Works matching DE "WITHANOLIDES"

Results: 113

Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 32, p. 8350, doi. 10.1002/chem.202100315

By:

Bonandi, Elisa;
Mori, Mattia;
Infante, Paola;
Basili, Irene;
Di Marcotullio, Lucia;
Calcaterra, Andrea;
Catti, Federica;
Botta, Bruno;
Passarella, Daniele

Publication type:

Article

Biology-Oriented Synthesis of a Withanolide-Inspired Compound Collection Reveals Novel Modulators of Hedgehog Signaling.

Published in:

Angewandte Chemie, 2015, v. 127, n. 19, p. 5688, doi. 10.1002/ange.201500112

By:

Švenda, Jakub;
Sheremet, Michael;
Kremer, Lea;
Maier, Lukáš;
Bauer, Jonathan O.;
Strohmann, Carsten;
Ziegler, Slava;
Kumar, Kamal;
Waldmann, Herbert

Publication type:

Article

HSCCC Straightforward Fast Preparative Method for Isolation of Two Major Cytotoxic Withanolides from Athenaea fasciculata (Vell.) I.M.C. Rodrigues & Stehmann.

Published in:

Plants (2223-7747), 2024, v. 13, n. 21, p. 3039, doi. 10.3390/plants13213039

By:

Marques, André Mesquita;
Brito, Lavínia de Carvalho;
Figueiredo, Maria Raquel

Publication type:

Article

Enhancing Withanolide Production in the Withania Species: Advances in In Vitro Culture and Synthetic Biology Approaches.

Published in:

Plants (2223-7747), 2024, v. 13, n. 15, p. 2171, doi. 10.3390/plants13152171

By:

Ahmad, Zishan;
Shareen;
Ganie, Irfan Bashir;
Firdaus, Fatima;
Ramakrishnan, Muthusamy;
Shahzad, Anwar;
Ding, Yulong

Publication type:

Article

Optimization of Elicitation Conditions to Enhance the Production of Potent Metabolite Withanolide from Withania somnifera (L.).

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 9, p. 854, doi. 10.3390/metabo12090854

By:

Singh, Manali;
Agrawal, Sanjeev;
Afzal, Obaid;
Altamimi, Abdulmalik S. A.;
Redhwan, Alya;
Alshammari, Nawaf;
Patel, Mitesh;
Adnan, Mohd;
Elasbali, Abdelbaset Mohamed;
Khan, Shahanavaj

Publication type:

Article

Differential Gene Expression and Withanolides Biosynthesis During in vitro and ex vitro Growth of Withania somnifera (L.) Dunal.

Published in:

Frontiers in Plant Science, 2022, v. 13, p. 1, doi. 10.3389/fpls.2022.917770

By:

Thorat, Sachin Ashok;
Kaniyassery, Arya;
Poojari, Poornima;
Rangel, Melissa;
Tantry, Shashikala;
Kiran, Kodsara Ramachandra;
Joshi, Manjunath B.;
Rai, Padmalatha S.;
Botha, Anna-Maria;
Muthusamy, Annamalai

Publication type:

Article

Organic cultivation of Ashwagandha with improved biomass and high content of active Withanolides: Use of Vermicompost.

Published in:

PLoS ONE, 2018, v. 13, n. 4, p. 1, doi. 10.1371/journal.pone.0194314

By:

Kaur, Amandeep;
Singh, Baldev;
Ohri, Puja;
Wang, Jia;
Wadhwa, Renu;
Kaul, Sunil C.;
Pati, Pratap Kumar;
Kaur, Arvinder

Publication type:

Article

Withanolides are Potent Novel Targeted Therapeutic Agents Against Adrenocortical Carcinomas.

Published in:

World Journal of Surgery, 2014, v. 38, n. 6, p. 1343, doi. 10.1007/s00268-014-2532-0

By:

Subramanian, Chitra;
Zhang, Huaping;
Gallagher, Robert;
Hammer, Gary;
Timmermann, Barbara;
Cohen, Mark

Publication type:

Article

Effects of moderate high temperature and UV-B on accumulation of withanolides and relative expression of the squalene synthase gene in Physalis peruviana.

Published in:

Turkish Journal of Biology, 2020, v. 44, n. 5, p. 295, doi. 10.3906/biy-2002-69

By:

ŞAHİN, Günce;
TELLİ, Murat;
ÜNLÜ, Ercan Selçuk;
PEHLİVAN KARAKAŞ, Fatma

Publication type:

Article

The cytochrome P450 enzyme WsCYP71B35 from Withania somnifera has a role in withanolides biosynthesis and defence against bacteria.

Published in:

Physiologia Plantarum, 2024, v. 176, n. 1, p. 1, doi. 10.1111/ppl.14180

By:

Shilpashree, H. B.;
Narayanan, Ananth Krishna;
Kumar, Sarma Rajeev;
Barvkar, Vitthal;
Nagegowda, Dinesh A.

Publication type:

Article

Molecular characterization of three CYP450 genes reveals their role in withanolides formation and defense in Withania somnifera, the Indian Ginseng.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-05634-9

By:

Shilpashree, H. B.;
Sudharshan, S. J.;
Shasany, Ajit K.;
Nagegowda, Dinesh A.

Publication type:

Article

β-Amyloid1-42, HIV-1Ba-L (Clade B) Infection and Drugs of Abuse Induced Degeneration in Human Neuronal Cells and Protective Effects of Ashwagandha (Withania somnifera) and Its Constituent Withanolide A.

Published in:

PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0112818

By:

Kurapati, Kesava Rao Venkata;
Samikkannu, Thangavel;
Atluri, Venkata Subba Rao;
Kaftanovskaya, Elena;
Yndart, Adriana;
Nair, Madhavan P. N.

Publication type:

Article

Withanolide A Prevents Neurodegeneration by Modulating Hippocampal Glutathione Biosynthesis during Hypoxia.

Published in:

PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0105311

By:

Baitharu, Iswar;
Jain, Vishal;
Deep, Satya Narayan;
Shroff, Sabita;
Sahu, Jayanta Kumar;
Naik, Pradeep Kumar;
Ilavazhagan, Govindasamy

Publication type:

Article

Enhanced Biosynthesis of Withanolides by Elicitation and Precursor Feeding in Cell Suspension Culture of Withania somnifera (L.) Dunal in Shake-Flask Culture and Bioreactor.

Published in:

PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0104005

By:

Sivanandhan, Ganeshan;
Selvaraj, Natesan;
Ganapathi, Andy;
Manickavasagam, Markandan

Publication type:

Article

Differential Activities of the Two Closely Related Withanolides, Withaferin A and Withanone: Bioinformatics and Experimental Evidences.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044419

By:

Vaishnavi, Kirti;
Saxena, Nishant;
Shah, Navjot;
Singh, Rumani;
Manjunath, Kavyashree;
Uthayakumar, M.;
Kanaujia, Shankar P.;
Kaul, Sunil C.;
Sekar, Kanagaraj;
Wadhwa, Renu;
Deli, Maria A.

Publication type:

Article

A Novel MMP-2 Inhibitor 3-azidowithaferin A (3-azidoWA) Abrogates Cancer Cell Invasion and Angiogenesis by Modulating Extracellular Par-4.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044039

By:

Rah, Bilal;
Amin, Hina;
Yousuf, Khalid;
Khan, Sheema;
Jamwal, Gayatri;
Mukherjee, Debaraj;
Goswami, Anindya;
Nie, Daotai

Publication type:

Article

Withanolides-Induced Breast Cancer Cell Death Is Correlated with Their Ability to Inhibit Heat Protein 90.

Published in:

PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0037764

By:

Hui-Chun Wang;
Yi-Ling Tsai;
Yang-Chang Wu;
Fang-Rong Chang;
Mei-Hsin Liu;
Wen-Ying Chen;
Chin-Chung Wu

Publication type:

Article

Drier Climatic Conditions Increase Withanolide Content of Withania coagulans Enhancing Its Inhibitory Potential Against Human Prostate Cancer Cells.

Published in:

Applied Biochemistry & Biotechnology, 2019, v. 188, n. 2, p. 460, doi. 10.1007/s12010-018-02933-8

By:

Rehman, Samiya;
Keefover-Ring, Ken;
Haq, Ihsan ul;
Dilshad, Erum;
Khan, Mohammad Imran;
Akhtar, Nosheen;
Mirza, Bushra

Publication type:

Article

Comparative Study of Withanolide Biosynthesis-Related miRNAs in Root and Leaf Tissues of Withania somnifera.

Published in:

Applied Biochemistry & Biotechnology, 2018, v. 185, n. 4, p. 1145, doi. 10.1007/s12010-018-2702-x

By:

Srivastava, Swati;
Sanchita;
Singh, Ruchi;
Srivastava, Gaurava;
Sharma, Ashok

Publication type:

Article

Impact of green synthesized WcAgNPs on in-vitro plant regeneration and withanolides production by inducing key biosynthetic genes in Withania coagulans.

Published in:

Plant Cell Reports, 2021, v. 40, n. 2, p. 283, doi. 10.1007/s00299-020-02630-z

By:

Tripathi, Deepika;
Rai, Krishna Kumar;
Pandey-Rai, Shashi

Publication type:

Article

RNAi of Sterol Methyl Transferase1 Reveals its Direct Role in Diverting Intermediates Towards Withanolide/Phytosterol Biosynthesis in Withania somnifera.

Published in:

Plant & Cell Physiology, 2019, v. 60, n. 3, p. 672, doi. 10.1093/pcp/pcy237

By:

Pal, Shaifali;
Rastogi, Shubhra;
Nagegowda, Dinesh A.;
Gupta, Madan Mohan;
Shasany, Ajit Kumar;
Chanotiya, Chandan Singh

Publication type:

Article

Sterol partitioning by HMGR and DXR for routing intermediates toward withanolide biosynthesis.

Published in:

Physiologia Plantarum, 2014, v. 152, n. 4, p. 617, doi. 10.1111/ppl.12213

By:

Singh, Shefali;
Pal, Shaifali;
Shanker, Karuna;
Chanotiya, Chandan Singh;
Gupta, Madan Mohan;
Dwivedi, Upendra Nath;
Shasany, Ajit Kumar

Publication type:

Article

Withametelin inhibits TGF-β induced Epithelial-to-Mesenchymal Transition and Programmed-Death Ligand-1 expression in vitro.

Published in:

Frontiers in Oncology, 2024, p. 01, doi. 10.3389/fonc.2024.1435516

By:

Fathima, Ashna;
Farboodniay Jahromi, Mohammad Ali;
Begum, Sajeli A.;
Jamma, Trinath

Publication type:

Article

Isolation and characterization of a bactericidal withanolide from Physalis virginiana.

Published in:

Pharmacognosy Magazine, 2012, v. 8, n. 29, p. 22, doi. 10.4103/0973-1296.93307

By:

Gibson, Kathleen A.;
Reese, R. Neil;
Halaweish, Fathi T.;
Yulin Ren

Publication type:

Article

Simultaneous Determination of Withanolide A and Bacoside A in Spansules by High-Performance Thin-Layer Chromatography.

Published in:

Indian Journal of Pharmaceutical Sciences, 2011, v. 73, n. 2, p. 240, doi. 10.4103/0250-474X.91573

By:

Shinde, P. B.;
Aragade, P. D.;
Agrawal, M. R.;
Deokate, U. A.;
Khadabadi, S. S.

Publication type:

Article

Comparative interactions of withanolides and sterols with two members of sterol glycosyltransferases from Withania somnifera.

Published in:

BMC Bioinformatics, 2015, v. 16, n. 1, p. 1, doi. 10.1186/s12859-015-0563-7

By:

Pandey, Vibha;
Dhar, Yogeshwar Vikram;
Gupta, Parul;
Bag, Sumit K.;
Atri, Neelam;
Asif, Mehar Hasan;
Trivedi, Prabodh Kumar;
Misra, Pratibha

Publication type:

Article

Optimization of Elicitation Conditions with Methyl Jasmonate and Salicylic Acid to Improve the Productivity of Withanolides in the Adventitious Root Culture of Withania somnifera (L.) Dunal.

Published in:

Applied Biochemistry & Biotechnology, 2012, v. 168, n. 3, p. 681, doi. 10.1007/s12010-012-9809-2

By:

Sivanandhan, Ganeshan;
Arun, Muthukrishnan;
Mayavan, Subramanian;
Rajesh, Manoharan;
Jeyaraj, Murugaraj;
Dev, Gnanajothi;
Manickavasagam, Markandan;
Selvaraj, Natesan;
Ganapathi, Andy

Publication type:

Article

Golden berry leaf extract containing withanolides suppresses TNF-α and IL-17 induced IL-6 expression in HeLa Cells.

Published in:

Bioscience, Biotechnology & Biochemistry, 2023, v. 87, n. 9, p. 972, doi. 10.1093/bbb/zbad070

By:

Akira Yano;
Sayaka Yuki;
Akiko Shiraishi;
Mayuka Hakozaki;
Yuko Kanno;
Ken-ichi Kimura;
Shota Uesugi

Publication type:

Article

Expression of Withania somnifera Steroidal Glucosyltransferase gene Enhances Withanolide Content in Hairy Roots.

Published in:

Plant Molecular Biology Reporter, 2016, v. 34, n. 3, p. 681, doi. 10.1007/s11105-015-0955-x

By:

Pandey, Vibha;
Srivastava, Rakesh;
Akhtar, Nehal;
Mishra, Jyoti;
Mishra, Pratibha;
Verma, Praveen

Publication type:

Article

Validated thin‐layer chromatographic method for the identification and monitoring of the effect of the extraction method on the yield and phytochemical constituents of Egyptian <italic>Withania somnifera</italic> leaves.

Published in:

Journal of Separation Science, 2018, v. 41, n. 2, p. 518, doi. 10.1002/jssc.201700764

By:

Mahrous, Rahma S. R.;
Fathy, Hoda M.;
Abu EL‐Khair, Rasha M.;
Omar, Abdallah A.

Publication type:

Article

Critical factors influencing in vitro propagation and modulation of important secondary metabolites in Withania somnifera (L.) dunal.

Published in:

Plant Cell, Tissue & Organ Culture, 2022, v. 149, n. 1/2, p. 41, doi. 10.1007/s11240-021-02225-w

By:

Kaur, Kuldeep;
Dolker, Dechen;
Behera, Shashikanta;
Pati, Pratap Kumar

Publication type:

Article

Overexpression of squalene synthase in Withania somnifera leads to enhanced withanolide biosynthesis.

Published in:

Plant Cell, Tissue & Organ Culture, 2015, v. 122, n. 2, p. 409, doi. 10.1007/s11240-015-0778-3

By:

Patel, Neha;
Patel, Parth;
Kendurkar, Shuchishweta;
Thulasiram, Hirekodathakallu;
Khan, Bashir

Publication type:

Article

Improved production of withanolides in shoot suspension culture of Withania somnifera ( L.) Dunal by seaweed extracts.

Published in:

Plant Cell, Tissue & Organ Culture, 2014, v. 119, n. 1, p. 221, doi. 10.1007/s11240-014-0521-5

By:

Sivanandhan, Ganeshan;
Selvaraj, Natesan;
Ganapathi, Andy;
Manickavasagam, Markandan

Publication type:

Article

Increased production of withanolide A, withanone, and withaferin A in hairy root cultures of Withania somnifera (L.) Dunal elicited with methyl jasmonate and salicylic acid.

Published in:

Plant Cell, Tissue & Organ Culture, 2013, v. 114, n. 1, p. 121, doi. 10.1007/s11240-013-0297-z

By:

Sivanandhan, Ganeshan;
Kapil Dev, Gnanajothi;
Jeyaraj, Murugaraj;
Rajesh, Manoharan;
Arjunan, Annavi;
Muthuselvam, Manickam;
Manickavasagam, Markandan;
Selvaraj, Natesan;
Ganapathi, Andy

Publication type:

Article

Withanolide biosynthesis recruits both mevalonate and DOXP pathways of isoprenogenesis in Ashwagandha Withania somnifera L. (Dunal).

Published in:

Plant Cell Reports, 2012, v. 31, n. 10, p. 1889, doi. 10.1007/s00299-012-1302-4

By:

Chaurasiya, Narayan;
Sangwan, Neelam;
Sabir, Farzana;
Misra, Laxminarain;
Sangwan, Rajender

Publication type:

Article

A novel approach for direct shoot regeneration, anatomical characterization, and withanolides content in micropropagated plants of Withania somnifera (L.) Dunal—an important medicinal plant.

Published in:

In Vitro Cellular & Developmental Biology Plant, 2024, v. 60, n. 3, p. 365, doi. 10.1007/s11627-024-10428-x

By:

Mahendran, Ganesan;
Rahman, Laiq ur

Publication type:

Article

Alterations in Withanolide Production in Withania Somnifera (l). Dunal Under Low Light Stress.

Published in:

Journal of Plant Science Research, 2014, v. 30, n. 2, p. 119

By:

Jacob, Lini;
R. V., Manju;
Stephen, Roy;
M. M., Viji;
Edison, Lekshmi K.

Publication type:

Article

Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0168170

By:

Seth, Chandan;
Mas, Christophe;
Conod, Arwen;
Mueller, Jens;
Siems, Karsten;
Kuciak, Monika;
Borges, Isabel;
Ruiz i Altaba, Ariel

Publication type:

Article

Traditional Horticulture Practices Increase the Production of Selected Withanolides in Withania Somnifera (L.) Dunal—A RP-UFLC Analysis.

Published in:

Journal of Chromatographic Science, 2020, v. 58, n. 10, p. 899, doi. 10.1093/chromsci/bmaa057

By:

Ankad, Gireesh M;
Pai, Sandeep R;
Hiremath, Jagadishchandra;
Hegde, Harsha V

Publication type:

Article

RP-HPLC Separation of Isomeric Withanolides: Method Development, Validation and Application to In situ Rat Permeability Determination.

Published in:

Journal of Chromatographic Science, 2017, v. 55, n. 7, p. 729, doi. 10.1093/chromsci/bmx027

By:

Malik, Mohd Yaseen;
Taneja, Isha;
Raju, Kanumuri Siva Rama;
Gayen, Jiaur Rahaman;
Wahajuddin, Muhammad;
Singh, Sheelendra Pratap;
Sangwand, Neelam S.

Publication type:

Article

Accumulation of Three Important Bioactive Compounds in Different Plant Parts of Withania somnifera and its Determination by the LC–ESI-MS-MS (MRM) Method.

Published in:

Journal of Chromatographic Science, 2015, v. 53, n. 10, p. 1749, doi. 10.1093/chromsci/bmv088

By:

Gajbhiye, Narendra A.;
Makasana, Jayanti;
Kumar, Satyanshu

Publication type:

Article

Analysis of Major Withanolides in Physalis longifolia Nutt. by HPLC-PDA.

Published in:

Journal of Chromatographic Science, 2015, v. 53, n. 7, p. 1044, doi. 10.1093/chromsci/bmu162

By:

Cong-Mei Cao;
Kindscher, Kelly;
Gallagher, Robert J.;
Huaping Zhang;
Timmermann, Barbara N.

Publication type:

Article

Oxidative Stress Induced NMDA Receptor Alteration Leads to Spatial Memory Deficits in Temporal Lobe Epilepsy: Ameliorative Effects of Withania somnifera and Withanolide A.

Published in:

Neurochemical Research, 2012, v. 37, n. 9, p. 1915, doi. 10.1007/s11064-012-0810-5

By:

Soman, Smijin;
Korah, P.;
Jayanarayanan, S.;
Mathew, Jobin;
Paulose, C.

Publication type:

Article

Exogenous applications of humic acid and salicylic acid differentially affect biomass accumulation and production of rare pharmacologically active withanolides in in vitro cultures of Withania coagulans.

Published in:

Plant Biosystems, 2025, v. 159, n. 3, p. 581, doi. 10.1080/11263504.2025.2489989

By:

Khanum, Mehnaz;
Javed, Muhammad Uzair;
Batool, Sannia;
Zaman, Gouhar;
Bajwa, Muhammad Naeem;
Andleeb, Anisa;
Garros, Laurine;
Drouet, Samantha;
Tungmunnithum, Duangjai;
Hano, Christophe;
Abbasi, Bilal Haider;
Giglioli-Guivarc'h, Nathalie

Publication type:

Article

Withaferin A and its potential role in glioblastoma (GBM).

Published in:

Journal of Neuro-Oncology, 2017, v. 131, n. 2, p. 201, doi. 10.1007/s11060-016-2303-x

By:

Dhami, Jasdeep;
Chang, Edwin;
Gambhir, Sanjiv

Publication type:

Article

Effect of Ashwagandha Withanolides on Muscle Cell Differentiation.

Published in:

Biomolecules (2218-273X), 2021, v. 11, n. 10, p. 1454, doi. 10.3390/biom11101454

By:

Wang, Jia;
Zhang, Huayue;
Kaul, Ashish;
Li, Kejuan;
Priyandoko, Didik;
Kaul, Sunil C.;
Wadhwa, Renu

Publication type:

Article

Isolation of Antidiabetic Withanolides from Withania coagulans Dunal and Their In Vitro and In Silico Validation.

Published in:

Biology (2079-7737), 2020, v. 9, n. 8, p. 197, doi. 10.3390/biology9080197

By:

Maher, Saima;
Choudhary, M. Iqbal;
Saleem, Farooq;
Rasheed, Saima;
Waheed, Imran;
Halim, Sobia Ahsan;
Azeem, Muhammad;
Abdullah, Iskandar Bin;
Froeyen, Matheus;
Mirza, Muhammad Usman;
Ahmad, Sarfraz

Publication type:

Article

A WRKY transcription factor from Withania somnifera regulates triterpenoid withanolide accumulation and biotic stress tolerance through modulation of phytosterol and defense pathways.

Published in:

New Phytologist, 2017, v. 215, n. 3, p. 1115, doi. 10.1111/nph.14663

By:

Singh, Anup Kumar;
Kumar, Sarma Rajeev;
Dwivedi, Varun;
Rai, Avanish;
Pal, Shaifali;
Shasany, Ajit K.;
Nagegowda, Dinesh A.

Publication type:

Article

Editorial: Investigating the molecular targets and therapeutic potential of Withania somnifera (Ashwagandha) in various pathophysiological conditions.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1187334

By:

Dar, Nawab John;
Bhat, Shahnawaz Ali;
Rehman, Muneeb U.;
Booker, Anthony

Publication type:

Article

BIOCHEMISTRY AND PHARMACOLOGICAL USE OF WITHANIA SOMNIFERA (ASHWGANDHA): A MEDICINAL PLANT.

Published in:

International Journal of Pharmacology & Biological Sciences, 2013, v. 7, n. 2, p. 69

By:

Sharma, Manju Lata;
Srivastava, P.;
Sharma, P.

Publication type:

Article