Results
Title

Human umbilical cord blood serum attenuates gentamicin‐induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats.

Authors

Mirazi, Naser; Baharvand, Fatemeh; Moghadasali, Reza; Nourian, Alireza; Hosseini, Abdolkarim

Abstract

Gentamicin (GM) is an aminoglycoside antibiotic that despite its antibacterial effects, its use is restricted due to numerous side effects. The umbilical cord serum contains various biomolecules that have protective impacts on the damaged tissues. The aim of this study was to gauge the protective effect of human umbilical cord blood serum (hUCBS) on GM‐induced hepatotoxicity. In this experimental study, 28 male Wistar rats, weighing 220 ± 20 g, were randomly categorized into 4 groups including control, GM (100 mg/kg), hUCBS at doses of 1 and 2% along with GM (100 mg/kg) for 10 days, intraperitoneally. Twenty‐four hours after the last injection, direct blood sampling was taken from the heart to obtain blood serum and liver enzymes, inflammatory cytokines and liver tissue were examined for histology. GM causes necrosis and inflammation in liver tissue. Liver enzyme and inflammatory cytokine levels were significantly increased in the GM group. Human umbilical cord blood serum significantly decreased liver enzyme and inflammatory cytokines levels in the experimental groups compared to the GM group. GM causes liver damage such as the inflammation and necrosis in liver tissue. Treating the animals with hUCBS reduced the toxic effects of GM in the liver.

Subjects

CORD blood; SERUM; HEPATITIS; LIVER enzymes; UMBILICAL cord; HEPATOTOXICOLOGY; LIVER histology

Publication

Basic & Clinical Pharmacology & Toxicology, 2021, Vol 128, Issue 2, p268

ISSN

1742-7835

Publication type

Academic Journal

DOI

10.1111/bcpt.13502