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Dimeric Amyloid Β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease.
Published in:
Journal of Neuroscience, 2004, v. 24, n. 15, p. 3801, doi. 10.1523/JNEUROSCI.5543-03.2004
By:
- Kawarabayashi, Takeshi;
- Shoji, Mikio;
- Younkin, Linda H.;
- Lin Wen-Lang;
- Dickson, Dennis W.;
- Murakami, Tetsuro;
- Matsubara, Etsuro;
- Abe, Koji;
- Ashe, Karen Hsiao;
- Younkin, Steven G.
Publication type:
Article
Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 417, doi. 10.1002/alz.12198
By:
- Hou, Xu;
- Watzlawik, Jens O.;
- Cook, Casey;
- Liu, Chia‐Chen;
- Kang, Silvia S.;
- Lin, Wen‐Lang;
- DeTure, Michael;
- Heckman, Michael G.;
- Diehl, Nancy N.;
- Al‐Shaikh, Fadi S. Hanna;
- Walton, Ronald L.;
- Ross, Owen A.;
- Melrose, Heather L.;
- Ertekin‐Taner, Nilüfer;
- Bu, Guojun;
- Petrucelli, Leonard;
- Fryer, John D.;
- Murray, Melissa E.;
- Dickson, Dennis W.;
- Fiesel, Fabienne C.
Publication type:
Article
DISTINCT ULTRASTRUCTURAL CHARACTERISTICS OF CAPILLARY BASAL LAMINA IN HUMAN AND MOUSE BRAINS: RELEVANCE TO MURINE MODELS OF NEUROVASCULAR DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1391, doi. 10.1016/j.jalz.2017.06.2147
By:
- Lin, Wen-Lang;
- Dickson, Dennis W.
Publication type:
Article
Wild-type human TDP-43 induces mitochondrial abnormalities and axonal degeneration in transgenic mice
Published in:
2010
By:
- Xu, Yafei;
- Gendron, Tania;
- Zhang, Yongjie;
- Lin, Wen-Lang;
- D'Alton, Simon;
- Sheng, Hong;
- Crook, Richard;
- Casey, Monica Castanedes;
- Tong, Jimei;
- Knight, Joshua;
- Yu, Xin;
- Rademakers, Rosa;
- Boylan, Kevin;
- Hutton, Mike;
- McGowan, Eileen;
- Dickson, Dennis W.;
- Petrucelli, Leonard;
- Lewis, Jada
Publication type:
Abstract
Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggests a role for progranulin in successful aging
Published in:
2010
By:
- Ahmed, Zeshan;
- Sheng, Hong;
- Xu, Ya-fei;
- Lin, Wen-Lang;
- Innes, Amy E.;
- Yu, Xin;
- Hou, Harold;
- Chiba, Shuichi;
- Yamanouchi, Keitaro;
- Petrucelli, Leonard;
- Nishihara, Masugi;
- Hutton, Michael L.;
- McGowan, Eileen;
- Dickson, Dennis W.;
- Lewis, Jada
Publication type:
Abstract
Neuropathological characterization of progranulin-deficient mice: Accelerated lipofuscin accumulation suggests a role for progranulin in successful aging
Published in:
2009
By:
- Lewis, Jada M.;
- Ahmed, Zeshan;
- Sheng, Hong;
- Xu, Ya-Fei;
- Lin, Wen-Lang;
- Innes, Amy;
- Hou, Harold;
- Hutton, Michael L.;
- McGowan, Eileen;
- Dickson, Dennis W.
Publication type:
Abstract
O4-06-02: Reversible dendritic spine degeneration and compensatory filopodial extension in a conditional mutant tauopathy model
Published in:
2008
By:
- Andorfer, Cathy A.;
- Lin, Wen-Lang;
- Song, John;
- West, Gemma;
- Yue, Mei;
- Gan, Wen-Biao;
- Golde, Todd E.;
- Hutton, Mike;
- Lewis, Jada
Publication type:
Abstract
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.
Published in:
Nature Genetics, 2000, v. 25, n. 4, p. 402, doi. 10.1038/78078
By:
- Lewis, Jada;
- McGowan, Eileen;
- Rockwood, Julia;
- Melrose, Heather;
- Nacharaju, Parimala;
- Van Slegtenhorst, Marjon;
- Gwinn-Hardy, Katrina;
- Murphy, M. P;
- Baker, Matt;
- Yu, Xin;
- Duff, Karen;
- Hardy, John;
- Corral, Anthony;
- Lin, Wen-Lang;
- Yen, Shu-Hui;
- Dickson, Dennis W.;
- Davies, Peter;
- Hutton, Mike
Publication type:
Article
Casein Kinase II Induced Polymerization of Soluble TDP-43 into Filaments Is Inhibited by Heat Shock Proteins.
Published in:
PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090452
By:
- Carlomagno, Yari;
- Zhang, Yongjie;
- Davis, Mary;
- Lin, Wen-Lang;
- Cook, Casey;
- Dunmore, Judy;
- Tay, William;
- Menkosky, Kyle;
- Cao, Xiangkun;
- Petrucelli, Leonard;
- DeTure, Michael
Publication type:
Article
Alterations in surface morphology caused by centrifugation of cells fixed with glutaraldehyde.
Published in:
Scanning, 1983, v. 5, n. 4, p. 184, doi. 10.1002/sca.4950050403
By:
- Lin, Wen-Lang;
- Hoyer, L. C.;
- Bucana, C.
Publication type:
Article
ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.
Published in:
Nature Communications, 2014, v. 5, n. 6, p. 3996, doi. 10.1038/ncomms4996
By:
- Stoica, Radu;
- De Vos, Kurt J.;
- Paillusson, Sébastien;
- Mueller, Sarah;
- Sancho, Rosa M.;
- Lau, Kwok-Fai;
- Vizcay-Barrena, Gema;
- Lin, Wen-Lang;
- Xu, Ya-Fei;
- Lewis, Jada;
- Dickson, Dennis W.;
- Petrucelli, Leonard;
- Mitchell, Jacqueline C.;
- Shaw, Christopher E.;
- Miller, Christopher C. J.
Publication type:
Article
FTDP-17 with Pick body-like inclusions associated with a novel tau mutation, p.E372G.
Published in:
Brain Pathology, 2017, v. 27, n. 5, p. 612, doi. 10.1111/bpa.12428
By:
- Tacik, Pawel;
- DeTure, Michael A.;
- Carlomagno, Yari;
- Lin, Wen‐Lang;
- Murray, Melissa E.;
- Baker, Matthew C.;
- Josephs, Keith A.;
- Boeve, Bradley F.;
- Wszolek, Zbigniew K.;
- Graff‐Radford, Neill R.;
- Parisi, Joseph E.;
- Petrucelli, Leonard;
- Rademakers, Rosa;
- Isaacson, Richard S.;
- Heilman, Kenneth M.;
- Petersen, Ronald C.;
- Dickson, Dennis W.;
- Kouri, Naomi
Publication type:
Article
Multiple System Atrophy: A Sporadic Synucleinopathy.
Published in:
Brain Pathology, 1999, v. 9, n. 4, p. 721, doi. 10.1111/j.1750-3639.1999.tb00553.x
By:
- Dickson, Dennis W.;
- Lin, Wen-lang;
- Liu, Wan-Kyun;
- Yen, Shu-Hui
Publication type:
Article
TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease.
Published in:
2007
By:
- Amador-Ortiz C;
- Lin WL;
- Ahmed Z;
- Personett D;
- Davies P;
- Duara R;
- Graff-Radford NR;
- Hutton ML;
- Dickson DW;
- Amador-Ortiz, Catalina;
- Lin, Wen-Lang;
- Ahmed, Zeshan;
- Personett, David;
- Davies, Peter;
- Duara, Ranjan;
- Graff-Radford, Neill R;
- Hutton, Michael L;
- Dickson, Dennis W
Publication type:
journal article
Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy.
Published in:
Human Molecular Genetics, 2019, v. 28, n. 19, p. 3255, doi. 10.1093/hmg/ddz151
By:
- Koller, Emily J;
- Cruz, Elsa Gonzalez De La;
- Machula, Timothy;
- Ibanez, Kristen R;
- Lin, Wen-Lang;
- Williams, Tosha;
- Riffe, Cara J;
- Ryu, Daniel;
- Strang, Kevin H;
- Liu, Xuefei;
- Janus, Christopher;
- Golde, Todd E;
- Dickson, Dennis;
- Giasson, Benoit I;
- Chakrabarty, Paramita
Publication type:
Article
The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons.
Published in:
Human Molecular Genetics, 2013, v. 22, n. 23, p. 4706, doi. 10.1093/hmg/ddt319
By:
- Wang, Wenzhang;
- Li, Li;
- Lin, Wen-Lang;
- Dickson, Dennis W.;
- Petrucelli, Leonard;
- Zhang, Teng;
- Wang, Xinglong
Publication type:
Article
p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration.
Published in:
PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0169291
By:
- Jackson, Kasey L.;
- Lin, Wen-Lang;
- Miriyala, Sumitra;
- Dayton, Robert D.;
- Panchatcharam, Manikandan;
- McCarthy, Kevin J.;
- Castanedes-Casey, Monica;
- Dickson, Dennis W.;
- Klein, Ronald L.
Publication type:
Article
A novel tau mutation, p.K317N, causes globular glial tauopathy.
Published in:
Acta Neuropathologica, 2015, v. 130, n. 2, p. 199, doi. 10.1007/s00401-015-1425-0
By:
- Tacik, Pawel;
- DeTure, Michael;
- Lin, Wen-Lang;
- Sanchez Contreras, Monica;
- Wojtas, Aleksandra;
- Hinkle, Kelly;
- Fujioka, Shinsuke;
- Baker, Matthew;
- Walton, Ronald;
- Carlomagno, Yari;
- Brown, Patricia;
- Strongosky, Audrey;
- Kouri, Naomi;
- Murray, Melissa;
- Petrucelli, Leonard;
- Josephs, Keith;
- Rademakers, Rosa;
- Ross, Owen;
- Wszolek, Zbigniew;
- Dickson, Dennis
Publication type:
Article
A truncating SOD1 mutation, p.Gly141X, is associated with clinical and pathologic heterogeneity, including frontotemporal lobar degeneration.
Published in:
2015
By:
- Nakamura, Masataka;
- Bieniek, Kevin;
- Lin, Wen-Lang;
- Graff-Radford, Neill;
- Murray, Melissa;
- Castanedes-Casey, Monica;
- Desaro, Pamela;
- Baker, Matthew;
- Rutherford, Nicola;
- Robertson, Janice;
- Rademakers, Rosa;
- Dickson, Dennis;
- Boylan, Kevin
Publication type:
Report
Atypical multiple system atrophy is a new subtype of frontotemporal lobar degeneration: frontotemporal lobar degeneration associated with α-synuclein.
Published in:
Acta Neuropathologica, 2015, v. 130, n. 1, p. 93, doi. 10.1007/s00401-015-1442-z
By:
- Aoki, Naoya;
- Boyer, Philip;
- Lund, Cheryl;
- Lin, Wen-Lang;
- Koga, Shunsuke;
- Ross, Owen;
- Weiner, Myron;
- Lipton, Anne;
- Powers, James;
- White, Charles;
- Dickson, Dennis
Publication type:
Article
Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress.
Published in:
Acta Neuropathologica, 2014, v. 128, n. 4, p. 505, doi. 10.1007/s00401-014-1336-5
By:
- Zhang, Yong-Jie;
- Jansen-West, Karen;
- Xu, Ya-Fei;
- Gendron, Tania;
- Bieniek, Kevin;
- Lin, Wen-Lang;
- Sasaguri, Hiroki;
- Caulfield, Thomas;
- Hubbard, Jaime;
- Daughrity, Lillian;
- Chew, Jeannie;
- Belzil, Veronique;
- Prudencio, Mercedes;
- Stankowski, Jeannette;
- Castanedes-Casey, Monica;
- Whitelaw, Ena;
- Ash, Peter;
- DeTure, Michael;
- Rademakers, Rosa;
- Boylan, Kevin
Publication type:
Article
Concurrent variably protease-sensitive prionopathy and amyotrophic lateral sclerosis.
Published in:
2014
By:
- Cannon, Ashley;
- Bieniek, Kevin;
- Lin, Wen-Lang;
- Notari, Silvio;
- Zou, Wen-Quan;
- Gambetti, Pierluigi;
- Pedraza, Otto;
- Graff-Radford, Neill;
- Ferman, Tanis;
- Dickson, Dennis
Publication type:
Letter
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
Published in:
Acta Neuropathologica, 2013, v. 126, n. 1, p. 39, doi. 10.1007/s00401-013-1123-8
By:
- Clippinger, Amy;
- D'Alton, Simon;
- Lin, Wen-Lang;
- Gendron, Tania;
- Howard, John;
- Borchelt, David;
- Cannon, Ashley;
- Carlomagno, Yari;
- Chakrabarty, Paramita;
- Cook, Casey;
- Golde, Todd;
- Levites, Yona;
- Ranum, Laura;
- Schultheis, Patrick;
- Xu, Guilian;
- Petrucelli, Leonard;
- Sahara, Naruhiko;
- Dickson, Dennis;
- Giasson, Benoit;
- Lewis, Jada
Publication type:
Article
Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Published in:
Acta Neuropathologica, 2012, v. 123, n. 6, p. 807, doi. 10.1007/s00401-012-0979-3
By:
- Cannon, Ashley;
- Yang, Baoli;
- Knight, Joshua;
- Farnham, Ian;
- Zhang, Yongjie;
- Wuertzer, Charles;
- D'Alton, Simon;
- Lin, Wen-lang;
- Castanedes-Casey, Monica;
- Rousseau, Linda;
- Scott, Brittany;
- Jurasic, Michael;
- Howard, John;
- Yu, Xin;
- Bailey, Rachel;
- Sarkisian, Matthew;
- Dickson, Dennis;
- Petrucelli, Leonard;
- Lewis, Jada
Publication type:
Article
Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of Fluid.
Published in:
Cells (2073-4409), 2018, v. 7, n. 12, p. 273, doi. 10.3390/cells7120273
By:
- Busatto, Sara;
- Vilanilam, George;
- Ticer, Taylor;
- Lin, Wen-Lang;
- Dickson, Dennis W.;
- Shapiro, Shane;
- Bergese, Paolo;
- Wolfram, Joy
Publication type:
Article
Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression.
Published in:
European Journal of Neuroscience, 2008, v. 27, n. 5, p. 1119, doi. 10.1111/j.1460-9568.2008.06084.x
By:
- Hamano, Tadanori;
- Gendron, Tania F.;
- Causevic, Ena;
- Yen, Shu‐Hui;
- Lin, Wen‐Lang;
- Isidoro, Ciro;
- DeTure, Michael;
- Ko, Li‐wen
Publication type:
Article

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