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- Title
Protective effects of quercetin against tongue injury and oxidative stress triggered by irinotecan: a histopathological, biochemical and molecular study.
- Authors
Faruk, Eman Mohamed; Ibrahim, Fatma; Hassan, Mahmoud M; Kamal, Kamal M; Hassan, Dina Allam Abdelmaksoud; Awwad, Ayat Abu-elnasr; Taha, Neama Mahmoud; Hablas, Mohamed Ghazy Attia; Zaazaa, Ahmed Mohammed; Ibrahim, Mai Hassan
- Abstract
Introduction About 80% of patients receiving chemotherapeutics suffer from side effects related to the gastrointestinal tract. Irinotecan (CPT-11) is a chemotherapeutic agent usually used in treating solid tumors. Quercetin (QRT), a bioflavonoid, is an antioxidant and scavenger reactive oxygen species scavenger. Objective The current study explored the possible protective effects of QRT against mucosal tongue injury caused by CPT-11. Methods The study included four equal groups: group 1/control, group 2/QRT, group 3/CPT-11, and group 4/CPT-11 + QRT. Results CPT-11-induced tongue injury in the form of non-healed ulcers, absent lingual papillae, mononuclear cells infiltration, marked deposition of collagen fibers, and overexpression of CD86 and tumor necrosis factor- α (TNF-α). The increased malondialdehyde levels, decreased superoxide dismutase and total antioxidant capacity revealed that there was an oxidative stress. Also, there was a decreased countenance of Ki-67 and Bcl-2 and an increased countenance of NF-κB. The QRT-treated group showed complete ulcer healing, with histological features almost like the control group, along with minimal collagen fiber deposition, decreased reactivity to CD86 and TNF-α and improvement of oxidative stress status and the molecular study results as well. Conclusion QRT possess protective properties against CPT-11-triggered tongue injury.
- Subjects
FREE radical scavengers; OXIDANT status; OXIDATIVE stress; SUPEROXIDE dismutase; GASTROINTESTINAL system
- Publication
Toxicology Research, 2024, Vol 13, Issue 6, p1
- ISSN
2045-452X
- Publication type
Academic Journal
- DOI
10.1093/toxres/tfae214