Increased gallbladder emptying and reduced GLP‐1 response in pregnancy with and without gestational diabetes mellitus.

Gether, Ida M.; Andersen, Emilie S.; Foghsgaard, Signe; Ellegaard, Anne‐Marie; Kelstrup, Louise; Sonne, David P.; Brønden, Andreas; Gillum, Matthew P.; Holst, Jens J.; Hartmann, Bolette; Rehfeld, Jens F.; Vilsbøll, Tina; Knop, Filip K.

Aim: Gestational diabetes mellitus (GDM) has been associated with reduced postprandial glucagon‐like peptide 1 (GLP‐1) responses. As pregnancy induces changes in gallbladder motility and bile acids stimulate GLP‐1 secretion, we investigated postprandial gallbladder emptying and GLP‐1 responses in women with GDM. Methods: Women with and without GDM underwent two 240‐min mixed meal tests; one during third trimester of pregnancy and one 3–6 months postpartum. We evaluated ultrasonography‐assessed gallbladder emptying, plasma concentrations of glucometabolic hormones including GLP‐1, paracetamol absorption (proxy for gastric emptying) and circulating factors known to affect gallbladder dynamics. Results: Fifteen women with GDM and 15 pregnant women with normal glucose tolerance (NGT) (baseline median age 31 (interquartile range 29;33) versus 32 (28;33) years, body mass index (BMI) 27.2 (24.7;30.7) versus 28.4 (26.2;31.0) kg/m2, HbA1c 30 (29;32) versus 30 (28;31) mmol/mol) were included. No differences in postprandial gallbladder emptying or GLP‐1 responses were observed between women with and without GDM, neither during pregnancy nor postpartum. Pregnancy increased fasting gallbladder volumes by 69 (30;122)% and 103 (59;156)% and postprandial gallbladder emptying by 77 (28;236)% and 99 (37;190)% compared with postpartum in women with and without GDM, respectively. Postprandial GLP‐1 responses were reduced by 60 (3;82)% and 81 (11;90)% during pregnancy compared with postpartum in women with and without GDM, respectively. Conclusion: Pregnancy‐induced changes in gallbladder motility seem to play no or a limited role in previously reported GDM‐associated reduced postprandial GLP‐1 responses as gallbladder emptying was greater and postprandial GLP‐1 response was lower in pregnancy than postpartum regardless of GDM status.

FIRST trimester of pregnancy; GESTATIONAL diabetes; THIRD trimester of pregnancy; PREGNANT women; BODY mass index; GASTRIC emptying

Diabetes, Obesity & Metabolism, 2025, Vol 27, Issue 2, p697

1462-8902

Academic Journal

10.1111/dom.16064