Title: Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse.
Authors: Chelu, Mihail G.; Goonasekera, Sanjeewa A.; Durham, William J.; Wei Tang; Lueck, John D.; Riehl, Joyce; Pessah, Isaac N.; Pumin Zhang; Bhattacharjee, Meenakshi B.; Dirksen, Robert T.; Hamilton, Susan L.
Abstract: Presents a study that created mice harboring mutation of tyrosine 522 of RyR1 to determine its effects on calcium homeostasis, skeletal muscle function and in vivo sensitivity to anesthesia and heat. Heterozygous Y522S mice as a model for human malignant hyperthermia; Susceptibility of heterozygous Y522S mice to heat-induced whoe body contractures in vivo and heat-induced contractures in vitro; Effects of the heterozygous mutation.
Subjects: MICE; TYROSINE; GENETIC mutation; HOMEOSTASIS; CALCIUM; PHYSIOLOGICAL control systems; MALIGNANT hyperthermia
Publication: FASEB Journal, 2006, Vol 20, Issue 2, p329
ISSN: 0892-6638
Publication type: Academic Journal
DOI: 10.1096/fj.05-4497fje

Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse.

Chelu, Mihail G.; Goonasekera, Sanjeewa A.; Durham, William J.; Wei Tang; Lueck, John D.; Riehl, Joyce; Pessah, Isaac N.; Pumin Zhang; Bhattacharjee, Meenakshi B.; Dirksen, Robert T.; Hamilton, Susan L.