Retrospective review of Prothrombinex use by SAAS MedSTAR.

Fischer, Roy; Brettig, Simon; Pearce, Andrew

Objective The aim of this study was to review and describe the use of Prothrombinex by a physician-led retrieval service based remote from a hospital blood bank. Methods This is a retrospective observational study. Patients to whom Prothrombinex was administered by the retrieval team were identified from the retrieval service patient database. The paper case cards of the identified patients were then manually reviewed and the data matched to patients in the state-wide electronic laboratory record. Results Between 1 January 2010 and 30 November 2013 38 cases were identified. For 28 the indication was warfarinisation associated with life-threatening bleeding (most commonly intracranial or gastrointestinal tract). In the remaining 10 cases, Prothrombinex was used to treat coagulopathy associated with liver disease or massive haemorrhage. The median time saved by the retrieval team administering PTX-VF, rather than waiting to the receiving centre, was 120 min (interquartile range: 85-195 min). The median dose of PTX-VF administered was 23.25 IU/kg (interquartile range: 20-33 IU/kg). Paired international normalised ratios (INRs) were available for 33 of the 38 patients. In the warfarin group, all patients had an improvement in their INR and 21 of 25 had correction of their INR. In the non-warfarin group, the effect on INR was more variable. Conclusion Prothrombinex is a clinically useful product that can be relatively easily stored and used by retrieval services, even if they are based in isolation from a hospital blood bank. More research is required to look at the utility of Prothrombinex for non-warfarin-related bleeding in the pre-hospital and retrieval environment.

BLOOD banks; BLOOD coagulation factors; ECOLOGY; ELECTRONICS; FISHER exact test; GASTROINTESTINAL system; HOSPITALS; LABORATORIES; SCIENTIFIC observation; WARFARIN; COMPUTER systems; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics; INTERNATIONAL normalized ratio; MANN Whitney U Test

Emergency Medicine Australasia, 2017, Vol 29, Issue 2, p178

1742-6731

Academic Journal

10.1111/1742-6723.12710