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- Title
Association between renal α‐klotho and renal pathology among patients with chronic kidney disease.
- Authors
Guo, Yan; Wan, Feng; Shi, Yan‐peng; Zhang, Hong‐mei; Yang, Ru‐chun
- Abstract
Introduction: This study was designed to investigate whether renal α‐klotho levels are associated with renal pathology. This is the first report on patients with chronic kidney disease (CKD). Methods: We conducted a retrospective observational study. A total of 65 CKD patients were enrolled. Serum and renal biopsy samples were collected. Estimated glomerular filtration rate (eGFR) was examined by biochemical test. And α‐klotho expressions were assessed by RT‐PCR and immunohistochemistry. In addition, detailed microscopic findings were reviewed. Results: Renal α‐klotho levels are associated positively with eGFR, and negatively with renal pathology, including interstitial fibrosis, inflammatory cell infiltration, and tubular atrophy. Conclusions: The renal α‐klotho is related to renal pathology.
- Subjects
CHRONIC kidney failure; GLOMERULAR filtration rate; CHRONICALLY ill; RENAL biopsy; EPIDERMAL growth factor receptors
- Publication
Therapeutic Apheresis & Dialysis, 2024, Vol 28, Issue 5, p769
- ISSN
1744-9979
- Publication type
Academic Journal
- DOI
10.1111/1744-9987.14165