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Title

Atypical clinical presentation of eosinophilic angiocentric fibrosis with cutaneous and upper respiratory tract involvement.

Authors

Liñán‐Barroso, Juan Manuel; Valérdiz‐Menéndez, Nicolás; García‐Morillo, José Salvador; Bernabeu‐Wittel, José

Abstract

This article discusses a case of eosinophilic angiocentric fibrosis (EAF) with atypical clinical presentation involving the skin and upper respiratory tract. EAF is a rare fibroinflammatory condition that primarily affects the orbit and upper respiratory tract. The patient in this case initially presented with a firm plaque on her thigh, which later became inflamed and coincided with upper respiratory tract infections. The diagnosis was confirmed through skin and nasal mucosa biopsies, which revealed characteristic histopathological findings, including eosinophils and IgG4 plasma cells. The patient's symptoms improved with treatment using methotrexate and prednisone. This case highlights the importance of recognizing the diverse and atypical manifestations of EAF for accurate diagnosis and management.

Subjects

SYMPTOMS; CHURG-Strauss syndrome; RESPIRATORY infections; NASAL mucosa; CELL anatomy; DISEASE remission; EOSINOPHILIC granuloma; EOSINOPHILIA

Publication

Journal of Cutaneous Pathology, 2024, Vol 51, Issue 11, p821

ISSN

0303-6987

Publication type

Academic Journal

DOI

10.1111/cup.14701

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