A 64‐Year‐Old Patient With a Mesiotemporal Mass and Symptomatic Epilepsy.

Kuehn, Julia C.; Scheuerle, Angelika; Bauer, Jan; Becker, Albert J.; Wirtz, Rainer; Lewerenz, Jan

A 64-year-old Caucasian male presented with a three-month-history of episodes with visual disturbances and tingling sensations of the left side of his body to a department of neurology. However, a diffuse swelling hippocampus with contrast enhancement upon MRI may indicate a higher grade glioma or inflammatory changes in the context of a limbic encephalitis. In addition, neuron-specific complement end-complex deposition, as found in our case and reported previously [2], probably contributes to neuronal death in LGI1-E. This mechanism seems to be absent in anti-NMDA receptor encephalitis, the most common form of autoimmune encephalitis [2].

EPILEPSY; GRANULE cells; IMMUNOCOMPETENT cells; ANTI-NMDA receptor encephalitis; PATHOLOGY; METHYL aspartate receptors; AUTOANTIBODIES; COMPLEMENT receptors

Brain Pathology, 2020, Vol 30, Issue 2, p413

1015-6305

Academic Journal

10.1111/bpa.12818