This article discusses adult food protein-induced enterocolitis syndrome (FPIES), a non-IgE mediated food allergy. It highlights that adult-onset FPIES may present differently than pediatric FPIES, with vomiting being absent in up to 40% of adults. The article proposes an algorithm for the diagnosis and management of adult FPIES, which includes a thorough clinical history, oral food challenges (OFCs), and symptom-directed treatment. It also emphasizes the importance of ruling out other conditions and recommends personalized avoidance diets for patients with confirmed FPIES. The article aims to provide guidance on recognizing and managing adult FPIES.