0012889
By:
- Hamad, Osama A.;
- Nilsson, Per H.;
- Lasaosa, Maria;
- Ricklin, Daniel;
- Lambris, John D.;
- Nilsson, Bo;
- Ekdahl, Kristina Nilsson
Publication type:
Article
Conformational interconversion in compstatin probed with molecular dynamics simulations.
Published in:
Proteins, 2003, v. 53, n. 1, p. 130, doi. 10.1002/prot.10491
By:
- Buddhadeb Mallik;
- John D. Lambris;
- Dimitrios Morikis
Publication type:
Article
Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex.
Published in:
2016
By:
- Gustavsen, Alice;
- Nymo, Stig;
- Landsem, Anne;
- Christiansen, Dorte;
- Ryan, Liv;
- Husebye, Harald;
- Lau, Corinna;
- Pischke, Søren E.;
- Lambris, John D.;
- Espevik, Terje;
- Mollnes, Tom E.
Publication type:
journal article
Blood protein-polymer adsorption: Implications for understanding complement-mediated hemoincompatibility.
Published in:
Journal of Biomedical Materials Research, Part A, 2011, v. 97A, n. 1, p. 74, doi. 10.1002/jbm.a.33030
By:
- Engberg, Anna E.;
- Rosengren-Holmberg, Jenny P.;
- Chen, Hui;
- Nilsson, Bo;
- Lambris, John D.;
- Nicholls, Ian A.;
- Ekdahl, Kristina N.
Publication type:
Article
Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis.
Published in:
2022
By:
- Gonçales, Relber A.;
- Novais Bastos, Helder;
- Duarte-Oliveira, Cláudio;
- Antunes, Daniela;
- Sokhatska, Oksana;
- Jacob, Maria;
- Rolo, Rui;
- Campos, Cláudia F.;
- Sasaki, Sergio D.;
- Donato, Alessia;
- Mapelli, Sarah N.;
- Costa, Sandra;
- Souto Moura, Conceição;
- Delgado, Luís;
- Morais, António;
- Torrado, Egídio;
- van de Veerdonk, Frank L.;
- Weichhart, Thomas;
- Lambris, John D.;
- Silvestre, Ricardo
Publication type:
journal article
Partial hepatectomy induced liver proteome changes in mice.
Published in:
Proteomics, 2005, v. 5, n. 1, p. 318, doi. 10.1002/pmic.200400913
By:
- Christoph W. Strey;
- Mike S. Winters;
- Maciej M. Markiewski;
- John D. Lambris
Publication type:
Article
The Challenges and Promise of Complement Therapeutics for Ocular Diseases.
Published in:
Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01007
By:
- Park, Dong Ho;
- Connor, Kip M.;
- Lambris, John D.
Publication type:
Article
Corrigendum: Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction.
Published in:
2019
By:
- Karasu, Ebru;
- Nilsson, Bo;
- Köhl, Jörg;
- Lambris, John D.;
- Huber-Lang, Markus
Publication type:
Correction Notice
Complement-Dependent Mechanisms and Interventions in Periodontal Disease.
Published in:
Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00406
By:
- Hajishengallis, George;
- Kajikawa, Tetsuhiro;
- Hajishengallis, Evlambia;
- Maekawa, Tomoki;
- Reis, Edimara S.;
- Mastellos, Dimitrios C.;
- Yancopoulou, Despina;
- Hasturk, Hatice;
- Lambris, John D.
Publication type:
Article
Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model.
Published in:
International Journal of Nanomedicine, 2017, v. 12, p. 3927, doi. 10.2147/IJN.S136453
By:
- Wolf-Grosse, Susann;
- Rokstad, Anne Mari;
- Ali, Syed;
- Lambris, John D.;
- Mollnes, Tom E.;
- Nilsen, Asbjørn M.;
- Stenvik, Jørgen
Publication type:
Article
Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.
Published in:
EMBO Journal, 2016, v. 35, n. 10, p. 1133, doi. 10.15252/embj.201593673
By:
- Forneris, Federico;
- Wu, Jin;
- Xue, Xiaoguang;
- Ricklin, Daniel;
- Lin, Zhuoer;
- Sfyroera, Georgia;
- Tzekou, Apostolia;
- Volokhina, Elena;
- Granneman, Joke CM;
- Hauhart, Richard;
- Bertram, Paula;
- Liszewski, M Kathryn;
- Atkinson, John P;
- Lambris, John D;
- Gros, Piet
Publication type:
Article
Acute Lung Injury and Fibrosis in a Baboon Model of Escherichia coli Sepsis.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2014, v. 50, n. 2, p. 439, doi. 10.1165/rcmb.2013-0219OC
By:
- Keshari, Ravi S.;
- Silasi-Mansat, Robert;
- Hua Zhu;
- Popescu, Narcis I.;
- Peer, Glenn;
- Chaaban, Hala;
- Lambris, John D.;
- Polf, Holly;
- Lupu, Cristina;
- Kinasewitz, Gary;
- Lupu, Florea
Publication type:
Article
C3a receptor antagonist attenuates brain injury after intracerebral hemorrhage.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 2009, v. 29, n. 1, p. 98, doi. 10.1038/jcbfm.2008.95
By:
- Rynkowski, Michal A.;
- Kim, Grace H.;
- Garrett, Matthew C.;
- Zacharia, Brad E.;
- Otten, Marc L.;
- Sosunov, Sergei A.;
- Komotar, Ricardo J.;
- Hassid, Benjamin G.;
- Ducruet, Andrew F.;
- Lambris, John D.;
- Connolly, E. Sander
Publication type:
Article
Structure of C3b reveals conformational changes that underlie complement activity.
Published in:
Nature, 2006, v. 444, n. 7116, p. 213, doi. 10.1038/nature05172
By:
- Janssen, Bert J. C.;
- Christodoulidou, Agni;
- McCarthy, Andrew;
- Lambris, John D.;
- Gros, Piet
Publication type:
Article
Microbial manipulation of receptor crosstalk in innate immunity.
Published in:
2011
By:
- Hajishengallis, George;
- Lambris, John D.
Publication type:
journal article
Complement Inhibition Prevents Oncolytic Vaccinia Virus Neutralization in Immune Humans and Cynomolgus Macaques.
Published in:
Molecular Therapy, 2015, v. 23, n. 6, p. 1066, doi. 10.1038/mt.2015.49
By:
- Evgin, Laura;
- Acuna, Sergio A;
- Tanese de Souza, Christiano;
- Marguerie, Monique;
- Lemay, Chantal G;
- Ilkow, Carolina S;
- Findlay, C Scott;
- Falls, Theresa;
- Parato, Kelley A;
- Hanwell, David;
- Goldstein, Alyssa;
- Lopez, Roberto;
- Lafrance, Sandra;
- Breitbach, Caroline J;
- Kirn, David;
- Atkins, Harold;
- Auer, Rebecca C;
- Thurman, Joshua M;
- Stahl, Gregory L;
- Lambris, John D
Publication type:
Article
Protection of host cells by complement regulators.
Published in:
Immunological Reviews, 2016, v. 274, n. 1, p. 152, doi. 10.1111/imr.12475
By:
- Schmidt, Christoph Q.;
- Lambris, John D.;
- Ricklin, Daniel
Publication type:
Article
Preformed mediators of defense-Gatekeepers enter the spotlight.
Published in:
Immunological Reviews, 2016, v. 274, n. 1, p. 5, doi. 10.1111/imr.12497
By:
- Ricklin, Daniel;
- Lambris, John D.
Publication type:
Article
More than complementing Tolls: complement-Toll-like receptor synergy and crosstalk in innate immunity and inflammation.
Published in:
Immunological Reviews, 2016, v. 274, n. 1, p. 233, doi. 10.1111/imr.12467
By:
- Hajishengallis, George;
- Lambris, John D.
Publication type:
Article
Complement component C3 - The 'Swiss Army Knife' of innate immunity and host defense.
Published in:
Immunological Reviews, 2016, v. 274, n. 1, p. 33, doi. 10.1111/imr.12500
By:
- Ricklin, Daniel;
- Reis, Edimara S.;
- Mastellos, Dimitrios C.;
- Gros, Piet;
- Lambris, John D.
Publication type:
Article
Structure and biology of complement protein C3, a connecting link between innate and acquired immunity.
Published in:
Immunological Reviews, 2001, v. 180, n. 1, p. 35, doi. 10.1034/j.1600-065x.2001.1800103.x
By:
- Sahu, Arvind;
- Lambris, John D.
Publication type:
Article
Evolution and diversity of the complement system of poikilothermic vertebrates.
Published in:
Immunological Reviews, 1998, v. 166, n. 1, p. 39, doi. 10.1111/j.1600-065X.1998.tb01251.x
By:
- Sunyer, J. Oriol;
- Lambris, John D.
Publication type:
Article
In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model.
Published in:
Frontiers in Immunology, 2023, v. 14, p. 01, doi. 10.3389/fimmu.2023.1101387
By:
- Gerogianni, Alexandra;
- Bal, Melissa;
- Mohlin, Camilla;
- Woodruff, Trent M.;
- Lambris, John D.;
- Mollnes, Tom E.;
- Sjöström, Dick J.;
- Nilsson, Per H.
Publication type:
Article
The Complement System Is Critical in Maintaining Retinal Integrity during Aging.
Published in:
Frontiers in Aging Neuroscience, 2018, p. 1, doi. 10.3389/fnagi.2018.00015
By:
- Mukai, Ryo;
- Okunuki, Yoko;
- Husain, Deeba;
- Kim, Clifford B.;
- Lambris, John D.;
- Connor, Kip M.
Publication type:
Article
Complement inhibition decreases early fibrogenic events in the lung of septic baboons.
Published in:
Journal of Cellular & Molecular Medicine, 2015, v. 19, n. 11, p. 2549, doi. 10.1111/jcmm.12667
By:
- Silasi‐Mansat, Robert;
- Zhu, Hua;
- Georgescu, Constantin;
- Popescu, Narcis;
- Keshari, Ravi S.;
- Peer, Glenn;
- Lupu, Cristina;
- Taylor, Fletcher B.;
- Pereira, Heloise Anne;
- Kinasewitz, Gary;
- Lambris, John D.;
- Lupu, Florea
Publication type:
Article
Complexity of complement activation in sepsis.
Published in:
Journal of Cellular & Molecular Medicine, 2008, v. 12, n. 6a, p. 2245, doi. 10.1111/j.1582-4934.2008.00504.x
By:
- Markiewski, Maciej M.;
- DeAngelis, Robert A.;
- Lambris, John D.
Publication type:
Article
The alternative complement pathway regulates pathological angiogenesis in the retina.
Published in:
FASEB Journal, 2014, v. 28, n. 7, p. 3171, doi. 10.1096/fj.14-251041
By:
- Sweigard, J. Harry;
- Ryoji Yanai;
- Gaissert, Philipp;
- Saint-Geniez, Magali;
- Kataoka, Keiko;
- Thanos, Aristomenis;
- Stahl, Gregory L.;
- Lambris, John D.;
- Connor, Kip M.
Publication type:
Article
Inhibition of biomaterial-induced complement activation attenuates the inflammatory host response to implantation.
Published in:
FASEB Journal, 2013, v. 27, n. 7, p. 2768, doi. 10.1096/fj.12-225888
By:
- Kourtzelis, Ioannis;
- Rafail, Stavros;
- DeAngelis, Robert A.;
- Foukas, Periklis G.;
- Ricklin, Daniel;
- Lambris, John D.
Publication type:
Article
Is complement the culprit behind COVID-19 vaccine-related adverse reactions?
Published in:
2021
By:
- Mastellos, Dimitrios C.;
- Skendros, Panagiotis;
- Lambris, John D.
Publication type:
journal article
Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis.
Published in:
2020
By:
- Skendros, Panagiotis;
- Mitsios, Alexandros;
- Chrysanthopoulou, Akrivi;
- Mastellos, Dimitrios C.;
- Metallidis, Simeon;
- Rafailidis, Petros;
- Ntinopoulou, Maria;
- Sertaridou, Eleni;
- Tsironidou, Victoria;
- Tsigalou, Christina;
- Tektonidou, Maria;
- Konstantinidis, Theocharis;
- Papagoras, Charalampos;
- Mitroulis, Ioannis;
- Germanidis, Georgios;
- Lambris, John D.;
- Ritis, Konstantinos;
- Tektonidou, Maria G
Publication type:
journal article
Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1β.
Published in:
Journal of Cellular Biochemistry, 2011, v. 112, n. 9, p. 2594, doi. 10.1002/jcb.23186
By:
- Ignatius, Anita;
- Schoengraf, Philipp;
- Kreja, Ludwika;
- Liedert, Astrid;
- Recknagel, Stefan;
- Kandert, Sebastian;
- Brenner, Rolf E.;
- Schneider, Marion;
- Lambris, John D.;
- Huber-Lang, Markus
Publication type:
Article
A 'rule of 3' to revive Greek science, research and innovation.
Published in:
Nature Immunology, 2015, v. 16, n. 12, p. 1206, doi. 10.1038/ni.3322
By:
- Kollias, George;
- Lambris, John D
Publication type:
Article
Aegean reflections on innate immunity.
Published in:
Nature Immunology, 2013, v. 14, n. 10, p. 1025, doi. 10.1038/ni.2690
By:
- Hajishengallis, George;
- Mantovani, Alberto;
- Moretta, Alessandro;
- Lambris, John D
Publication type:
Article

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