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- Title
Higher mortality in metabolically obese normal-weight people than in metabolically healthy obese subjects in elderly Koreans.
- Authors
Choi, Kyung Mook; Cho, Hyun Joo; Choi, Hae Yoon; Yang, Sae Jeong; Yoo, Hye Jin; Seo, Ji A.; Kim, Sin Gon; Baik, Sei Hyun; Choi, Dong Seop; Kim, Nan Hee
- Abstract
Objective The purpose of this study was to investigate the impact of body mass index ( BMI) and the presence of metabolic syndrome (MetS) on all-cause and cardiovascular mortality in elderly Korean men and women, and especially to compare metabolically obese normal-weight ( MONW) and metabolically healthy obese ( MHO) subjects. Patients and methods A total of 2317 elderly people (over 60 years of age) were studied using follow-up data from the South-West Seoul ( SWS) Study, a prospective cohort study. Mortality from all causes and cardiovascular disease ( CVD) were evaluated according to the combination of the presence or absence of MetS and Asian-specific body mass index ( BMI) criteria ( BMI <23 kg/m2; normal weight, BMI 23-24·9 kg/m2; overweight, BMI ≥25 kg/m2; obesity). Results During a median follow-up of 10·3 years, 393 subjects died, including 126 from CVD. Among subjects with MetS, all-cause and CVD mortality were significantly higher in normal-weight subjects than overweight or obese individuals in Cox proportional-hazard models adjusted for confounding factors. Furthermore, among six groups with various MetS/ BMI combinations, MONW individuals had the highest risk, whereas overweight subjects without MetS had the lowest risk of death from all causes and CVD [ HR = 2·2 (95% CI = 1·4-3·4), HR = 3·0 (95% CI = 1·4-6·6) respectively]. Interestingly, all-cause mortality was significantly higher in MONW than MHO individuals. Conclusions In contrast to MHO subjects, elderly individuals with the MONW phenotype exhibited greater all-cause mortality during 10 years of follow-up.
- Subjects
MORTALITY; OVERWEIGHT persons; METABOLIC syndrome; DISEASES in older people; KOREANS; COHORT analysis
- Publication
Clinical Endocrinology, 2013, Vol 79, Issue 3, p364
- ISSN
0300-0664
- Publication type
Academic Journal
- DOI
10.1111/cen.12154