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Application of Microphysiological Systems for Nonclinical Evaluation of Cell Therapies.
Published in:
Altex, 2024, v. 41, n. 3, p. 469, doi. 10.14573/altex.2402201
By:
- Candarlioglu, Pelin L.;
- Delsing, Louise;
- Gauthier, Lauren;
- Lewis, Lauren;
- Papadopoulos, George;
- Freag, May;
- Chan, Tom S.;
- Homan, Kimberly A.;
- Fellows, Mick D.;
- Pointon, Amy;
- Kolaja, Kyle
Publication type:
Article
An Extensive Metabolomics Workflow to Discover Cardiotoxin-Induced Molecular Perturbations in Microtissues.
Published in:
Metabolites (2218-1989), 2021, v. 11, n. 9, p. 644, doi. 10.3390/metabo11090644
By:
- Bowen, Tara J.;
- Hall, Andrew R.;
- Lloyd, Gavin R.;
- Weber, Ralf J. M.;
- Wilson, Amanda;
- Pointon, Amy;
- Viant, Mark R.
Publication type:
Article
Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40333-7
By:
- Bowen, Tara J.;
- Southam, Andrew D.;
- Hall, Andrew R.;
- Weber, Ralf J. M.;
- Lloyd, Gavin R.;
- Macdonald, Ruth;
- Wilson, Amanda;
- Pointon, Amy;
- Viant, Mark R.
Publication type:
Article
Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation.
Published in:
PLoS ONE, 2010, v. 5, n. 9, p. 1, doi. 10.1371/journal.pone.0012733
By:
- Pointon, Amy V.;
- Walker, Tracy M.;
- Phillips, Kate M.;
- Luo, Jinli;
- Riley, Joan;
- Shu-Dong Zhang;
- Parry, Joel D.;
- Lyon, Jonathan J.;
- Marczylo, Emma L.;
- Gant, Timothy W.
Publication type:
Article
On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-45656-4
By:
- McAleer, Christopher W.;
- Pointon, Amy;
- Long, Christopher J.;
- Brighton, Rocky L.;
- Wilkin, Benjamin D.;
- Bridges, L. Richard;
- Narasimhan Sriram, Narasimham;
- Fabre, Kristin;
- McDougall, Robin;
- Muse, Victorine P.;
- Mettetal, Jerome T.;
- Srivastava, Abhishek;
- Williams, Dominic;
- Schnepper, Mark T.;
- Roles, Jeff L.;
- Shuler, Michael L.;
- Hickman, James J.;
- Ewart, Lorna
Publication type:
Article
Anticancer drugs and cardiotoxicity: the role of cardiomyocyte and non-cardiomyocyte cells.
Published in:
Frontiers in Cardiovascular Medicine, 2024, p. 1, doi. 10.3389/fcvm.2024.1372817
By:
- Koukorava, Chrysa;
- Ahmed, Katie;
- Almaghrabi, Shrouq;
- Pointon, Amy;
- Haddrick, Malcolm;
- Cross, Michael J.
Publication type:
Article
RYR2 deficient human model identifies calcium handling and metabolic dysfunction impacting pharmacological responses.
Published in:
Frontiers in Cardiovascular Medicine, 2024, p. 1, doi. 10.3389/fcvm.2024.1357315
By:
- Starnes, Linda;
- Hall, Andrew;
- Etal, Damla;
- Cavallo, Anna-Lina;
- Grabowski, Piotr;
- Gallon, John;
- Kha, Michelle;
- Hicks, Ryan;
- Pointon, Amy
Publication type:
Article
Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency.
Published in:
PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0214545
By:
- Schindler, Christina;
- Collinson, Andie;
- Matthews, Carl;
- Pointon, Amy;
- Jenkinson, Lesley;
- Minter, Ralph R.;
- Vaughan, Tristan J.;
- Tigue, Natalie J.
Publication type:
Article
Computational approaches identify a transcriptomic fingerprint of drug-induced structural cardiotoxicity.
Published in:
Cell Biology & Toxicology, 2024, v. 40, n. 1, p. 1, doi. 10.1007/s10565-024-09880-7
By:
- Au Yeung, Victoria P.W.;
- Obrezanova, Olga;
- Zhou, Jiarui;
- Yang, Hongbin;
- Bowen, Tara J.;
- Ivanov, Delyan;
- Saffadi, Izzy;
- Carter, Alfie S.;
- Subramanian, Vigneshwari;
- Dillmann, Inken;
- Hall, Andrew;
- Corrigan, Adam;
- Viant, Mark R.;
- Pointon, Amy
Publication type:
Article
High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery.
Published in:
Toxicological Sciences, 2017, v. 155, n. 2, p. 444, doi. 10.1093/toxsci/kfw227
By:
- Pointon, Amy;
- Pilling, James;
- Dorval, Thierry;
- Yinhai Wang;
- Archer, Caroline;
- Pollard, Christopher
Publication type:
Article
Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues.
Published in:
Toxicological Sciences, 2016, v. 152, n. 1, p. 99, doi. 10.1093/toxsci/kfw069
By:
- Ravenscroft, Stephanie M.;
- Pointon, Amy;
- Williams, Awel W.;
- Cross, Michael J.;
- Sidaway, James E.
Publication type:
Article
Enhanced Characterization of Contractility in Cardiomyocytes During Early Drug Safety Assessment.
Published in:
Toxicological Sciences, 2015, v. 145, n. 2, p. 396, doi. 10.1093/toxsci/kfv062
By:
- Butler, Larissa;
- Cros, Caroline;
- Oldman, Karen L.;
- Harmer, Alex R.;
- Pointon, Amy;
- Pollard, Christopher E.;
- Abi-Gerges, Najah
Publication type:
Article
Assessment of Cardiomyocyte Contraction in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Published in:
Toxicological Sciences, 2015, v. 144, n. 2, p. 227, doi. 10.1093/toxsci/kfu312
By:
- Pointon, Amy;
- Harmer, Alexander R.;
- Dale, Ian L.;
- Abi-Gerges, Najah;
- Bowes, Joanne;
- Pollard, Christopher;
- Garside, Helen
Publication type:
Article
Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity.
Published in:
Toxicological Sciences, 2013, v. 132, n. 2, p. 317, doi. 10.1093/toxsci/kft005
By:
- Pointon, Amy;
- Abi-Gerges, Najah;
- Cross, Michael J.;
- Sidaway, James E.
Publication type:
Article

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