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[<sup>11</sup>C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients.
- Published in:
- Fluids & Barriers of the CNS, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12987-024-00588-8
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- Publication type:
- Article
Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling.
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- Alzheimer's Research & Therapy, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13195-021-00916-2
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- Publication type:
- Article
Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions.
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- Journal of Clinical Pharmacology, 2016, v. 56, p. S143, doi. 10.1002/jcph.722
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- Publication type:
- Article
[ 11 C]metoclopramide is a sensitive radiotracer to measure moderate decreases in P-glycoprotein function at the blood-brain barrier.
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- Journal of Cerebral Blood Flow & Metabolism, 2024, v. 44, n. 1, p. 142, doi. 10.1177/0271678X231202336
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- Publication type:
- Article
Comparative vulnerability of PET radioligands to partial inhibition of P-glycoprotein at the blood-brain barrier: A criterion of choice?
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- Journal of Cerebral Blood Flow & Metabolism, 2022, v. 42, n. 1, p. 175, doi. 10.1177/0271678X211045444
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- Publication type:
- Article
Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [ 11 C]erlotinib.
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- Journal of Cerebral Blood Flow & Metabolism, 2021, v. 41, n. 7, p. 1634, doi. 10.1177/0271678X20965500
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- Publication type:
- Article
Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography.
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- Journal of Cerebral Blood Flow & Metabolism, 2020, v. 40, n. 5, p. 954, doi. 10.1177/0271678X19854541
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- Publication type:
- Article
Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET.
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- Journal of Cerebral Blood Flow & Metabolism, 2020, v. 40, n. 1, p. 150, doi. 10.1177/0271678X18806640
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- Publication type:
- Article
Approaching complete inhibition of P-glycoprotein at the human blood-brain barrier: an (R)-[<sup>11</sup>C]verapamil PET study.
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- Journal of Cerebral Blood Flow & Metabolism, 2015, v. 35, n. 5, p. 743, doi. 10.1038/jcbfm.2015.19
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- Publication type:
- Article
A novel PET protocol for visualization of breast cancer resistance protein function at the blood-brain barrier.
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- Journal of Cerebral Blood Flow & Metabolism, 2012, v. 32, n. 11, p. 2002, doi. 10.1038/jcbfm.2012.112
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- Publication type:
- Article
Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood–brain barrier.
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- Journal of Cerebral Blood Flow & Metabolism, 2010, v. 30, n. 3, p. 510, doi. 10.1038/jcbfm.2009.265
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- Publication type:
- Article
Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using ( R)-[<sup>11</sup>C]verapamil PET.
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- European Journal of Nuclear Medicine & Molecular Imaging, 2010, v. 37, n. 5, p. 942, doi. 10.1007/s00259-009-1332-5
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- Publication type:
- Article
Peripheral metabolism of ( R)-[<sup>11</sup>C]verapamil in epilepsy patients.
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- European Journal of Nuclear Medicine & Molecular Imaging, 2008, v. 35, n. 1, p. 116, doi. 10.1007/s00259-007-0556-5
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- Publication type:
- Article
In vitro and in vivo evaluation of [<sup>18</sup>F]ciprofloxacin for the imaging of bacterial infections with PET.
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- European Journal of Nuclear Medicine & Molecular Imaging, 2005, v. 32, n. 2, p. 143, doi. 10.1007/s00259-004-1646-2
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- Publication type:
- Article
PET and SPET tracers for mapping the cardiac nervous system.
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- European Journal of Nuclear Medicine & Molecular Imaging, 2002, v. 29, n. 3, p. 416, doi. 10.1007/s002590100640
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- Publication type:
- Article
Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus -- Lessons from Three Unsuccessful Approaches.
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- European Journal of Microbiology & Immunology, 2018, v. 8, n. 3, p. 78, doi. 10.1556/1886.2018.00008
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- Publication type:
- Article
Radiosynthesis and assessment of ocular pharmacokinetics of (124)I-labeled chitosan in rabbits using small-animal PET.
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- 2011
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- Publication type:
- journal article
Limitations of small animal PET imaging with [18F]FDDNP and FDG for quantitative studies in a transgenic mouse model of Alzheimer's disease.
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- 2009
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- Publication type:
- journal article
Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography.
- Published in:
- AAPS Journal, 2019, v. 21, n. 4, p. 1, doi. 10.1208/s12248-019-0323-0
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- Publication type:
- Article
Microdialysis versus other techniques for the clinical assessment of in vivo tissue drug distribution.
- Published in:
- AAPS Journal, 2006, v. 8, n. 2, p. E263, doi. 10.1007/BF02854896
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- Publication type:
- Article
St. John's wort extract with a high hyperforin content does not induce P‐glycoprotein activity at the human blood–brain barrier.
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- CTS: Clinical & Translational Science, 2024, v. 17, n. 5, p. 1, doi. 10.1111/cts.13804
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- Publication type:
- Article
Strategic, feasibility, economic, and cultural aspects of phase 0 approaches: Is it time to change the drug development process in order to increase productivity?
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- CTS: Clinical & Translational Science, 2022, v. 15, n. 6, p. 1355, doi. 10.1111/cts.13269
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- Publication type:
- Article
Expression of endogenous mouse APP modulates β-amyloid deposition in hAPPtransgenic mice.
- Published in:
- Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0448-2
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- Publication type:
- Article
Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2013, v. 56, n. 3/4, p. 68, doi. 10.1002/jlcr.2993
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- Publication type:
- Article
Synthesis of fluorine-18-labelled 5- and 6-fluoro-2-pyridinamine.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2006, v. 49, n. 4, p. 345, doi. 10.1002/jlcr.1049
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- Publication type:
- Article
Synthesis of 1,1′ [<sup>11</sup>C]-methylene-di-(2-naphthol) ([<sup>11</sup>C]ST1859) for PET studies in humans.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2005, v. 48, n. 8, p. 577, doi. 10.1002/jlcr.951
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- Publication type:
- Article
A general method for the fluorine-18 labelling of fluoroquinolone antibiotics.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2003, v. 46, n. 8, p. 715
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- Publication type:
- Article
Preparation of 4-[<sup>11</sup>C]methylmetaraminol, a potential PET tracer for assessment of myocardial sympathetic innervation.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2003, v. 46, n. 1, p. 55, doi. 10.1002/jlcr.642
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- Publication type:
- Article
Precursor synthesis and radiolabelling of [<sup>11</sup>C]ADAM: a potential radioligand for the serotonin transporter exploration by PET.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2001, v. 44, n. 2, p. 113, doi. 10.1002/jlcr.436
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- Publication type:
- Article
Preparation of [<sup>18</sup>F]β-CFT-FP and [<sup>11</sup>C]β-CFT-FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET).
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2000, v. 43, n. 12, p. 1235, doi. 10.1002/1099-1344(20001030)43:12<1235::AID-JLCR411>3.0.CO;2-9
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- Publication type:
- Article
Radiochemical labelling of the dopamine D<sub>3</sub> receptor ligand RGH-1756.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2000, v. 43, n. 11, p. 1069, doi. 10.1002/1099-1344(20001015)43:11<1069::AID-JLCR390>3.0.CO;2-N
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- Publication type:
- Article
Improved specific radioactivity of the PET radioligand [<sup>11</sup>C]FLB 457 by use of the GE medical systems PETtrace MeI microlab.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2000, v. 43, n. 4, p. 331, doi. 10.1002/(SICI)1099-1344(20000330)43:4<331::AID-JLCR320>3.0.CO;2-H
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- Publication type:
- Article
Precursor synthesis and radiolabelling of the dopamine D<sub>2</sub> receptor ligand [<sup>11</sup>C]raclopride from [<sup>11</sup>C]methyl triflate.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 1999, v. 42, n. 12, p. 1183, doi. 10.1002/(SICI)1099-1344(199912)42:12<1183::AID-JLCR274>3.0.CO;2-Z
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- Publication type:
- Article
Preparation of 4- and 6-[<sup>76</sup>Br] bromometaraminol, two potential radiotracers for the study of the myocardial norepinephrine neuronal reuptake system with PET.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 1997, v. 39, n. 10, p. 803, doi. 10.1002/(SICI)1099-1344(199710)39:10<803::AID-JLCR27>3.0.CO;2-R
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- Publication type:
- Article
Age dependency of cerebral P-gp function measured with ( R)-[<sup>11</sup>C]verapamil and PET.
- Published in:
- European Journal of Clinical Pharmacology, 2009, v. 65, n. 9, p. 941, doi. 10.1007/s00228-009-0709-5
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- Publication type:
- Article
Advancing 6-bromo-7-[<sup>11</sup>C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates.
- Published in:
- EJNMMI Radiopharmacy & Chemistry, 2024, v. 9, n. 1, p. 1, doi. 10.1186/s41181-024-00265-z
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- Publication type:
- Article
Proof-of-Concept Study of Drug Brain Permeability Between in Vivo Human Brain and an in Vitro iPSCs-Human Blood-Brain Barrier Model.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-52213-6
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- Publication type:
- Article
ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure.
- Published in:
- Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.698966
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- Publication type:
- Article
In vivo characterization of [18F]AVT-011 as a radiotracer for PET imaging of multidrug resistance.
- Published in:
- European Journal of Nuclear Medicine & Molecular Imaging, 2020, v. 47, n. 8, p. 2026, doi. 10.1007/s00259-019-04589-w
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- Publication type:
- Article
[F]FE@SUPPY: a suitable PET tracer for the adenosine A3 receptor? An in vivo study in rodents.
- Published in:
- European Journal of Nuclear Medicine & Molecular Imaging, 2015, v. 42, n. 5, p. 741, doi. 10.1007/s00259-014-2976-3
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- Publication type:
- Article
A comparative small-animal PET evaluation of [C]tariquidar, [C]elacridar and ( R)-[C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.
- Published in:
- European Journal of Nuclear Medicine & Molecular Imaging, 2012, v. 39, n. 1, p. 149, doi. 10.1007/s00259-011-1941-7
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- Publication type:
- Article
Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [11C]Metoclopramide in Mice.
- Published in:
- Pharmaceutical Research, 2021, v. 38, n. 1, p. 127, doi. 10.1007/s11095-021-03002-2
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- Publication type:
- Article
Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of ( R)-[<sup>11</sup>C]verapamil in elderly vs. young subjects.
- Published in:
- British Journal of Clinical Pharmacology, 2017, v. 83, n. 9, p. 1991, doi. 10.1111/bcp.13301
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- Publication type:
- Article
A Novel Positron Emission Tomography Imaging Protocol Identifies Seizure-Induced Regional Overactivity of P-Glycoprotein at the Blood-Brain Barrier.
- Published in:
- Journal of Neuroscience, 2011, v. 31, n. 24, p. 8803, doi. 10.1523/JNEUROSCI.6616-10.2011
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- Publication type:
- Article
Blood-brain barrier p-glycoprotein function in Alzheimer's disease
- Published in:
- 2011
- By:
- Publication type:
- Abstract
Inhibition of breast cancer resistance protein at the murine blood-brain barrier by Ko143 studied with [<sup>11</sup>C]tariquidar and PET.
- Published in:
- 2011
- By:
- Publication type:
- Abstract
[<sup>11</sup>C]Elacridar as a novel P-glycoprotein PET tracer, assessment of whole-body distribution and radiation dosimetry in humans.
- Published in:
- 2011
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- Publication type:
- Abstract
BEZ235 impairs gastric cancer growth by inhibition of PI3K/mTOR in vitro and in vivo.
- Published in:
- 2010
- By:
- Publication type:
- Abstract
Dose-response assessment of tariquidar for inhibition of P-glycoprotein at the human blood-brain barrier using (R)-[<sup>11</sup>C]verapamil PET.
- Published in:
- 2010
- By:
- Publication type:
- Abstract
Small-animal PET evaluation of [<sup>11</sup>C]MC113 as a PET tracer for P-glycoprotein.
- Published in:
- 2010
- By:
- Publication type:
- Abstract