Title: The Composition of the Ceramides from Human Stratum Corneum and from Comedones.
Authors: Wertz, Philip W.; Miethke, Marion C.; Long, Sherri A.; Strauss, John S.; Downing, Donald T.
Abstract: Human epidermal surface lipids were collected by an ethanol wash and the ceramides were quantified by thin-layer chromatography-photodensitometry. Six ceramide fractions were isolated and the structural components of each were analyzed in detail. The most unusual of the epidermal ceramides contained a sphingosine base with amide-linked 30- and 32-carbon ω-hydroxyacids and an ester-linked nonhydroxyacid, 41% of which was linoleic acid. The proportion of linoleic acid in the analogous ceramide from comedones was 6%. This supports the hypothesis that a localized insufficiency of linoleic acid in the follicular epithelium is an etiologic factor in comedogenesis.
Subjects: LIPIDS; CHROMATOGRAPHIC analysis; EPIDERMIS; ALCOHOL; CERAMIDES; SPHINGOSINE; LINOLEIC acid
Publication: Journal of Investigative Dermatology, 1985, Vol 84, Issue 5, p410
ISSN: 0022-202X
Publication type: Academic Journal
DOI: 10.1111/1523-1747.ep12265510

The Composition of the Ceramides from Human Stratum Corneum and from Comedones.

Wertz, Philip W.; Miethke, Marion C.; Long, Sherri A.; Strauss, John S.; Downing, Donald T.