New score including daily life independence levels with dementia is associated with the onset of deep vein thrombosis in frail older adults.

Nakanishi, Keisuke; Kanda, Tsugiyasu; Kobata, Takashi; Mori, Masayuki; Yamada, Shinya; Kasamaki, Yuji

Aim: The detailed risk factors of deep vein thrombosis (DVT) remain unknown, and no efficient tool to assess the risk of the development of DVT among older adults has been established. This study aimed to clarify the risk factors, including the level of daily life independence, and develop an assessment score for DVT in older patients. Methods: We recruited 252 patients aged ≧65 years with suspected deep vein thrombosis. Risk factors for deep vein thrombosis, cognitive impairment, laboratory data and level of daily life independence were analyzed to calculate the odds ratios for the onset of DVT with logistic regressions. The Himi score was generated with factors significantly related to DVT by adjusting the respective odds ratios. The discrimination accuracy of the Himi score associated with the onset of DVT was compared with those of conventional scores (Wells score, Padua score) based on the area under the receiver operating characteristic curve. Results: Low levels of daily life independence, D‐dimer level >3.0 μg/mL, anticoagulant use, cancer and immobilization or symptoms of the lower limbs were associated with the onset of DVT. The discrimination accuracy of Himi scores composed of these related factors was significantly higher than those of the Wells and Padua scores. Conclusions: Achieving a better performance than did the Wells and Padua scores, the Himi score could be used to assess the risk of DVT in frail older adults. Geriatr Gerontol Int 2020; 20: 414–421.

JAPAN; VENOUS thrombosis risk factors; PSYCHOLOGICAL aspects of aging; DEMENTIA; RISK assessment; TUMORS; LOGISTIC regression analysis; ACTIVITIES of daily living; RECEIVER operating characteristic curves; FIBRIN fibrinogen degradation products; ODDS ratio

Geriatrics & Gerontology International, 2020, Vol 20, Issue 5, p414

1444-1586

Academic Journal

10.1111/ggi.13873