Works matching IS 10966080 AND DT 2019 AND VI 167 AND IP 2

Results: 27

Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 385, doi. 10.1093/toxsci/kfy244

By:

Giustarini, Giulio;
Vrisekoop, Nienke;
Kruijssen, Laura;
Wagenaar, Laura;
Staveren, Selma van;
Roest, Manon van;
Bleumink, Rob;
Bol-Schoenmakers, Marianne;
Weaver, Richard J;
Koenderman, Leo;
Smit, Joost;
Pieters, Raymond

Publication type:

Article

Today's Challenges to De-Risk and Predict Drug Safety in Human "Mind-the-Gap".

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 307, doi. 10.1093/toxsci/kfy270

By:

Weaver, Richard J;
Valentin, Jean-Pierre

Publication type:

Article

Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 360, doi. 10.1093/toxsci/kfy239

By:

Huo, Jianhua;
Wei, Feng;
Cai, Chengzhong;
Lyn-Cook, Beverly;
Pang, Li

Publication type:

Article

Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on In Vitro Cardiac Safety Evaluation.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 573, doi. 10.1093/toxsci/kfy264

By:

Zeng, Haoyu;
Wang, Jixin;
Clouse, Holly;
Lagrutta, Armando;
Sannajust, Frederick

Publication type:

Article

Rationalizing Secondary Pharmacology Screening Using Human Genetic and Pharmacological Evidence.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 593, doi. 10.1093/toxsci/kfy265

By:

Deaton, Aimee M;
Fan, Fan;
Zhang, Wei;
Nguyen, Phuong A;
Ward, Lucas D;
Nioi, Paul

Publication type:

Article

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 458, doi. 10.1093/toxsci/kfy253

By:

Longo, Diane M;
Woodhead, Jeffrey L;
Walker, Paul;
Herédi-Szabó, Krisztina;
Mogyorósi, Károly;
Wolenski, Francis S;
Dragan, Yvonne P;
Mosedale, Merrie;
Siler, Scott Q;
Watkins, Paul B;
Howell, Brett A

Publication type:

Article

Proteomic and Metabolomic Profiling Identify Plasma Biomarkers for Exposure to Ultra-low Levels of Carfentanil.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 524, doi. 10.1093/toxsci/kfy259

By:

Dhummakupt, Elizabeth S;
Rizzo, Gabrielle M;
Feasel, Michael;
Mach, Phillip M;
Tran, Bao Q;
Carmany, Daniel O;
Demond, Paul S;
McBride, Ethan M;
Maughan, Michele;
Sekowski, Jennifer W;
Glaros, Trevor

Publication type:

Article

Prenatal Bisphenol A Exposure Alters Epithelial Cell Composition in the Rhesus Macaque Fetal Oviduct.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 450, doi. 10.1093/toxsci/kfy251

By:

Hung, Pei-Hsuan;
Winkle, Laura S Van;
Williams, Carmen J;
Hunt, Patricia A;
VandeVoort, Catherine A

Publication type:

Article

Prediction of Acute Oral Systemic Toxicity Using a Multifingerprint Similarity Approach.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 484, doi. 10.1093/toxsci/kfy255

By:

Alberga, Domenico;
Trisciuzzi, Daniela;
Mansouri, Kamel;
Mangiatordi, Giuseppe Felice;
Nicolotti, Orazio

Publication type:

Article

Oxygen and Arsenite Synergize Phosphine Toxicity by Distinct Mechanisms.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 419, doi. 10.1093/toxsci/kfy248

By:

Alzahrani, Saad M;
Ebert, Paul R

Publication type:

Article

Nicotine Promotes Human Papillomavirus (HPV)-Immortalized Cervical Epithelial Cells (H8) Proliferation by Activating RPS27a-Mdm2-P53 Pathway In Vitro.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 408, doi. 10.1093/toxsci/kfy246

By:

Chen, Lu;
Wang, Huai

Publication type:

Article

linc00152 Controls Cell Cycle Progression by Regulating CCND1 in 16HBE Cells Malignantly Transformed by Cigarette Smoke Extract.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 496, doi. 10.1093/toxsci/kfy254

By:

Liu, Zhenzhong;
Liu, Anfei;
Nan, Aruo;
Cheng, Ying;
Yang, Ti;
Dai, Xin;
Chen, Lijian;
Li, Xin;
Jia, Yangyang;
Zhang, Nan;
Jiang, Yiguo

Publication type:

Article

Impact of Scaling Factor Variability on Risk-Relevant Pharmacokinetic Outcomes in Children: A Case Study Using Bromodichloromethane (BDCM).

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 347, doi. 10.1093/toxsci/kfy236

By:

Kenyon, Elaina M;
Lipscomb, John C;
Pegram, Rex A;
George, Barbara J;
Hines, Ronald N

Publication type:

Article

Host Developmental Toxicity of BPA and BPA Alternatives Is Inversely Related to Microbiota Disruption in Zebrafish.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 468, doi. 10.1093/toxsci/kfy261

By:

Catron, Tara R;
Keely, Scott P;
Brinkman, Nichole E;
Zurlinden, Todd J;
Wood, Charles E;
Wright, Justin R;
Phelps, Drake;
Wheaton, Emily;
Kvasnicka, Allison;
Gaballah, Shaza;
Lamendella, Regina;
Tal, Tamara

Publication type:

Article

From the Editor's Desk, Editor's Highlights.

Published in:: Toxicological Sciences, 2019, v. 167, n. 2, p. 305, doi. 10.1093/toxsci/kfz018
Publication type:: Article

Framework for Systematic Evaluation and Quantitative Integration of Mechanistic Data in Assessments of Potential Human Carcinogens.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 322, doi. 10.1093/toxsci/kfy279

By:

Wikoff, Daniele S;
Rager, Julia E;
Chappell, Grace A;
Fitch, Seneca;
Haws, Laurie;
Borghoff, Susan J

Publication type:

Article

Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 375, doi. 10.1093/toxsci/kfy245

By:

Dent, Matthew P;
Li, Hequn;
Carmichael, Paul L;
Martin, Francis L

Publication type:

Article

Differential Toxicity of Alkylphenols in JEG-3 Human Placental Cells: Alteration of P450 Aromatase and Cell Lipid Composition.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 336, doi. 10.1093/toxsci/kfy243

By:

Pérez-Albaladejo, Elisabet;
Lacorte, Silvia;
Porte, Cinta

Publication type:

Article

Dichloroacetate Ameliorates Cardiac Dysfunction Caused by Ischemic Insults Through AMPK Signal Pathway—Not Only Shifts Metabolism.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 604, doi. 10.1093/toxsci/kfy272

By:

Li, Xuan;
Liu, Jia;
Hu, Haiyan;
Lu, Shaoxin;
Lu, Qingguo;
Quan, Nanhu;
Rousselle, Thomas;
Patel, Mulchand S;
Li, Ji

Publication type:

Article

Developmental Regulation of Nuclear Factor Erythroid-2 Related Factors (nrfs) by AHR1b in Zebrafish (Danio rerio).

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 536, doi. 10.1093/toxsci/kfy257

By:

Ulin, Alexandra;
Henderson, Jake;
Pham, Minh-Tam;
Meyo, James;
Chen, Yuying;
Karchner, Sibel I;
Goldstone, Jared V;
Hahn, Mark E;
Williams, Larissa M

Publication type:

Article

Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 581, doi. 10.1093/toxsci/kfy263

By:

Lu, Peipei;
Cai, Xinran;
Guo, Yan;
Xu, Meishu;
Tian, Jianmin;
Locker, Joseph;
Xie, Wen

Publication type:

Article

Comparison of Chlorantraniliprole and Flubendiamide Activity Toward Wild-Type and Malignant Hyperthermia-Susceptible Ryanodine Receptors and Heat Stress Intolerance.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 509, doi. 10.1093/toxsci/kfy256

By:

Truong, Kim M;
Pessah, Isaac N

Publication type:

Article

Benzene Exposure Induces Insulin Resistance in Mice.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 426, doi. 10.1093/toxsci/kfy252

By:

Abplanalp, Wesley T;
Wickramasinghe, Nalinie S;
Sithu, Srinivas D;
Conklin, Daniel J;
Xie, Zhengzhi;
Bhatnagar, Aruni;
Srivastava, Sanjay;
O'Toole, Timothy E

Publication type:

Article

Automated Morphological Feature Assessment for Zebrafish Embryo Developmental Toxicity Screens.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 438, doi. 10.1093/toxsci/kfy250

By:

Teixidó, Elisabet;
Kießling, Tobias R;
Krupp, Eckart;
Quevedo, Celia;
Muriana, Arantza;
Scholz, Stefan

Publication type:

Article

Ambient Particulate Matter and Acrolein Co-Exposure Increases Myocardial Dyssynchrony in Mice via TRPA1.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 559, doi. 10.1093/toxsci/kfy262

By:

Thompson, Leslie C;
Walsh, Leon;
Martin, Brandi L;
McGee, John;
Wood, Charles;
Kovalcik, Kasey;
Pancras, Joseph Patrick;
Haykal-Coates, Najwa;
Ledbetter, Allen D;
Davies, David;
Cascio, Wayne E;
Higuchi, Mark;
Hazari, Mehdi S;
Farraj, Aimen K

Publication type:

Article

Allyl Sulfide Counteracts 1-Bromopropane-Induced Neurotoxicity by Inhibiting Neuroinflammation and Oxidative Stress.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 397, doi. 10.1093/toxsci/kfy240

By:

Suo, Jinning;
Zhang, Cuili;
Wang, Pin;
Hou, Liyan;
Wang, Qingshan;
Zhao, Xiulan

Publication type:

Article

All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and Testicular Cell Fate.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 546, doi. 10.1093/toxsci/kfy260

By:

Spade, Daniel J;
Dere, Edward;
Hall, Susan J;
Schorl, Christoph;
Freiman, Richard N;
Boekelheide, Kim

Publication type:

Article