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- Title
Is Hyperuricemia Overlooked when Treating Pediatric Tuberculosis Patients with Pyrazinamide?
- Authors
Şişmanlar, Tuğba; Aslan, Ayşe T.; Budakoğlu, Irem
- Abstract
The treatment of tuberculosis (TB) requires long-term multiple drug use. Hyperuricemia is frequently reported in adults, but there are few data for the pediatric population. This study aimed to review drug-related side effects in pediatric patients that received treatment for TB. Patients with active TB undergoing treatment were followed for drug-related side effects. During the 7 year period, 23 patients with a mean age of 7.9 ± 4.66 years were treated. Drug-related side effects were observed in 14 patients. Hyperuricemia occurred in 12 of the 14 patients, vs. hepatotoxicity in 2. In all, eight of the patients with hyperuricemia had ≥2 episodes during pyrazinamide (PZA) therapy. Based on these findings, we devised an algorithm that could be used for the management of hyperuricemia in patients receiving PZA because of TB, and recommend that hyperuricemia be closely monitored during PZA therapy.
- Subjects
DRUG therapy for tuberculosis; ALLOPURINOL; ANTITUBERCULAR agents; DRUG administration; DRUG side effects; HYPERURICEMIA; MYCOBACTERIUM tuberculosis; URIC acid; TREATMENT effectiveness; RETROSPECTIVE studies; PYRAZINAMIDE; THERAPEUTICS
- Publication
Journal of Tropical Pediatrics, 2015, Vol 61, Issue 5, p351
- ISSN
0142-6338
- Publication type
Academic Journal
- DOI
10.1093/tropej/fmv042