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Title

Interaction of OTC drug noscapine and acenocoumarol and phenprocoumon.

Authors

Lokhorst, Bianca; Rolfes, Leàn; Jessurun, Naomi T.

Abstract

The article presents a study exploring the interaction of over-the-counter (OTC) drug noscapine and acenocoumarol and phenprocoumon. Topics discussed include information on the anticoagulant effects of the drugs by inhibiting the synthesis of vitamin K–dependent clotting factors; determining the nature of the drug interaction between noscapine and warfarin; and the information on the interaction between vitamin K antagonists and noscapine resulting in increased international normalized ratio.

Subjects

NONPRESCRIPTION drugs; NOSCAPINE; DRUG interactions; BLOOD coagulation factors; WARFARIN; INTERNATIONAL normalized ratio

Publication

British Journal of Clinical Pharmacology, 2019, Vol 85, Issue 5, p1041

ISSN

0306-5251

Publication type

Academic Journal

DOI

10.1111/bcp.13887

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