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- Title
Maternal Immunization with Pneumococcal Polysaccharide Vaccine: Persistence of Maternal Antibodies in Infants.
- Authors
Berezin, Eitan N.; Lopes, Claudia C.; Cardoso, Maria Regina A.
- Abstract
Objective: To evaluate the level and the persistence of maternal antibodies in infants after maternal immunization with pneumococcal polysaccharide vaccine (Pn23V).Methods: Pregnant women were assigned to two groups, during routine low-risk pre-natal visits. The first Group (VAC) received the Pn23V vaccine shortly after enrolment at 28 weeks or later, and the second Group (NO_VAC) received no vaccine. To investigate the antibody persistence, we collected blood samples from the mothers after 1 month of delivery and from the infants at 1 and 6 months of age.Results: Antibody titers were measured for serotypes 1, 6B and 14. Geometric mean antibody concentrations of specific immunoglobulin G were significantly higher in the vaccinated group compared with unvaccinated controls for all three serotypes tested.Conclusion: Despite the antibody level's decline, at 6 months of age, proportions >0.35 μg/ml remained higher in the infants of vaccinated mothers than controls for all three serotypes.
- Subjects
IMMUNIZATION; PNEUMOCOCCAL vaccines; IMMUNOGLOBULINS; INFANTS; PREGNANT women; STREPTOCOCCAL disease prevention; COMPARATIVE studies; MATERNALLY acquired immunity; RESEARCH methodology; MEDICAL cooperation; RESEARCH; STREPTOCOCCAL diseases; TIME; EVALUATION research; SEROTYPING; BACTERIAL antibodies
- Publication
Journal of Tropical Pediatrics, 2017, Vol 63, Issue 2, p118
- ISSN
0142-6338
- Publication type
Academic Journal
- DOI
10.1093/tropej/fmw060