Precipitation of sugammadex with nicardipine and labetalol: A laboratory research.

Han, Jiwon; Oh, Ah‐Young

There is a paucity of clinical data about whether sugammadex forms precipitates with other medications. This laboratory experimental study was performed to determine the drugs that produce precipitates with sugammadex. Samples of 1 ml of sugammadex were prepared in transparent cylinders, to which 1 ml of test drugs (rocuronium, neostigmine, glycopyrrolate, atropine, nitroglycerin, dobutamine, dopamine, epinephrine, vasopressin, norepinephrine, phenylephrine, ephedrine, esmolol, nicardipine, and labetalol) was added. The precipitation reaction was observed visually and via light microscope. The pH of each drugs before and after mixing with sugammadex was measured. White crystals were formed when sugammadex was mixed with nicardipine or labetalol. Sugammadex formed precipitate when mixed with nicardipine or labetalol. Sufficient fluid flushing is required between injections of each drug to prevent these reactions.

SUGAMMADEX; ATROPINE; LABETALOL; PRECIPITATION (Chemistry); DOPAMINE; GLYCOPYRROLATE; ROCURONIUM bromide; MICROSCOPES

Fundamental & Clinical Pharmacology, 2023, Vol 37, Issue 5, p1006

0767-3981

Academic Journal

10.1111/fcp.12913