Works matching Ampakines

Results: 92

Low-Impact Ampakine CX1739 Exerts Pro-Cognitive Effects and Reverses Opiate-Induced Respiratory Depression in Rodents.

Published in:

Future Pharmacology, 2024, v. 4, n. 1, p. 173, doi. 10.3390/futurepharmacol4010012

By:

Radin, Daniel Pierce;
Zhong, Sheng;
Cerne, Rok;
Shoaib, Mohammed;
Witkin, Jeffrey M.;
Lippa, Arnold

Publication type:

Article

Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep.

Published in:

Journal of Psychopharmacology, 2012, v. 26, n. 8, p. 1047, doi. 10.1177/0269881111405353

By:

Boyle, Julia;
Stanley, Neil;
James, Lynette M;
Wright, Nicola;
Johnsen, Sigurd;
Arbon, Emma L;
Dijk, Derk-Jan

Publication type:

Article

Chronic Ampakine Treatments Stimulate Dendritic Growth and Promote Learning in Middle-Aged Rats.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 5, p. 1636, doi. 10.1523/JNEUROSCI.3157-15.2016

By:

Lauterborn, Julie C.;
Palmer, Linda C.;
Jia, Yousheng;
Pham, Danielle T.;
Bowen Hou;
Weisheng Wang;
Trieu, Brian H.;
Cox, Conor D.;
Kantorovich, Svetlana;
Gall, Christine M.;
Lynch, Gary

Publication type:

Article

Poster 369: Ampakine Treatment Enhances Neurite Outgrowth.

Published in:

2010

By:

Lin, Vernon W.;
Gall, Christine M.;
Lin, Ching‐Yi

Publication type:

Abstract

Poster 329: Ampakines Enhancement of Axonal Outgrowth by Cortical Neurons.

Published in:

2009

By:

Lin, Vernon W.;
Gall, Christine M.;
Lin, Ching‐Yi

Publication type:

Abstract

High Impact AMPAkines Induce a Gq‐Protein Coupled Endoplasmic Calcium Release in Cortical Neurons: A Possible Mechanism for Explaining the Toxicity of High Impact AMPAkines.

Published in:

Synapse, 2024, v. 78, n. 5, p. 1, doi. 10.1002/syn.22310

By:

Radin, Daniel P.;
Zhong, Sheng;
Cerne, Rok;
Witkin, Jeffrey M.;
Lippa, Arnold

Publication type:

Article

Ampakines: Selective AMPA Receptor Modulators with Potential Benefits.

Published in:

Journal of Marmara University Institute of Health Sciences, 2012, v. 2, n. 4, p. 143, doi. 10.5455/musbed.20121231010422

By:

Gümrü, Salih;
Arıcıoğlu, Feyza

Publication type:

Article

AMPAkines have site-specific analgesic effects in the cortex.

Published in:

Molecular Pain, 2024, p. 1, doi. 10.1177/17448069231214677

By:

Zhu, Elaine;
Mathew, Dave;
Jee, Hyun Jung;
Sun, Mengqi;
Liu, Weizhuo;
Zhang, Qiaosheng;
Wang, Jing

Publication type:

Article

A Placebo-Controlled Add-On Trial of the Ampakine, CX516, for Cognitive Deficits in Schizophrenia.

Published in:

Neuropsychopharmacology, 2008, v. 33, n. 3, p. 465, doi. 10.1038/sj.npp.1301444

By:

Goff, Donald C.;
Lamberti, J Steven;
Leon, Andrew C.;
Green, Michael F.;
Miller, Alexander L.;
Patel, Jayendra;
Manschreck, Theo;
Freudenreich, Oliver;
Johnson, Steven A.

Publication type:

Article

Acute Effects of the Ampakine Farampator on Memory and Information Processing in Healthy Elderly Volunteers.

Published in:

Neuropsychopharmacology, 2007, v. 32, n. 6, p. 1272, doi. 10.1038/sj.npp.1301257

By:

Wezenberg, Elke;
Jan Verkes, Robert;
Ruigt, Ge S F;
Hulstijn, Wouter;
Sabbe, Bernard G C

Publication type:

Article

High-Impact AMPAkines Elevate Calcium Levels in Cortical Astrocytes by Mobilizing Endoplasmic Reticular Calcium Stores.

Published in:

Neuroglia, 2024, v. 5, n. 3, p. 344, doi. 10.3390/neuroglia5030023

By:

Radin, Daniel P.;
Cerne, Rok;
Witkin, Jeffrey;
Lippa, Arnold

Publication type:

Article

Safety, Tolerability, and Pharmacokinetic Profile of the Low‐Impact Ampakine CX1739 in Young Healthy Volunteers.

Published in:

Clinical Pharmacology in Drug Development, 2025, v. 14, n. 1, p. 50, doi. 10.1002/cpdd.1475

By:

Radin, Daniel P.;
Cerne, Rok;
Witkin, Jeffrey M.;
Lippa, Arnold

Publication type:

Article

AMPAkines potentiate the corticostriatal pathway to reduce acute and chronic pain.

Published in:

Molecular Brain, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13041-021-00757-y

By:

Zeng, Fei;
Zhang, Qiaosheng;
Liu, Yaling;
Sun, Guanghao;
Li, Anna;
Talay, Robert S.;
Wang, Jing

Publication type:

Article

Design, Synthesis and Biological Evaluation of Brain-Targeted Thiamine Disulfide Prodrugs of Ampakine Compound LCX001.

Published in:

Molecules, 2016, v. 21, n. 4, p. 488, doi. 10.3390/molecules21040488

By:

Dian Xiao;
Fan-Hua Meng;
Wei Dai;
Zheng Yong;
Jin-Qiu Liu;
Xin-Bo Zhou;
Song Li

Publication type:

Article

Preclinical Pharmacology of the Low-Impact Ampakine CX717.

Published in:

Future Pharmacology, 2024, v. 4, n. 3, p. 494, doi. 10.3390/futurepharmacol4030028

By:

Radin, Daniel P.;
Zhong, Sheng;
Cerne, Rok;
Smith, Jodi L.;
Witkin, Jeffrey M.;
Lippa, Arnold

Publication type:

Article

Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and Chemical Reaction With Tissue Fixative Agents.

Published in:

Toxicological Sciences, 2018, v. 162, n. 2, p. 383, doi. 10.1093/toxsci/kfx277

By:

Purcell, Richard;
Lynch, Gary;
Gall, Christine;
Johnson, Steven;
Sheng, Zhong;
Stephen, Michael Rajesh;
Cook, James;
Garman, Robert H;
Jortner, Bernard;
Bolon, Brad

Publication type:

Article

Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia—sub-chronic and early postnatal PCP treatment in attentional set-shifting.

Published in:

Psychopharmacology, 2009, v. 206, n. 4, p. 631, doi. 10.1007/s00213-009-1540-5

By:

Broberg, Brian Villumsen;
Glenthøj, Birte Yding;
Dias, Rebecca;
Larsen, Dorrit Bjerg;
Olsen, Christina Kurre

Publication type:

Article

Fármacos glutamatérgicos en tratamiento de la esquizofrenia.

Published in:

Actas Espanolas de Psiquiatria, 2014, v. 42, n. 5, p. 234

By:

Gibert-Rahola, Juan;
Villena-Rodriguez, Abigail

Publication type:

Article

Stimulation of Respiratory Motor Output and Ventilation in a Murine Model of Pompe Disease by Ampakines.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2015, v. 53, n. 3, p. 326, doi. 10.1165/rcmb.2014-0374OC

By:

ElMallah, Mai K.;
Pagliardini, Silvia;
Turner, Sara M.;
Cerreta, Anthony J.;
Falk, Darin J.;
Byrne, Barry J.;
Greer, John J.;
Fuller, David D.

Publication type:

Article

Ampakines: Selective AMPA Receptor Modulators with Potential Benefits.

Published in:

2012

By:

Gümrü, Salih;
Arıcıoğlu, Feyza

Publication type:

Journal Article

Opiate-Induced Suppression of Rat Hypoglossal Motoneuron Activity and Its Reversal by Ampakine Therapy.

Published in:

PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008766

By:

Lorier, Amanda R.;
Funk, Gregory D.;
Greer, John J.

Publication type:

Article

Ampakines induce a persistent increase in phrenic motor output in rats with cervical spinal cord injury.

Published in:

FASEB Journal, 2013, v. 27, p. 930.9, doi. 10.1096/fasebj.27.1_supplement.930.9

By:

Sandhu, Milap Singh;
Elmallah, Mai K;
Lane, Michael A;
Reier, Paul J;
Greer, John J;
Fuller, David D

Publication type:

Article

Ampakines alleviate respiratory depression in rats.

Published in:

FASEB Journal, 2007, v. 21, n. 5, p. A558

By:

Greer, John James;
Ren, Jun;
Poon, Betty;
Funk, Greg D.

Publication type:

Article

Ampakines alleviate respiratory depression in rats.

Published in:

2006

By:

Ren J;
Poon BY;
Tang Y;
Funk GD;
Greer JJ

Publication type:

Journal Article

Facilitation of Task Performance and Removal of the Effects of Sleep Deprivation by an Ampakine (CX717) in Nonhuman Primates.

Published in:

PLoS Biology, 2005, v. 3, n. 9, p. 1639, doi. 10.1371/journal.pbio.0030299

By:

Porrino, Linda J.;
Daunais, James B.;
Rogers, Gary A.;
Hampson, Robert E.;
Deadwyler, Sam A.

Publication type:

Article

Facilitation of Task Performance and Removal of the Effects of Sleep Deprivation by an Ampakine (CX717) in Nonhuman Primates.

Published in:

PLoS Biology, 2005, v. 3, n. 8, p. 1, doi. 10.1371/journal.pbio.0030299

By:

Porrino, Linda J;
Daunais, James B;
Rogers, Gary A;
Hampson, Robert E;
Deadwyler, Sam A

Publication type:

Article

Selective Antagonism of Opioid-Induced Ventilatory Depression by an Ampakine Molecule in Humans Without Loss of Opioid Analgesia.

Published in:

Clinical Pharmacology & Therapeutics, 2010, v. 87, n. 2, p. 204, doi. 10.1038/clpt.2009.194

By:

Oertel, B. G.;
Felden, L.;
Tran, P. V.;
Bradshaw, M. H.;
Angst, M. S.;
Schmidt, H.;
Johnson, S.;
Greer, J. J.;
Geisslinger, G.;
Varney, M. A.;
Lötsch, J.

Publication type:

Article

EFFECTS OF THE AMPAKINE CX516 ON MEMORY.

Published in:: 2000
Publication type:: Abstract

Acute ampakines increase voiding function and coordination in a rat model of SCI.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.89767

By:

Rana, Sabhya;
Alom, Firoj;
Martinez, Robert C.;
Fuller, David D.;
Mickle, Aaron D.

Publication type:

Article

Brain-Derived Neurotrophic Factor Expression and Respiratory Function Improve after Ampakine Treatment in a Mouse Model of Rett Syndrome.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 40, p. 10912, doi. 10.1523/JNEUROSCI.1869-07.2007

By:

Ogier, Michael;
Hong Wang;
Hong, Elizabeth;
Qifang Wang;
Greenberg, Michael E.;
Katz, David M.

Publication type:

Article

Combined ampakine and BDNF treatments enhance poststroke functional recovery in aged mice via AKT-CREB signaling.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2015, v. 35, n. 8, p. 1272, doi. 10.1038/jcbfm.2015.33

By:

Clarkson, Andrew N;
Parker, Kim;
Nilsson, Michael;
Walker, F Rohan;
Gowing, Emma K

Publication type:

Article

Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity.

Published in:

Molecular Autism, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13229-019-0265-5

By:

Tatsukawa, Tetsuya;
Raveau, Matthieu;
Ogiwara, Ikuo;
Hattori, Satoko;
Miyamoto, Hiroyuki;
Mazaki, Emi;
Itohara, Shigeyoshi;
Miyakawa, Tsuyoshi;
Montal, Mauricio;
Yamakawa, Kazuhiro

Publication type:

Article

Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717.

Published in:

Psychopharmacology, 2009, v. 202, n. 1-3, p. 355, doi. 10.1007/s00213-008-1360-z

By:

Hampson, R.;
España, R.;
Rogers, G.;
Porrino, L.;
Deadwyler, S.

Publication type:

Article

Cortex receives US patent for the use of ampakine molecules to treat respiratory depression.

Published in:: Journal of Intellectual Property Rights, 2011, v. 16, n. 5, p. 442
Publication type:: Article

Cognitive enhancement in children and adolescents: Is it in their best interests?

Published in:

Acta Paediatrica, 2013, v. 102, n. 12, p. 1118, doi. 10.1111/apa.12409

By:

Gaucher, N;
Payot, A;
Racine, E

Publication type:

Article

Neuro-Enhancement.

Published in:

Der Nervenarzt, 2009, v. 80, n. 7, p. 840, doi. 10.1007/s00115-009-2801-6

By:

Förstl, H.

Publication type:

Article

The Pattern of Ampakine and Hypoxia Exposure Determines Phrenic Motor Facilitation.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R3887

By:

Thakre, Prajwal P.;
Sunshine, Michael D.;
Fuller, David D.

Publication type:

Article

Ampakine CX717 Stimulates Diaphragm Activity following Mid‐cervical Spinal Contusion Injury.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.0R711

By:

Rana, Sabhya;
Thakre, Prajwal;
Barral, Brian;
Fuller, David

Publication type:

Article

Ampakine‐Hypoxia Induced Phrenic Motor Facilitation is Not Prevented by Intrathecal Methysergide.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R4604

By:

Thakre, Prajwal P.;
Sunshine, Michael D.;
Fuller, David D.

Publication type:

Article

Ampakines enhance phrenic nerve output in a ZFN rat model of Pompe Disease.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.01990

By:

Jensen, Victoria;
Sunshine, Michael;
Byrne, Barry;
Fuller, David

Publication type:

Article

Low Dose Ampakine Stimulates Diaphragm Activity and Increases Tidal Volume following Cervical Spinal Cord Injury in Non‐Anesthetized Freely Behaving Rats.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.01513

By:

Rana, Sabhya;
Sunshine, Michael;
Fuller, David

Publication type:

Article

Ampakine Pretreatment Enables One Episode of Hypoxia to Produce Phrenic Motor Facilitation with No Added Benefit of Additional Hypoxic Episodes.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02847

By:

Thakre, Prajwal;
Sunshine, Michael;
Fuller, David

Publication type:

Article

Ampakines Enhance Weak Endogenous Respiratory Drive and Alleviate Apnea in Perinatal Rats.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2015, v. 191, n. 6, p. 704, doi. 10.1164/rccm.201410-1898OC

By:

Ren, Jun;
Xiuqing Ding;
Greer, John J.

Publication type:

Article

Antidepressant, Psychostimulant, and Nootropic Effects of Major and Trace Element Composition.

Published in:

Bulletin of Experimental Biology & Medicine, 2013, v. 155, n. 2, p. 204, doi. 10.1007/s10517-013-2113-5

By:

Afanasieva, O.;
Suslov, N.;
Shilova, I.

Publication type:

Article

MICRODIALYSIS STUDIES IN THE FRONTAL CORTEX OF THE FREELY MOVING RAT TO INVESTIGATE THE INTERACTION BETWEEN THE NOVEL AMPAKINE CX 516 AND SEROTONERGIC NEUROTRANSMISSION.

Published in:: British Journal of Pharmacology, 2002, v. 137, p. 73
Publication type:: Article

P2-440: A memory enhancing drug ampakine (CX-717) potentially modulates synaptic AMPA receptor channel properties

Published in:

2008

By:

Kariharan, Thiruchelvam;
Shonesy, Brian C.;
Parameshwaran, Koodeswaran;
Suppiramaniam, Vishnu D.

Publication type:

Abstract

Ampakines Alleviate Respiratory Depression in Rats.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2006, v. 174, n. 12, p. 1384, doi. 10.1164/rccm.200606-778OC

By:

Ren, Jun;
Poon, Betty Y.;
Yun Tang;
Funk, Gregory D.;
Greer, John J.

Publication type:

Article

Randomized, double-blind, placebo-controlled international clinical trial of the Ampakine® CX516 in elderly participants with mild cognitive impairment.

Published in:

Journal of Molecular Neuroscience, 2002, v. 19, n. 1/2, p. 197, doi. 10.1007/s12031-002-0032-4

By:

Johnson, Steven;
Simmon, Vincent

Publication type:

Article

The Ampakine CX546 Restores the Prepulse Inhibition and Latent Inhibition Deficits in mGluR5-Deficient Mice.

Published in:

Neuropsychopharmacology, 2007, v. 32, n. 4, p. 745, doi. 10.1038/sj.npp.1301191

By:

Lipina, Tatiana;
Weiss, Karin;
Roder, John

Publication type:

Article

Ampakine™ CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting asα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators.

Published in:

Journal of Neurochemistry, 2005, v. 92, n. 3, p. 668, doi. 10.1111/j.1471-4159.2004.02905.x

By:

Pellerin, Luc;
Magistretti, Pierre J.

Publication type:

Article