Works matching DE "UNFOLDED protein response"

Results: 1566

Incretin Mimetics Restore the ER-Mitochondrial Axis and Switch Cell Fate Towards Survival in LUHMES Dopaminergic-Like Neurons: Implications for Novel Therapeutic Strategies in Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2023, v. 13, n. 7, p. 1149, doi. 10.3233/JPD-230030

By:

Panagaki, Theodora;
Randi, Elisa B.;
Szabo, Csaba;
Hölscher, Christian

Publication type:

Article

Endoplasmic Reticulum Stress Regulators: New Drug Targets for Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2021, v. 11, p. S219, doi. 10.3233/JPD-212673

By:

Kovaleva, Vera;
Saarma, Mart;
Björklund, Anders;
Bloem, Bastiaan R.;
Brundin, Patrik;
Federoff, Howard

Publication type:

Article

Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation Underlie Silver Nanoparticles‐Induced Neurologic Deficits in Adult Mice.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 6, p. 1, doi. 10.1002/jbt.70289

By:

Zhang, Wenhui;
Zhai, Mengdi;
Wu, Meijia;
Yuan, Yongke;
Su, Xiao;
Yang, Mingzhi;
Ba, Yue;
Deng, Qihong;
Zhang, Yu;
Han, Lin;
Gao, Lihua;
Huang, Hui

Publication type:

Article

Metformin modulates the unfolded protein responses, altering lifespan and health-promoting effects in UPR-activated worms.

Published in:

PLoS ONE, 2025, v. 20, n. 6, p. 1, doi. 10.1371/journal.pone.0326100

By:

Tan, Jerald;
Chiamkunakorn, Chutipong;
Boonchuay, Kanpapat;
Shi, Yiying;
Braeckman, Bart P.;
Suthammarak, Wichit

Publication type:

Article

Neocarzilin A induces apoptosis and mitochondrial disturbance by targeting reticulon 4-mediated endoplasmic reticulum stress.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02560-3

By:

Jauch, A. T.;
Sailer, J.;
Braun, J.;
Czeslik, E.;
Geyer, J.;
Eberhagen, C.;
Vollmar, A. M.;
Zischka, H.;
Sieber, S. A.;
Zahler, S.

Publication type:

Article

Therapeutic potential of BOLD-100, a GRP78 inhibitor, enhanced by ATR inhibition in pancreatic ductal adenocarcinoma.

Published in:

Cell Communication & Signaling, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12964-025-02242-8

By:

Lee, Su In;
Nam, Ah-Rong;
Oh, Kyoung-Seok;
Kim, Jae-Min;
Bang, Ju-Hee;
Jeong, Yoojin;
Choo, Sea Young;
Kim, Hyo Jung;
Yoon, Jeesun;
Kim, Tae-Yong;
Oh, Do-Youn

Publication type:

Article

Novel insights into beta cell ER stress CHOP and its role in HFpEF development.

Published in:

Cardiovascular Diabetology, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12933-025-02703-x

By:

Srinivas, Balaji;
Fortuno, Paula;
Peng, Hongmei;
Xu, Jiang;
Suhail, Hamid;
Sabbah, Hani N.;
Rhaleb, Nour-Eddine;
Matrougui, Khalid

Publication type:

Article

Prognostic role of eIF2α protein in metastatic renal cell cancer patients.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02916-2

By:

Ekinci, Ferhat;
Mavili, Hanife Seda;
Neşe, Nalan;
Erdoğan, Atike Pınar;
Demir, Bilgin;
Oktay, Esin;
Çulhacı, Nil;
Uzun, Mehmet;
Karaoğlu, Aziz;
Yörükoğlu, Kutsal;
Tuna, Emine Burçin;
Dirican, Ahmet

Publication type:

Article

Mechanisms on How Matricellular Microenvironments Sustain Idiopathic Pulmonary Fibrosis.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5393, doi. 10.3390/ijms26115393

By:

Jones, Nicole;
Rahar, Babita;
Bernau, Ksenija;
Schulte, Jefree J.;
Campagnola, Paul J.;
Brasier, Allan R.

Publication type:

Article

Cellular and Transcriptional Responses of Human Bronchial Epithelial Cells to Delta-9-Tetrahydrocannabinol In Vitro.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5212, doi. 10.3390/ijms26115212

By:

Doldron, Megan S.;
Chakraborty, Sourav;
Anand, Santosh;
Faheem, Mehwish;
Reh, Beh;
Wang, Xuegeng;
Mallik, Saurav;
Jia, Zhenquan;
Bhandari, Ramji Kumar

Publication type:

Article

Modulation of ER Stress and Inflammation by S-Ketamine, R-Ketamine, and Their Metabolites in Human Microglial Cells: Insights into Novel Targets for Depression Therapy.

Published in:

Cells (2073-4409), 2025, v. 14, n. 11, p. 831, doi. 10.3390/cells14110831

By:

Jóźwiak-Bębenista, Marta;
Wiktorowska-Owczarek, Anna;
Siatkowska, Małgorzata;
Komorowski, Piotr;
Włodarczyk, Aneta;
Kowalczyk, Edward;
Sokołowska, Paulina

Publication type:

Article

VPAC1 and VPAC2 Receptor Heterozygosity Confers Distinct Biological Properties to BV2 Microglial Cells.

Published in:

Cells (2073-4409), 2025, v. 14, n. 11, p. 769, doi. 10.3390/cells14110769

By:

Song, Xin Ying Rachel;
Jansen, Margo Iris;
Marzagalli, Rubina;
Musumeci, Giuseppe;
D'Agata, Velia;
Castorina, Alessandro

Publication type:

Article

Albendazole specifically disrupts microtubules and protein turnover in the tegument of the cestode Mesocestoides corti.

Published in:

PLoS Pathogens, 2025, v. 21, n. 6, p. 1, doi. 10.1371/journal.ppat.1013221

By:

Guarnaschelli, Inés;
Koziol, Uriel

Publication type:

Article

VPS13D mutations affect mitochondrial homeostasis and locomotion in Caenorhabditis elegansOpen Access.

Published in:

G3: Genes | Genomes | Genetics, 2025, v. 15, n. 4, p. 1, doi. 10.1093/g3journal/jkaf023

By:

Yin, Xiaomeng;
Wang, Ruoxi;
Thackeray, Andrea;
Baehrecke, Eric H;
Alkema, Mark J

Publication type:

Article

Redistribution of Ancestral Functions Underlies the Evolution of Venom Production in Marine Predatory Snails Open Access.

Published in:

Molecular Biology & Evolution, 2025, v. 42, n. 5, p. 1, doi. 10.1093/molbev/msaf095

By:

Zancolli, Giulia;
Modica, Maria Vittoria;
Puillandre, Nicolas;
Kantor, Yuri;
Barua, Agneesh;
Campli, Giulia;
Robinson-Rechavi, Marc

Publication type:

Article

Reduced Expression of UPRmt Proteins HSP10, HSP60, HTRA2, OMA1, SPG7, and YME1L Is Associated with Accelerated Heart Failure in Humans.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1142, doi. 10.3390/biomedicines13051142

By:

Bakovic, Petra;
Mirosevic, Vid;
Svagusa, Tomo;
Sepac, Ana;
Kulic, Ana;
Milicic, Davor;
Gasparovic, Hrvoje;
Rudez, Igor;
Urlic, Marjan;
Sikiric, Suncana;
Seiwerth, Sven;
Belina, Drazen;
Bakos, Matija;
Vlahovic, Monika Karija;
Taradi, Rea;
Zic, Rado;
Ilic, Ivana;
Belev, Borislav;
Skoric, Bosko;
Fabijanovic, Dora

Publication type:

Article

Orf132: a critical gene for LSDV replication and its role in Er stress-related apoptosis.

Published in:

Virology Journal, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12985-025-02813-8

By:

Wang, Yongtao;
Zhang, Shiwei;
Li, Hailing;
Feng, Yali;
Zhang, Ying

Publication type:

Article

The Microbiome in Bronchial Biopsies from Smokers and Ex-Smokers with Stable COPD - A Metatranscriptomic Approach.

Published in:

COPD: Journal of Chronic Obstructive Pulmonary Disease, 2022, v. 19, n. 1, p. 81, doi. 10.1080/15412555.2022.2033193

By:

Ditz, B.;
Boekhoudt, J.;
Couto, N.;
Brandsma, C. A.;
Hiemstra, P. S.;
Tew, G. W.;
Neighbors, M.;
Grimbaldeston, M. A.;
Timens, W.;
Kerstjens, H. A. M.;
Rossen, J. W. A.;
Guryev, V.;
van den Berge, M.;
Faiz, A.

Publication type:

Article

Endoplasmic reticulum in oocytes: spatiotemporal distribution and function.

Published in:

Journal of Assisted Reproduction & Genetics, 2023, v. 40, n. 6, p. 1255, doi. 10.1007/s10815-023-02782-3

By:

Kang, Xin;
Wang, Jing;
Yan, Liying

Publication type:

Article

Unraveling the crucial role of UPR pathway in rat brain development.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10483-6

By:

Jiang, Yan;
Wang, Ajun;
Zou, Nian;
Dai, Huimin;
Shan, Ran;
Ren, Siyu;
Jiang, Tongcui;
Li, Nan

Publication type:

Article

Skeletal muscle atrophy induced by aging and disuse atrophy are strongly associated with the upregulation of the endoplasmic stress protein CHOP in rats.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10415-4

By:

Michel, J. Max;
Godwin, Joshua S.;
Kerr, Nathan R.;
Childs, Thomas E.;
Booth, Frank W.;
Mobley, C. Brooks;
Hughes, David C.;
Roberts, Michael D.

Publication type:

Article

Therapeutic potential of aquatic Stevia extract in alleviating endoplasmic reticulum stress and liver damage in streptozotocin-induced diabetic rats.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09907-6

By:

Saadi, Hediye Fahandezh;
Zamani, Mozhdeh;
Koohpeyma, Farhad;
Raeisi, Alireza;
Amirahmadi, Zahra;
Rezaei, Narges;
Joolidehpoor, Zahra;
Shams, Mesbah;
Dastghaib, Sanaz

Publication type:

Article

β-Hydroxybutyrate and melatonin suppress maladaptive UPR, excessive autophagy and pyroptosis in Aβ 1–42 and LPS-Induced SH-SY5Y cells.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09754-5

By:

Maleki, Mohammad Hasan;
Omidi, Fatemeh;
Javanshir, Zeinab;
Bagheri, Mahla;
Tanhadoroodzani, Zobeideh;
Dastghaib, Sahar;
Shams, Mesbah;
Akbari, Mohammadarian;
Dastghaib, Sanaz

Publication type:

Article

The modulation of autophagy and unfolded protein response by ent-kaurenoid derivative CPUK02 in human colorectal cancer cells.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09541-2

By:

Rezayi, Sedigheh;
Siri, Morvarid;
Rahmani-Kukia, Nasim;
Zamani, Mozhdeh;
Dastghaib, Sanaz;
Mokarram, Pooneh

Publication type:

Article

Zinc ions negatively regulate proapoptotic signaling in cells expressing oncogenic mutant Ras.

Published in:

BioMetals, 2022, v. 35, n. 2, p. 349, doi. 10.1007/s10534-022-00376-7

By:

Edamatsu, Hironori

Publication type:

Article

Enhancing healthy aging with small molecules: A mitochondrial perspective.

Published in:

Medicinal Research Reviews, 2024, v. 44, n. 4, p. 1904, doi. 10.1002/med.22034

By:

Qin, Xiujiao;
Li, Hongyuan;
Zhao, Huiying;
Fang, Le;
Wang, Xiaohui

Publication type:

Article

ER stress and inflammation crosstalk in obesity.

Published in:

Medicinal Research Reviews, 2023, v. 43, n. 1, p. 5, doi. 10.1002/med.21921

By:

Ajoolabady, Amir;
Lebeaupin, Cynthia;
Wu, Ne N.;
Kaufman, Randal J.;
Ren, Jun

Publication type:

Article

FUS and METTL3 collaborate to regulate RNA maturation, preventing unfolded protein response and promoting gastric cancer progression.

Published in:

Clinical & Experimental Medicine, 2024, v. 25, n. 1, p. 1, doi. 10.1007/s10238-024-01525-7

By:

Liu, Dongtao;
Ding, Bo;
Liu, Gang;
Yang, Zhijuan

Publication type:

Article

N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties.

Published in:

Amino Acids, 2021, v. 53, n. 12, p. 1927, doi. 10.1007/s00726-021-03012-9

By:

Scott, Gary K.;
Mahoney, Sophia;
Scott, Madeleine;
Loureiro, Ashley;
Lopez-Ramirez, Alejandro;
Tanner, John J.;
Ellerby, Lisa M.;
Benz, Christopher C.

Publication type:

Article

β-Methylamino-L-alanine-induced protein aggregation in vitro and protection by L-serine.

Published in:

Amino Acids, 2021, v. 53, n. 9, p. 1351, doi. 10.1007/s00726-021-03049-w

By:

Quinn, Adam W.;
Phillips, Connor R.;
Violi, Jake P.;
Steele, Joel R.;
Johnson, Michael S.;
Westerhausen, Mika T.;
Rodgers, Kenneth J.

Publication type:

Article

Epibrassinolide-induced autophagy occurs in an Atg5-independent manner due to endoplasmic stress induction in MEF cells.

Published in:

Amino Acids, 2020, v. 52, n. 6/7, p. 871, doi. 10.1007/s00726-020-02857-w

By:

Adacan, Kaan;
Obakan-Yerlikaya, Pınar;
Arisan, Elif Damla;
Coker-Gurkan, Ajda;
Kaya, Resul Ismail;
Palavan-Unsal, Narçın

Publication type:

Article

Endoplasmic Reticular Stress and Pathogenesis of Experimental Colitis: Mechanism of Action of 5-Amino Salicylic Acid.

Published in:

Medical Principles & Practice, 2025, v. 34, n. 1, p. 39, doi. 10.1159/000541791

By:

Baydoun, Zahraa A.;
Rao, Muddanna;
Khan, Islam

Publication type:

Article

Opposing regulation of endoplasmic reticulum retention under stress by ERp44 and PDIA6.

Published in:

Biochemical Journal, 2024, v. 481, n. 24, p. 1921, doi. 10.1042/BCJ20240444

By:

Yassin, Olaya;
Praveen, Bellam;
Darawshi, Odai;
LaFramboise, Thomas;
Shmuel, Miriam;
Pattanayak, Shakti P.;
Law, Brian K.;
Hatzoglou, Maria;
Tirosh, Boaz

Publication type:

Article

Structural and molecular bases to IRE1 activity modulation.

Published in:

Biochemical Journal, 2021, v. 478, n. 15, p. 2953, doi. 10.1042/BCJ20200919

By:

Langlais, Timothy;
Pelizzari-Raymundo, Diana;
Mahdizadeh, Sayyed Jalil;
Gouault, Nicolas;
Carreaux, Francois;
Chevet, Eric;
Eriksson, Leif A.;
Guillory, Xavier

Publication type:

Article

FATP4 inactivation in cultured macrophages attenuates M1- and ER stress-induced cytokine release via a metabolic shift towards triacylglycerides.

Published in:

Biochemical Journal, 2021, v. 478, n. 10, p. 1861, doi. 10.1042/BCJ20210155

By:

Yuling Zhang;
Ning Wu;
Hongying Gan-Schreier;
Feng Xu;
Tuma-Kellner, Sabine;
Staffer, Simone;
Seeßle, Jessica;
Merle, Uta;
Chamulitrat, Walee

Publication type:

Article

MoSey1 regulates the unfolded protein response, appressorium development, and pathogenicity of Magnaporthe oryzae.

Published in:

Phytopathology Research, 2024, v. 6, n. 1, p. 1, doi. 10.1186/s42483-024-00253-w

By:

Yang, Zifeng;
Li, Meiqin;
Huang, Linwan;
Chen, Xinru;
Weng, Shuning;
Jules, Biregeya;
Felix, Abah;
Zheng, Huakun;
Chen, Xiaofeng;
Zhang, Jun;
Wang, Zonghua;
Cai, Yingying;
Liang, Jingang;
Tang, Wei

Publication type:

Article

Advanced genomics identifies growth effectors for proteotoxic ER stress recovery in Arabidopsis thaliana.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-021-02964-8

By:

Ko, Dae Kwan;
Brandizzi, Federica

Publication type:

Article

Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02460-z

By:

Pei, Sen;
Swayne, Theresa C.;
Morris, Jeffrey F.;
Emtage, Lesley

Publication type:

Article

Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02391-9

By:

Al-Yacoub, Nadya;
Colak, Dilek;
Mahmoud, Salma Awad;
Hammonds, Maya;
Muhammed, Kunhi;
Al-Harazi, Olfat;
Assiri, Abdullah M.;
Al-Buraiki, Jehad;
Al-Habeeb, Waleed;
Poizat, Coralie

Publication type:

Article

CRISPR-Cas9-Mediated ATF6B Gene Editing Enhances Membrane Protein Production in HEK293T Cells.

Published in:

Bioengineering (Basel), 2025, v. 12, n. 4, p. 409, doi. 10.3390/bioengineering12040409

By:

Choi, Ho Joong;
Kim, Ba Reum;
Kim, Ok-Hee;
Kim, Say-June

Publication type:

Article

Connections Between Endoplasmic Reticulum Stress and Prognosis of Hepatocarcinoma.

Published in:

Bioengineering (Basel), 2024, v. 11, n. 11, p. 1136, doi. 10.3390/bioengineering11111136

By:

Wu, Ming;
Yan, Jinxing;
Qin, Shimei;
Fu, Lei;
Sun, Shibin;
Li, Wan;
Lv, Junjie;
Chen, Lina

Publication type:

Article

Enhancing Antibody-Specific Productivity: Unraveling the Impact of XBP1s Overexpression and Glutamine Availability in SP2/0 Cells.

Published in:

Bioengineering (Basel), 2024, v. 11, n. 3, p. 201, doi. 10.3390/bioengineering11030201

By:

González-Pereira, Priscilla;
Trinh, Ryan;
Vasuthasawat, Alex;
Bartsch-Jiménez, Angelo;
Nuñez-Soto, Constanza;
Altamirano, Claudia

Publication type:

Article

Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua).

Published in:

Journal of Applied Toxicology, 2023, v. 43, n. 12, p. 1859, doi. 10.1002/jat.4519

By:

Olsvik, Pål A.;
Meier, Sonnich;
Zhang, Xiaokang;
Goksøyr, Anders;
Karlsen, Odd Andre;
Yadetie, Fekadu

Publication type:

Article

Heat Shock Factor HSFA6b Mediates Mitochondrial Unfolded Protein Response in Arabidopsis thaliana.

Published in:

Plants (2223-7747), 2024, v. 13, n. 22, p. 3116, doi. 10.3390/plants13223116

By:

Yu, Guolong;
Huang, Zhuoran;
Guo, Chaocheng;
Li, Jiahao;
Wang, Xinyuan;
Wang, Yudong;
Wang, Xu

Publication type:

Article

A View into Seed Autophagy: From Development to Environmental Responses.

Published in:

Plants (2223-7747), 2022, v. 11, n. 23, p. 3247, doi. 10.3390/plants11233247

By:

Iglesias-Fernández, Raquel;
Vicente-Carbajosa, Jesús

Publication type:

Article

ER Stress and the Unfolded Protein Response: Homeostatic Regulation Coordinate Plant Survival and Growth.

Published in:

Plants (2223-7747), 2022, v. 11, n. 23, p. 3197, doi. 10.3390/plants11233197

By:

Kim, June-Sik;
Mochida, Keiichi;
Shinozaki, Kazuo

Publication type:

Article

The Passage of H 2 O 2 from Chloroplasts to Their Associated Nucleus during Retrograde Signalling: Reflections on the Role of the Nuclear Envelope.

Published in:

Plants (2223-7747), 2022, v. 11, n. 4, p. 552, doi. 10.3390/plants11040552

By:

Breeze, Emily;
Mullineaux, Philip M.

Publication type:

Article

Deciphering the Proteotoxic Stress Responses Triggered by the Perturbed Thylakoid Proteostasis in Arabidopsis.

Published in:

Plants (2223-7747), 2021, v. 10, n. 3, p. 519, doi. 10.3390/plants10030519

By:

Nishimura, Kenji;
Nakagawa, Reiko;
Hachisuga, Chisato;
Nakajima Munekage, Yuri

Publication type:

Article

Lasers in Medicine: The Changing Role of Therapeutic Laser-Induced Retinal Damage—From de rigeuer to Nevermore.

Published in:

Photonics, 2023, v. 10, n. 9, p. 999, doi. 10.3390/photonics10090999

By:

Luttrull, Jeffrey K.

Publication type:

Article

Clemastine and hyperthermia enhance sensitization of osteosarcoma cells for apoptosis.

Published in:

Molecular & Cellular Oncology, 2024, v. 11, n. 1, p. 1, doi. 10.1080/23723556.2024.2351622

By:

Obu, Somtochukwu;
Niture, Suryakant;
Hoang, Hieu;
Gadi, Sashi;
Vandana;
He, Yiping;
Kumar, Deepak

Publication type:

Article