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- Title
Increased cardiovascular risk in people with LADA in comparison to type 1 diabetes and type 2 diabetes: Findings from the DPV registry in Germany and Austria.
- Authors
Golomb, Rosa C.; Tittel, Sascha R.; Welters, Alena; Karges, Wolfram; Meyhöfer, Svenja; Hummel, Michael; Mader, Julia K.; Kämmer, Jörg‐C; Schloot, Nanette C.; Holl, Reinhard W.
- Abstract
Introduction: We aimed to characterise and compare individuals diagnosed with type 1 diabetes (T1D), latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D), in a real‐world setting. Methods: Anthropometric and clinical data from 36 959 people with diabetes diagnosed at age 30–70 years enrolled in the prospective diabetes patients follow‐up (DPV) registry from 1995 to 2022 were analysed cross‐sectionally at diagnosis and follow‐up (≥6 months after diagnosis). LADA was defined as clinical diagnosis of T2D, positivity of ≥1 islet autoantibody and an insulin‐free interval of ≥6 months upon diabetes diagnosis. Results: At diagnosis, age, body mass index, waist circumference, C‐peptide and HbA1c in people with LADA (n = 747) fell in between individuals with T1D (n = 940) and T2D (n = 35 272) (all p‐values < 0.01). At follow‐up, after adjusting for age, sex and diabetes duration, the prevalence of dyslipidemia and hypertension was the highest in people with LADA (90.6%, 77.7%) compared to people with T2D (81.8%, 60.4%) and T1D (75.7%, 39.7%) (p < 0.01). The prevalence of diabetic kidney disease (DKD) was higher in LADA (44.2%), than in T1D (19.9%) (p < 0.01). The prevalence of peripheral neuropathy was higher in individuals with LADA (55.1%) than in T2D (43.9%) and T1D (42.1%) (p < 0.05). Coverage of treatment for hypertension and dyslipidemia were 22.4% and 15.0% in T1D, 63.0% and 36.6% in LADA and 29.4% and 18.2% in T2D. Conclusion: People with LADA had a higher prevalence of cardiovascular risk factors (dyslipidemia, hypertension) and cardiovascular complications (DKD and peripheral neuropathy), suggesting that people with LADA are at need for improved recognition and care.
- Subjects
TYPE 2 diabetes; TYPE 1 diabetes; PEOPLE with diabetes; DIABETIC nephropathies; CARDIOVASCULAR diseases
- Publication
Diabetes, Obesity & Metabolism, 2025, Vol 27, Issue 2, p563
- ISSN
1462-8902
- Publication type
Academic Journal
- DOI
10.1111/dom.16048