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- Title
Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress.
- Authors
Pfeiffer, Annika; Jaeckel, Martin; Lewerenz, Jan; Noack, Rebecca; Pouya, Alireza; Schacht, Teresa; Hoffmann, Christina; Winter, Jennifer; Schweiger, Susann; Schäfer, Michael K E; Methner, Axel
- Abstract
The hippocampal cell line HT22 is an excellent model for studying the consequences of endogenous oxidative stress. Extracellular glutamate depletes cellular glutathione by blocking the glutamate/cystine antiporter system xc-. Glutathione depletion induces a well-defined programme of cell death characterized by an increase in reactive oxygen species and mitochondrial dysfunction.
- Publication
British journal of pharmacology, 2014, Vol 171, Issue 8, p2147
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/bph.12549