The HLA- A*2402/ Cw*0102 haplotype is associated with lamotrigine-induced maculopapular eruption in the Korean population.

Moon, Jangsup; Park, Han‐Ki; Chu, Kon; Sunwoo, Jun‐Sang; Byun, Jung‐Ick; Lim, Jung‐Ah; Kim, Tae‐Joon; Shin, Jung‐Won; Lee, Soon‐Tae; Jung, Keun‐Hwa; Jung, Ki‐Young; Jeon, Daejong; Kim, Dong Wook; Yu, Kyung‐Sang; Jang, In‐Jin; Kang, Hye‐Ryun; Park, Heung‐Woo; Lee, Sang Kun

The use of lamotrigine ( LTG) can be limited by the occurrence of cutaneous adverse drug reactions (c ADRs) that range from maculopapular eruption ( MPE) to the more severe Stevens-Johnson syndrome and toxic epidermal necrolysis. A few human leukocyte antigen ( HLA)-related genetic risk factors for carbamazepine-induced cADR have been identified. However, the HLA-related genetic risk factors associated with LTG-induced cADR are not yet well known. We performed HLA genotyping in 50 Korean patients with epilepsy, including 21 patients presenting LTG-induced MPE and 29 LTG-tolerant patients. A significant association between the HLA-A*2402 allele and LTG-induced MPE was identified, in comparison with the LTG-tolerant group (odds ratio [ OR] 4.09, p = 0.025) and the general Korean population ( OR 3.949, p = 0.005). The frequencies of the Cw*0102 or Cw*0702 alleles were significantly higher in the LTG- MPE group than in the Korean population, whereas the frequency of the A*3303 allele was lower. The coexistence of the A*2402 and Cw*0102 alleles was significantly associated with the LTG- MPE group when compared to the LTG-tolerant group ( OR 7.88, p = 0.007). In addition, the Cw*0701 allele was more frequent in the LTG-tolerant group than in the Korean population. These findings suggest the presence of HLA-related genetic risk factors for LTG-induced MPE in the Korean population.

HLA histocompatibility antigens; LAMOTRIGINE; CARBAMAZEPINE; STEVENS-Johnson Syndrome; DRUG side effects; KOREANS; DIAGNOSIS; THERAPEUTICS; DISEASES

Epilepsia (Series 4), 2015, Vol 56, Issue 10, pe161

0013-9580

Academic Journal

10.1111/epi.13087