Results
Title

The impact of flaxseed oil on lipid profiles, weight loss, and inflammatory markers in hemodialysis patients: A systematic review and meta‐analysis of randomized controlled trials.

Authors

Tabrizi, Reza; Azizi, Zahra; Bazmi, Sina; Keshavarzian, Omid; Akbari, Maryam; Karimimoghadam, Zeinab; Haghpanah, Abdolreza

Abstract

Studies investigating the effects of flaxseed oil on lipid profiles, weight loss, and inflammatory markers have produced inconsistent results. This systematic review and meta‐analysis of randomized controlled trials (RCTs) aimed to explore the impact of flaxseed oil on these parameters in hemodialysis patients. The study protocol was registered online (PROSPERO number: CRD42023484076). The meta‐analyses showed a significant decrease in triglyceride (TG) levels (WMD = −85.78 mg/dL, 95% CI: −155.24 to −16.32, I2 = 98.32%) and C‐reactive protein (CRP) levels (WMD = −2.66 mg/L, 95% CI: −4.07 to −1.24, I2 = 92.26%) following consumption of flaxseed oil. Subgroup analyses revealed significant changes in LDL‐C, HDL‐C, and TC levels only in trials utilizing a dosage higher than 10 g per day and using ground flaxseed oil. Based on the results, flaxseed oil improves CRP and TG levels, and higher doses positively affect lipid profiles. However, it has no significant effect on anthropometric measures.

Subjects

LINSEED oil; RANDOMIZED controlled trials; WEIGHT loss; HEMODIALYSIS patients; DYSLIPIDEMIA; LIPIDS

Publication

Therapeutic Apheresis & Dialysis, 2024, Vol 28, Issue 4, p534

ISSN

1744-9979

Publication type

Academic Journal

DOI

10.1111/1744-9987.14140