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- Title
Fe–Zn alloy, a new biodegradable material capable of reducing ROS and inhibiting oxidative stress.
- Authors
Yang, Shuaikang; Wang, Weiqiang; Xu, Yanan; Yuan, Yonghui; Hao, Shengzhi
- Abstract
Fe-based biodegradable materials have attracted significant attention due to their exceptional mechanical properties and favorable biocompatibility. Currently, research on Fe-based materials mainly focuses on regulating the degradation rate. However, excessive release of Fe ions during material degradation will induce the generation of reactive oxygen species (ROS), leading to oxidative stress and ferroptosis. Therefore, the control of ROS release and the improvement of biocompatibility for Fe-based materials are very important. In this study, new Fe–Zn alloys were prepared by electrodeposition with the intention of using Zn as an antioxidant to reduce oxidative damage during alloy degradation. Initially, the impact of three potential degradation ions (Fe2 , Fe3 , Zn2 ) from the Fe–Zn alloy on human endothelial cell (EC) activity and migration ability was investigated. Subsequently, cell adhesion, cell activity, ROS production and DNA damage were assessed at various locations surrounding the alloy. Finally, the influence of different concentrations of Zn2 in the medium on cell viability and ROS production was evaluated. High levels of ROS exhibited evident toxic effects on ECs and promoted DNA damage. As an antioxidant, Zn2 effectively reduced ROS production around Fe and improved the cell viability on its surface at a concentration of 0.04 mmol/l. These findings demonstrate that Fe–Zn alloy can attenuate the ROS generated from Fe degradation thereby enhancing cytocompatibility.
- Subjects
POISONS; IRON alloys; REACTIVE oxygen species; DNA damage; OXIDATIVE stress; BIODEGRADABLE materials
- Publication
Regenerative Biomaterials, 2024, Vol 11, p1
- ISSN
2056-3418
- Publication type
Academic Journal
- DOI
10.1093/rb/rbae002