Development of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis: a case report from KwaZulu-Natal, South Africa.

Murphy, Richard A.; France, Holly; Sunpath, Henry; Gordon, Michelle L.; Marconi, Vincent C.; Kuritzkes, Daniel R.; McIntosh, Kenneth

The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug–drug interactions. The recommended antiretroviral therapy (ART) in coinfected children in South Africa consists of full-strength ritonavir, lamivudine and stavudine. We report on a child initiated on this regimen, during concurrent TB treatment, who promptly developed an adverse reaction, virologic failure and dual-class antiretroviral drug resistance, compromising subsequent salvage ART.

SOUTH Africa; HIV infections; TUBERCULOSIS in children; DRUG interactions; ANTIRETROVIRAL agents; DRUG resistance; DRUG therapy for tuberculosis; TUBERCULOSIS complications; ANTITUBERCULAR agents; HIV infection complications; COMBINATION drug therapy; DRUG resistance in microorganisms; HIV; RNA; TUBERCULOSIS; HIGHLY active antiretroviral therapy; TREATMENT effectiveness; ANTI-HIV agents; PHARMACODYNAMICS

Journal of Tropical Pediatrics, 2009, Vol 55, Issue 1, p60

0142-6338

Academic Journal

10.1093/tropej/fmn074