OpenURL Connection Search

Select item for more details and to access through your institution.

Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds.
Published in:
Scientific Data, 2022, v. 9, n. 1, p. 1, doi. 10.1038/s41597-022-01825-1
By:
- Verheijen, Marcha;
- Sarkans, Ugis;
- Wolski, Witold;
- Jennen, Danyel;
- Caiment, Florian;
- Kleinjans, Jos;
- HeCaToS Consortium;
- Agarkova, Irina;
- Atkinson, Francis L.;
- Bachmann, Ivo;
- Baier, Vanessa;
- Barel, Gal;
- Bauer, Chris;
- van den Beucken, Twan;
- Boerno, Stefan;
- Bosc, Nicolas;
- Carey, Conn;
- Castell, José V.;
- Clayton, Olivia;
- Cordes, Henrik
Publication type:
Article
Quantitative Prediction of Steatosis in Patients with Non-Alcoholic Fatty Liver by Means of Hepatic MicroRNAs Present in Serum and Correlating with Hepatic Fat.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 16, p. 9298, doi. 10.3390/ijms23169298
By:
- Quintás, Guillermo;
- Caiment, Florian;
- Rienda, Iván;
- Pérez-Rojas, Judith;
- Pareja, Eugenia;
- Castell, José V.;
- Jover, Ramiro
Publication type:
Article
SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 10, p. 3648, doi. 10.3390/ijms21103648
By:
- Moroni, Lorenzo;
- Barbaro, Fulvio;
- Caiment, Florian;
- Coleman, Orla;
- Costagliola, Sabine;
- Di Conza, Giusy;
- Elviri, Lisa;
- Giselbrecht, Stefan;
- Krause, Christian;
- Mota, Carlos;
- Nazzari, Marta;
- Pennington, Stephen R.;
- Ringwald, Annette;
- Sandri, Monica;
- Thomas, Simon;
- Waddington, James;
- Toni, Roberto
Publication type:
Article
Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity.
Published in:
Archives of Toxicology, 2023, v. 97, n. 8, p. 2291, doi. 10.1007/s00204-023-03522-3
By:
- Gant, Timothy W.;
- Auerbach, Scott S.;
- Von Bergen, Martin;
- Bouhifd, Mounir;
- Botham, Philip A.;
- Caiment, Florian;
- Currie, Richard A.;
- Harrill, Joshua;
- Johnson, Kamin;
- Li, Dongying;
- Rouquie, David;
- van Ravenzwaay, Ben;
- Sistare, Frank;
- Tralau, Tewes;
- Viant, Mark R.;
- van de Laan, Jan Willem;
- Yauk, Carole
Publication type:
Article
High-throughput data integration of RNA-miRNA-circRNA reveals novel insights into mechanisms of benzo[a]pyrene-induced carcinogenicity.
Published in:
Nucleic Acids Research, 2015, v. 43, n. 5, p. 2525, doi. 10.1093/nar/gkv115
By:
- Caiment, Florian;
- Gaj, Stan;
- Claessen, Sandra;
- Kleinjans, Jos
Publication type:
Article
The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance.
Published in:
Nature Biotechnology, 2014, v. 32, n. 9, p. 926, doi. 10.1038/nbt.3001
By:
- Wang, Charles;
- Gong, Binsheng;
- Bushel, Pierre R;
- Thierry-Mieg, Jean;
- Thierry-Mieg, Danielle;
- Xu, Joshua;
- Fang, Hong;
- Hong, Huixiao;
- Shen, Jie;
- Su, Zhenqiang;
- Meehan, Joe;
- Li, Xiaojin;
- Yang, Lu;
- Li, Haiqing;
- Łabaj, Paweł P;
- Kreil, David P;
- Megherbi, Dalila;
- Gaj, Stan;
- Caiment, Florian;
- van Delft, Joost
Publication type:
Article
A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep.
Published in:
Nature Genetics, 2006, v. 38, n. 7, p. 813, doi. 10.1038/ng1810
By:
- Clop, Alex;
- Marcq, Fabienne;
- Takeda, Haruko;
- Pirottin, Dimitri;
- Tordoir, Xavier;
- Bibé, Bernard;
- Bouix, Jacques;
- Caiment, Florian;
- Elsen, Jean-Michel;
- Eychenne, Francis;
- Larzul, Catherine;
- Laville, Elisabeth;
- Meish, Françoise;
- Milenkovic, Dragan;
- Tobin, James;
- Charlier, Carole;
- Georges, Michel
Publication type:
Article
IsoTools: a flexible workflow for long-read transcriptome sequencing analysis.
Published in:
Bioinformatics, 2023, v. 39, n. 6, p. 1, doi. 10.1093/bioinformatics/btad364
By:
- Lienhard, Matthias;
- van den Beucken, Twan;
- Timmermann, Bernd;
- Hochradel, Myriam;
- Börno, Stefan;
- Caiment, Florian;
- Vingron, Martin;
- Herwig, Ralf
Publication type:
Article
FuSe: a tool to move RNA-Seq analyses from chromosomal/gene loci to functional grouping of mRNA transcripts.
Published in:
Bioinformatics, 2021, v. 37, n. 3, p. 375, doi. 10.1093/bioinformatics/btaa735
By:
- Gupta, Rajinder;
- Schrooders, Yannick;
- Verheijen, Marcha;
- Roth, Adrian;
- Kleinjans, Jos;
- Caiment, Florian
Publication type:
Article
The Rat microRNA body atlas; Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dog.
Published in:
BMC Genomics, 2016, v. 17, p. 1, doi. 10.1186/s12864-016-2956-z
By:
- Smith, Aaron;
- Calley, John;
- Sachin Mathur;
- Hui-Rong Qian;
- Han Wu;
- Farmen, Mark;
- Caiment, Florian;
- Bushel, Pierre R.;
- Jianying Li;
- Fisher, Craig;
- Kirby, Patrick;
- Koenig, Erik;
- Hall, David G.;
- Watson, David E
Publication type:
Article
Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq.
Published in:
Frontiers in Endocrinology, 2023, p. 1, doi. 10.3389/fendo.2023.1200211
By:
- Nazzari, Marta;
- Romitti, Mirian;
- Hauser, Duncan;
- Carvalho, Daniel J.;
- Giselbrecht, Stefan;
- Moroni, Lorenzo;
- Costagliola, Sabine;
- Caiment, Florian
Publication type:
Article
Network integration and modelling of dynamic drug responses at multi-omics levels.
Published in:
Communications Biology, 2020, v. 3, n. 1, p. N.PAG, doi. 10.1038/s42003-020-01302-8
By:
- Selevsek, Nathalie;
- Caiment, Florian;
- Nudischer, Ramona;
- Gmuender, Hans;
- Agarkova, Irina;
- Atkinson, Francis L.;
- Bachmann, Ivo;
- Baier, Vanessa;
- Barel, Gal;
- Bauer, Chris;
- Boerno, Stefan;
- Bosc, Nicolas;
- Clayton, Olivia;
- Cordes, Henrik;
- Deeb, Sally;
- Gotta, Stefano;
- Guye, Patrick;
- Hersey, Anne;
- Hunter, Fiona M. I.;
- Kunz, Laura
Publication type:
Article
Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment.
Published in:
Acta Neuropathologica Communications, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40478-023-01627-5
By:
- Manukjan, Narek;
- Majcher, Daria;
- Leenders, Peter;
- Caiment, Florian;
- van Herwijnen, Marcel;
- Smeets, Hubert J.;
- Suidgeest, Ernst;
- van der Weerd, Louise;
- Vanmierlo, Tim;
- Jansen, Jacobus F. A.;
- Backes, Walter H.;
- van Oostenbrugge, Robert J.;
- Staals, Julie;
- Fulton, Daniel;
- Ahmed, Zubair;
- Blankesteijn, W. Matthijs;
- Foulquier, Sébastien
Publication type:
Article
Hepatic Steatosis Contributes to the Development of Muscle Atrophy via Inter-Organ Crosstalk.
Published in:
Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.733625
By:
- Pasmans, Kenneth;
- Adriaens, Michiel E.;
- Olinga, Peter;
- Langen, Ramon;
- Rensen, Sander S.;
- Schaap, Frank G.;
- Olde Damink, Steven W. M.;
- Caiment, Florian;
- van Loon, Luc J. C.;
- Blaak, Ellen E.;
- Meex, Ruth C. R.
Publication type:
Article
The MicroRNA-based Liquid Biopsy Improves Early Assessment of Lethal Acetaminophen Poisoning: A Case Report.
Published in:
American Journal of Case Reports, 2020, v. 21, p. 1, doi. 10.12659/AJCR.919289
By:
- Krauskopf, Julian;
- Gosink, Mark M.;
- Schomaker, Shelli;
- Caiment, Florian;
- Warner, Roscoe;
- Johnson, Kent;
- Kleinjans, Jos;
- Aubrecht, Jiri
Publication type:
Article
Identifying novel transcript biomarkers for hepatocellular carcinoma (HCC) using RNA-Seq datasets and machine learning.
Published in:
2021
By:
- Gupta, Rajinder;
- Kleinjans, Jos;
- Caiment, Florian
Publication type:
journal article
CODA: a combo-Seq data analysis workflow.
Published in:
Briefings in Bioinformatics, 2023, v. 24, n. 1, p. 1, doi. 10.1093/bib/bbac582
By:
- Nazzari, Marta;
- Hauser, Duncan;
- Herwijnen, Marcel van;
- Romitti, Mírian;
- Carvalho, Daniel J;
- Kip, Anna M;
- Caiment, Florian
Publication type:
Article
Assessing compound carcinogenicity in vitro using connectivity mapping.
Published in:
Carcinogenesis, 2014, v. 35, n. 1, p. 201, doi. 10.1093/carcin/bgt278
By:
- Caiment, Florian;
- Tsamou, Maria;
- Jennen, Danyel;
- Kleinjans, Jos
Publication type:
Article
A Model‐Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs.
Published in:
Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 5, p. 1293, doi. 10.1002/cpt.2406
By:
- Baier, Vanessa;
- Clayton, Olivia;
- Nudischer, Ramona;
- Cordes, Henrik;
- Schneider, Annika R. P.;
- Thiel, Christoph;
- Wittenberger, Timo;
- Moritz, Wolfgang;
- Blank, Lars M.;
- Neumann, Ulf P.;
- Trautwein, Christian;
- Kelm, Jens;
- Schrooders, Yannick;
- Caiment, Florian;
- Gmuender, Hans;
- Roth, Adrian;
- Castell, José V.;
- Kleinjans, Jos;
- Kuepfer, Lars
Publication type:
Article
MicroRNA-4732-3p Is Dysregulated in Breast Cancer Patients with Cardiotoxicity, and Its Therapeutic Delivery Protects the Heart from Doxorubicin-Induced Oxidative Stress in Rats.
Published in:
Antioxidants, 2022, v. 11, n. 10, p. N.PAG, doi. 10.3390/antiox11101955
By:
- Sánchez-Sánchez, Rafael;
- Reinal, Ignacio;
- Peiró-Molina, Esteban;
- Buigues, Marc;
- Tejedor, Sandra;
- Hernándiz, Amparo;
- Selva, Marta;
- Hervás, David;
- Cañada, Antonio J.;
- Dorronsoro, Akaitz;
- Santaballa, Ana;
- Salvador, Carmen;
- Caiment, Florian;
- Kleinjans, Jos;
- Martínez-Dolz, Luis;
- Moscoso, Isabel;
- Lage, Ricardo;
- González-Juanatey, José R.;
- Panadero, Joaquín;
- Aparicio-Puerta, Ernesto
Publication type:
Article
Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-89550-4
By:
- Chandrasekaran, Vidya;
- Carta, Giada;
- da Costa Pereira, Daniel;
- Gupta, Rajinder;
- Murphy, Cormac;
- Feifel, Elisabeth;
- Kern, Georg;
- Lechner, Judith;
- Cavallo, Anna Lina;
- Gupta, Shailesh;
- Caiment, Florian;
- Kleinjans, Jos C. S.;
- Gstraunthaler, Gerhard;
- Jennings, Paul;
- Wilmes, Anja
Publication type:
Article
Acrylamide alters CREB and retinoic acid signalling pathways during differentiation of the human neuroblastoma SH-SY5Y cell line.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-73698-6
By:
- Attoff, Kristina;
- Johansson, Ylva;
- Cediel-Ulloa, Andrea;
- Lundqvist, Jessica;
- Gupta, Rajinder;
- Caiment, Florian;
- Gliga, Anda;
- Forsby, Anna
Publication type:
Article
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.
Published in:
2018
By:
- Kuepfer, Lars;
- Clayton, Olivia;
- Thiel, Christoph;
- Cordes, Henrik;
- Nudischer, Ramona;
- Blank, Lars M.;
- Baier, Vanessa;
- Heymans, Stephane;
- Caiment, Florian;
- Roth, Adrian;
- Fluri, David A.;
- Kelm, Jens M.;
- Castell, José;
- Selevsek, Nathalie;
- Schlapbach, Ralph;
- Keun, Hector;
- Hynes, James;
- Sarkans, Ugis;
- Gmuender, Hans;
- Herwig, Ralf
Publication type:
Letter
Thyroid‐on‐a‐Chip: An Organoid Platform for In Vitro Assessment of Endocrine Disruption (Adv. Healthcare Mater. 8/2023).
Published in:
Advanced Healthcare Materials, 2023, v. 12, n. 8, p. 1, doi. 10.1002/adhm.202370038
By:
- Carvalho, Daniel J.;
- Kip, Anna M.;
- Romitti, Mírian;
- Nazzari, Marta;
- Tegel, Andreas;
- Stich, Matthias;
- Krause, Christian;
- Caiment, Florian;
- Costagliola, Sabine;
- Moroni, Lorenzo;
- Giselbrecht, Stefan
Publication type:
Article
Thyroid‐on‐a‐Chip: An Organoid Platform for In Vitro Assessment of Endocrine Disruption.
Published in:
Advanced Healthcare Materials, 2023, v. 12, n. 8, p. 1, doi. 10.1002/adhm.202201555
By:
- Carvalho, Daniel J.;
- Kip, Anna M.;
- Romitti, Mírian;
- Nazzari, Marta;
- Tegel, Andreas;
- Stich, Matthias;
- Krause, Christian;
- Caiment, Florian;
- Costagliola, Sabine;
- Moroni, Lorenzo;
- Giselbrecht, Stefan
Publication type:
Article
Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease.
Published in:
CTS: Clinical & Translational Science, 2019, v. 12, n. 6, p. 609, doi. 10.1111/cts.12663
By:
- Bohler, Sacha;
- Liu, Xiaosong;
- Krauskopf, Julian;
- Caiment, Florian;
- Aubrecht, Jiri;
- Nicolaes, Gerry A. F.;
- Kleinjans, Jos C. S.;
- Briedé, Jacco J.
Publication type:
Article
RATEmiRs: the rat atlas of tissue-specific and enriched miRNAs database.
Published in:
BMC Genomics, 2018, v. 19, n. 1, p. 1, doi. 10.1186/s12864-018-5220-x
By:
- Bushel, Pierre R.;
- Caiment, Florian;
- Wu, Han;
- O'Lone, Raegan;
- Day, Frank;
- Calley, John;
- Smith, Aaron;
- Li, Jianying
Publication type:
Article
A novel orthotopic mouse model replicates human lung cancer cachexia.
Published in:
Journal of Cachexia, Sarcopenia & Muscle, 2023, v. 14, n. 3, p. 1410, doi. 10.1002/jcsm.13222
By:
- van de Worp, Wouter R.P.H.;
- Theys, Jan;
- González, Alba Sanz;
- van der Heyden, Brent;
- Verhaegen, Frank;
- Hauser, Duncan;
- Caiment, Florian;
- Smeets, Hubertus J.M.;
- Schols, Annemie M.W.J.;
- van Helvoort, Ardy;
- Langen, Ramon C.J.
Publication type:
Article
Wnt7a Decreases Brain Endothelial Barrier Function Via β-Catenin Activation.
Published in:
Molecular Neurobiology, 2024, v. 61, n. 7, p. 4854, doi. 10.1007/s12035-023-03872-0
By:
- Manukjan, Narek;
- Chau, Steven;
- Caiment, Florian;
- van Herwijnen, Marcel;
- Smeets, Hubert J.;
- Fulton, Daniel;
- Ahmed, Zubair;
- Blankesteijn, W. Matthijs;
- Foulquier, Sébastien
Publication type:
Article
Application of High-Throughput Sequencing to Circulating microRNAs Reveals Novel Biomarkers for Drug-Induced Liver Injury.
Published in:
Toxicological Sciences, 2015, v. 143, n. 2, p. 268, doi. 10.1093/toxsci/kfu232
By:
- Krauskopf, Julian;
- Caiment, Florian;
- Claessen, Sandra M.;
- Johnson, Kent J.;
- Warner, Roscoe L.;
- Schomaker, Shelli J.;
- Burt, Deborah A.;
- Aubrecht, Jiri;
- Kleinjans, Jos C.
Publication type:
Article
diXa: a data infrastructure for chemical safety assessment.
Published in:
2015
By:
- Hendrickx, Diana M.;
- Aerts, Hugo J. W. L.;
- Caiment, Florian;
- Clark, Dominic;
- Ebbels, Timothy M. D.;
- Evelo, Chris T.;
- Gmuender, Hans;
- Hebels, Dennie G. A. J.;
- Herwig, Ralf;
- Hescheler, Jürgen;
- Jennen, Danyel G. J.;
- Jetten, Marlon J. A.;
- Kanterakis, Stathis;
- Keun, Hector C.;
- Matser, Vera;
- Overington, John P.;
- Pilicheva, Ekaterina;
- Sarkans, Ugis;
- Segura-Lepe, Marcelo P.;
- Sotiriadou, Isaia
Publication type:
Product Review
Author Correction: Analysis of cell-specific transcriptional responses in human colon tissue using CIBERSORTx.
Published in:
2024
By:
- He, Yueqin;
- DeBenedictis, Julia Nicole;
- Caiment, Florian;
- van Breda, Simone G. J.;
- de Kok, Theo M. C. M.
Publication type:
Correction Notice
Analysis of cell-specific transcriptional responses in human colon tissue using CIBERSORTx.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-45582-6
By:
- He, Yueqin;
- De Benedictis, Julia Nicole;
- Caiment, Florian;
- van Breda, Simone G. J.;
- de Kok, Theo M. C. M.
Publication type:
Article
Analysis of cell-specific transcriptional responses in human colon tissue using CIBERSORTx.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-45582-6
By:
- He, Yueqin;
- De Benedictis, Julia Nicole;
- Caiment, Florian;
- van Breda, Simone G. J.;
- de Kok, Theo M. C. M.
Publication type:
Article
Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human.
Published in:
PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0177928
By:
- Krauskopf, Julian;
- de Kok, Theo M.;
- Schomaker, Shelli J.;
- Gosink, Mark;
- Burt, Deborah A.;
- Chandler, Patricia;
- Warner, Roscoe L.;
- Johnson, Kent J.;
- Caiment, Florian;
- Kleinjans, Jos C.;
- Aubrecht, Jiri
Publication type:
Article
High-throughput sequencing reveals novel microRNAs in the Bovine Leukemia Virus (BLV)-induced ovine model of leukemia.
Published in:
2011
By:
- Rosewick, Nicolas;
- dehouck, Céline;
- Cleuter, Yvette;
- Caiment, Florian;
- Georges, Michel;
- Martiat, Philippe;
- Burny, Arsène;
- Van den Broeke, Anne
Publication type:
Abstract

Found: 36