This case study presents a rare and aggressive tumor called undifferentiated embryonal sarcoma of the liver (UESL). The study focuses on a 46-year-old female patient who was diagnosed with UESL and underwent surgical removal of the tumor followed by adjuvant chemotherapy. However, the patient experienced recurrence and disease progression. The study suggests that further molecular and genomic analysis may be beneficial in identifying markers for tumor response to systemic therapy and developing future treatments for UESL. This information provides valuable insights for clinicians and researchers studying UESL.