Works matching DE "HEPARANASE"

Results: 256

Structural Insights into Pixatimod (PG545) Inhibition of Heparanase, a Key Enzyme in Cancer and Viral Infections.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 10, p. 1, doi. 10.1002/chem.202104222

By:

Chhabra, Mohit;
Wilson, Jennifer C.;
Wu, Liang;
Davies, Gideon J.;
Gandhi, Neha S.;
Ferro, Vito

Publication type:

Article

Serum Heparanase Level Is Decreased in Stable Coronary Artery Disease.

Published in:

2019

By:

Gurbuz, Ahmet Seyfeddin;
Ozturk, Semi;
Efe, Suleyman Cagan;
Yilmaz, Mehmet Fatih;
Yanik, Raziye Ecem;
Yaman, Ali;
Kirma, Cevat;
Gurbuz, Ahmet Seyfeddin;
Efe, Suleyman Cagan;
Yilmaz, Mehmet Fatih;
Yanik, Raziye Ecem

Publication type:

journal article

Heparanase tailors syndecan for exosome production.

Published in:

2016

By:

David, Guido;
Zimmermann, Pascale

Publication type:

Opinion

Heparanase inhibitor OGT 2115 induces prostate cancer cell apoptosis via the downregulation of MCL‑1.

Published in:

Oncology Letters, 2024, v. 27, n. 2, p. N.PAG, doi. 10.3892/ol.2024.14217

By:

Li, Xin;
Xu, Shuai-Jun;
Jin, Bin;
Lu, Hong-Sheng;
Zhao, Shan-Kun;
Ding, Xiao-Fei;
Xu, Ling-Long;
Li, Hai-Jun;
Liu, Shuang-Chun;
Chen, Jie;
Chen, Guang

Publication type:

Article

MicroRNA-1258: An invasion and metastasis regulator that targets heparanase in gastric cancer.

Published in:

2021

By:

Shi, Jinxin;
Chen, Ping;
Sun, Jingxu;
Song, Yongxi;
Ma, Bin;
Gao, Peng;
Chen, Xiaowan;
Wang, Zhenning

Publication type:

Correction Notice

Heparan sulfate proteoglycans and their modification as promising anticancer targets in hepatocellular carcinoma (Review).

Published in:

Oncology Letters, 2021, v. 21, n. 2, p. 1, doi. 10.3892/ol.2021.12434

By:

ALSHEHRI, MOHAMMED A.;
ALSHEHRI, MOATH M.;
ALBALAWI, NAIF N.;
AL-GHAMDI, MOSHARI A.;
AL-GAYYAR, MOHAMMED M. H.

Publication type:

Article

MicroRNA-1258: An invasion and metastasis regulator that targets heparanase in gastric cancer.

Published in:

Oncology Letters, 2017, v. 13, n. 5, p. 3739, doi. 10.3892/ol.2017.5886

By:

JINXIN SHI;
PING CHEN;
JINGXU SUN;
YONGXI SONG;
BIN MA;
PENG GAO;
XIAOWAN CHEN;
ZHENNING WANG

Publication type:

Article

Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer.

Published in:

Oncology Letters, 2017, v. 13, n. 5, p. 3219, doi. 10.3892/ol.2017.5804

By:

BIN HU;
QING WANG;
YINGYING SHI;
SHUFANG LU;
HONGJIE QU;
LU WANG;
JINQUAN CUI

Publication type:

Article

Heparanase regulates in vitro VEGF-C expression and its clinical significance to pancreatic ductal cell adenocarcinoma.

Published in:

Oncology Letters, 2016, v. 11, n. 2, p. 1327, doi. 10.3892/ol.2016.4085

By:

BIN LV;
BIN ZHANG;
XIAO-YAN HU;
QING-DONG ZENG

Publication type:

Article

The modulation of endothelial glycocalyx by sulodexide on the porcine model of enzymatic endothelial glycocalyx damage – a pilot study.

Published in:

Clinical Hemorheology & Microcirculation, 2025, v. 89, n. 2, p. 181, doi. 10.1177/13860291241305514

By:

Astapenko, David;
Gorskaja, Diana;
Zrzavecky, Marek;
Kawashima, Hanako;
Ssali, Edward;
Navratil, Pavel;
Hana, Ludek;
Motesicky, Jan;
Radochova, Vera;
Hyspler, Radomir;
Ticha, Alena;
Lehmann, Christian;
Malbrain, Manu LNG;
Zadak, Zdenek;
Cerny, Vladimir

Publication type:

Article

A porcine model of endothelial glycocalyx damage by enzymatic digestion: A pilot study.

Published in:

Clinical Hemorheology & Microcirculation, 2021, v. 78, n. 3, p. 325, doi. 10.3233/CH-211133

By:

Astapenko, David;
Ticha, Alena;
Hyspler, Radomir;
Tomasova, Adela;
Navratil, Pavel;
Maly, Ondrej;
Parizkova, Renata Cerna;
Cizkova, Dana;
Huey, Shin Chua;
Lehmann, Christian;
Malbrain, Manu L.N.G.;
Cerny, Vladimir

Publication type:

Article

Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity.

Published in:

Oncogene, 2015, v. 34, n. 47, p. 5832, doi. 10.1038/onc.2015.40

By:

Yang, Y;
Gorzelanny, C;
Bauer, A T;
Halter, N;
Komljenovic, D;
Bäuerle, T;
Borsig, L;
Roblek, M;
Schneider, S W

Publication type:

Article

Methylene blue photodynamic therapy in malignant melanoma decreases expression of proliferating cell nuclear antigen and heparanases.

Published in:

Clinical & Experimental Dermatology, 2012, v. 37, n. 5, p. 527, doi. 10.1111/j.1365-2230.2011.04291.x

By:

Wagner, M.;
Suarez, E. R.;
Theodoro, T. R.;
Machado Filho, C. D. A. S.;
Gama, M. F. M.;
Tardivo, J. P.;
Paschoal, F. M.;
Pinhal, M. A. S.

Publication type:

Article

Splice Variant of Spalax Heparanase Skipping Exon 12.

Published in:

Genes, 2024, v. 15, n. 8, p. 1039, doi. 10.3390/genes15081039

By:

Nasser, Nicola J.;
Nevo, Eviatar;
Avivi, Aaron

Publication type:

Article

CircIMPACT: An R Package to Explore Circular RNA Impact on Gene Expression and Pathways.

Published in:

Genes, 2021, v. 12, n. 7, p. 1044, doi. 10.3390/genes12071044

By:

Buratin, Alessia;
Gaffo, Enrico;
Dal Molin, Anna;
Bortoluzzi, Stefania

Publication type:

Article

The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes.

Published in:

Transcription (2154-1264), 2012, v. 3, n. 3, p. 130, doi. 10.4161/trns.19998

By:

Yi Qing He;
Sutclife, Elissa L.;
Bunting, Karen L.;
Li, Jasmine;
Goodall, Katharine J.;
Poon, Ivan K. A.;
Hulett, Mark D.;
Freeman, Craig;
Zafar, Anjum;
McInnes, Russell L.;
Taya, Toshiki;
Parish, Christopher R.;
Rao, Sudha

Publication type:

Article

A new role for heparanase in regulating transcription.

Published in:: Nucleus (1949-1034), 2012, v. 3, n. 4, p. 313
Publication type:: Article

MicroRNA-1252-5p Associated with Extracellular Vesicles Enhances Bortezomib Sensitivity in Multiple Myeloma Cells by Targeting Heparanase.

Published in:

OncoTargets & Therapy, 2021, v. 14, p. 455, doi. 10.2147/OTT.S286751

By:

Rodrigues-Junior, Dorival Mendes;
Pelarin, Maria Fernanda de Andrade;
Nader, Helena Bonciani;
Vettore, André Luiz;
Pinhal, Maria Aparecida Silva

Publication type:

Article

Extracellular matrix as target for antitumor therapy.

Published in:

OncoTargets & Therapy, 2015, v. 8, p. 1387, doi. 10.2147/OTT.S48883

By:

Harisi, Revekka;
Jeney, Andras

Publication type:

Article

In silico investigation of heparanase-correlated genes in breast cancer subtypes.

Published in:

Einstein (16794508), 2020, v. 18, p. 1, doi. 10.31744/einstein_journal/2020AO5447

By:

Mucciolo Melo, Carina;
Pereira Prado, Henrique;
Araújo Attie, Gabriela;
Lacaz Ruiz, Daniel;
Batista Castello Girão, Manoel João;
da Silva Pinhal, Maria Aparecida

Publication type:

Article

Heparan sulfate is a plasma biomarker of acute cellular allograft rejection.

Published in:

PLoS ONE, 2018, v. 13, n. 8, p. 1, doi. 10.1371/journal.pone.0200877

By:

Barbas, Andrew S.;
Lin, Liwen;
McRae, MacKenzie;
MacDonald, Andrea L.;
Truong, Tracy;
Yang, Yiping;
Brennan, Todd V.

Publication type:

Article

Invasion and metastasis of renal cell carcinoma.

Published in:

Medical Molecular Morphology, 2014, v. 47, n. 2, p. 63, doi. 10.1007/s00795-013-0064-6

By:

Mikami, Shuji;
Oya, Mototsugu;
Mizuno, Ryuichi;
Kosaka, Takeo;
Katsube, Ken-ichi;
Okada, Yasunori

Publication type:

Article

Endothelial Dysfunction and Hemostatic System Activation in Relation to Shift Workers, Social Jetlag, and Chronotype in Female Nurses.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 2, p. 482, doi. 10.3390/ijms26020482

By:

Saharov, Gleb;
Salti, Barbara;
Bareya, Maram;
Keren-Politansky, Anat;
Fodi, Muhammed;
Shochat, Tamar;
Nadir, Yona

Publication type:

Article

Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression.

Published in:

BMC Cancer, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12885-015-1410-y

By:

Junjie Fu;
Khaybullin, Ravil;
Yanping Zhang;
Amy Xia;
Xin Qi

Publication type:

Article

Heparanase polymorphisms: influence on incidence of hepatic sinusoidal obstruction syndrome in children undergoing allogeneic hematopoietic stem cell transplantation.

Published in:

Journal of Cancer Research & Clinical Oncology, 2015, v. 141, n. 5, p. 877, doi. 10.1007/s00432-014-1857-2

By:

Seifert, Claudia;
Wittig, Susan;
Arndt, Clemens;
Gruhn, Bernd

Publication type:

Article

In vitro and in vivo evaluation of DC-targeting PLGA nanoparticles encapsulating heparanase CD4<sup>+</sup> and CD8<sup>+</sup> T-cell epitopes for cancer immunotherapy.

Published in:

Cancer Immunology, Immunotherapy, 2022, v. 71, n. 12, p. 2969, doi. 10.1007/s00262-022-03209-1

By:

Tang, Xu-Dong;
Lü, Kui-Lin;
Yu, Jin;
Du, Han-Jian;
Fan, Chao-Qiang;
Chen, Lei

Publication type:

Article

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain.

Published in:

Acta Neuropathologica, 2012, v. 124, n. 4, p. 465, doi. 10.1007/s00401-012-0997-1

By:

Zhang, Xiao;
Wang, Bo;
O'Callaghan, Paul;
Hjertström, Elina;
Jia, Juan;
Gong, Feng;
Zcharia, Eyal;
Nilsson, Lars;
Lannfelt, Lars;
Vlodavsky, Israel;
Lindahl, Ulf;
Li, Jin-Ping

Publication type:

Article

Heparanase/Syndecan-1 Axis Regulates the Grade of Liver Cancer and Proliferative Ability of Hepatocellular Carcinoma Cells.

Published in:

Oncologie (Tech Science Press), 2022, v. 24, n. 3, p. 539, doi. 10.32604/oncologie.2022.024882

By:

Shengjin Yu;
Huiming Lv;
Jinhui Zhang;
He Zhang;
Weiwei Ju;
Yu Jiang;
Lijuan Lin

Publication type:

Article

Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer's disease.

Published in:

Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01182-x

By:

Zhang, Xiao;
O'Callaghan, Paul;
Li, Honglian;
Tan, Yingxia;
Zhang, Ganlin;
Barash, Uri;
Wang, Xiaomin;
Lannfelt, Lars;
Vlodavsky, Israel;
Lindahl, Ulf;
Li, Jin-Ping

Publication type:

Article

Author Correction: Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling.

Published in:

2021

By:

Kiyan, Yulia;
Tkachuk, Sergey;
Kurselis, Kestutis;
Shushakova, Nelli;
Stahl, Klaus;
Dawodu, Damilola;
Kiyan, Roman;
Chichkov, Boris;
Haller, Hermann

Publication type:

Correction Notice

Heparanase inhibition preserves the endothelial glycocalyx in lung grafts and improves lung preservation and transplant outcomes.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-91777-0

By:

Noda, Kentaro;
Philips, Brian J.;
Snyder, Mark E.;
Phillippi, Julie A.;
Sullivan, Mara;
Stolz, Donna B.;
Ren, Xi;
Luketich, James D.;
Sanchez, Pablo G.

Publication type:

Article

Nuclear Heparanase Regulates Chromatin Remodeling, Gene Expression and PTEN Tumor Suppressor Function.

Published in:

Cells (2073-4409), 2020, v. 9, n. 9, p. 2038, doi. 10.3390/cells9092038

By:

Amin, Rada;
Tripathi, Kaushlendra;
Sanderson, Ralph D.

Publication type:

Article

Heparanase: A Multitasking Protein Involved in Extracellular Matrix (ECM) Remodeling and Intracellular Events.

Published in:

Cells (2073-4409), 2018, v. 7, n. 12, p. 236, doi. 10.3390/cells7120236

By:

Masola, Valentina;
Bellin, Gloria;
Gambaro, Giovanni;
Onisto, Maurizio

Publication type:

Article

Identification of Novel Potential Heparanase Inhibitors Using Virtual Screening.

Published in:

Catalysts (2073-4344), 2022, v. 12, n. 5, p. 503, doi. 10.3390/catal12050503

By:

Rus, Alfredo;
Bolanos-Garcia, Victor M.;
Bastida, Agatha;
Morales, Paula

Publication type:

Article

Role of heparanase in pulmonary hypertension.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1202676

By:

Lin-Jun Wang;
Fei Feng;
Jian-Chun Li;
Ting-Ting Chen;
Li-Ping Liu

Publication type:

Article

Heparanase is a predictive marker for high thrombus burden in patients with ST-segment elevation myocardial infarction.

Published in:

Biomarkers, 2019, v. 24, n. 6, p. 600, doi. 10.1080/1354750X.2019.1628809

By:

Gurbuz, Ahmet Seyfeddin;
Ozturk, Semi;
Efe, Suleyman Cagan;
Yılmaz, Mehmet Fatih;
Yanik, Raziye Ecem;
Yaman, Ali;
Kirma, Cevat

Publication type:

Article

Recent data concerning heparanase: focus on fibrosis, inflammation and cancer.

Published in:

Biomolecular Concepts, 2015, v. 6, n. 5/6, p. 415, doi. 10.1515/bmc-2015-0021

By:

Secchi, Maria Francesca;
Masola, Valentina;
Zaza, Gianluigi;
Lupo, Antonio;
Gambaro, Giovanni;
Onisto, Maurizio

Publication type:

Article

The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer.

Published in:

Breast Cancer Research, 2024, v. 26, n. 1, p. 1, doi. 10.1186/s13058-024-01906-6

By:

Manouchehri, Jasmine M.;
Datta, Jharna;
Marcho, Lynn M.;
Reardon, Jesse J.;
Stover, Daniel;
Wesolowski, Robert;
Borate, Uma;
Cheng, Ting-Yuan David;
Schnell, Patrick M.;
Ramaswamy, Bhuvaneswari;
Sizemore, Gina M.;
Rubinstein, Mark P.;
Cherian, Mathew A.

Publication type:

Article

The Role of Heparanase in Pulmonary Cell Recruitment in Response to an Allergic but Not Non-Allergic Stimulus.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0127032

By:

Morris, Abigail;
Wang, Bo;
Waern, Ida;
Venkatasamy, Radhakrishnan;
Page, Clive;
Schmidt, Eric P.;
Wernersson, Sara;
Li, Jin-Ping;
Spina, Domenico

Publication type:

Article

Nephroprotective Effect of Heparanase in Experimental Nephrotic Syndrome.

Published in:

PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0119610

By:

Assady, Suheir;
Alter, Joel;
Axelman, Elena;
Zohar, Yaniv;
Sabo, Edmond;
Litvak, Michael;
Kaplan, Marielle;
Ilan, Neta;
Vlodavsky, Israel;
Abassi, Zaid

Publication type:

Article

Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4.

Published in:

PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0109596

By:

Goodall, Katharine J.;
Poon, Ivan K. H.;
Phipps, Simon;
Hulett, Mark D.

Publication type:

Article

Anti-Heparanase Aptamers as Potential Diagnostic and Therapeutic Agents for Oral Cancer.

Published in:

PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0096846

By:

Simmons, Suzanne C.;
Jämsä, Hannaleena;
Silva, Dilson;
Cortez, Celia M.;
McKenzie, Edward A.;
Bitu, Carolina C.;
Salo, Sirpa;
Nurmenniemi, Sini;
Nyberg, Pia;
Risteli, Juha;
deAlmeida, Carlos E. B.;
Brenchley, Paul E. C.;
Salo, Tuula;
Missailidis, Sotiris

Publication type:

Article

The Protective Role of Fucosylated Chondroitin Sulfate, a Distinct Glycosaminoglycan, in a Murine Model of Streptozotocin-Induced Diabetic Nephropathy.

Published in:

PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0106929

By:

Gomes, Conrado L. R.;
Leão, Cristina L.;
Venturotti, Carolina;
Barreira, André L.;
Guimarães, Gabriela;
Fonseca, Roberto J. C.;
Fortunato, Rodrigo S.;
Mourão, Paulo A. S.;
Delgado, Alvimar G.;
Takiya, Christina M.;
Leite Jr, Maurilo

Publication type:

Article

DNA Methylation of Heparanase Promoter Influences Its Expression and Associated with the Progression of Human Breast Cancer.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0092190

By:

Jiao, Fei;
Bai, Shi-yu;
Ma, Ying;
Yan, Zhong-hai;
Yue, Zhen;
Yu, Yuan;
Wang, Xin;
Wang, Juan

Publication type:

Article

Heparanase Interacts with Resistin and Augments Its Activity.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0085944

By:

Novick, Daniela;
Barak, Sara;
Ilan, Neta;
Vlodavsky, Israel

Publication type:

Article

Synthesis of a Pseudo-Disaccharide Library and Its Application to the Characterisation of the Heparanase Catalytic Site.

Published in:

PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0082111

By:

Vinader, Victoria;
Haji-Abdullahi, Mohamed H.;
Patterson, L. H.;
Afarinkia, Kamyar

Publication type:

Article

EGFR, FLT1 and Heparanase as Markers Identifying Patients at Risk of Short Survival in Cholangiocarcinoma

Published in:

PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0064186

By:

Hoffmann, Andreas-Claudius;
Goekkurt, Eray;
Danenberg, Peter V.;
Lehmann, Sylvia;
Ehninger, Gerhard;
Aust, Daniela E.;
Stoehlmacher-Williams, Jan

Publication type:

Article

Synthesized Multiple Antigenic Polypeptide Vaccine Based on B-Cell Epitopes of Human Heparanase Could Elicit a Potent Antimetastatic Effect on Human Hepatocellular Carcinoma In Vivo.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0052940

By:

Jun Zhang;
Jian-min Yang;
Hui-ju Wang;
Guo-qing Ru;
Dai-ming Fan

Publication type:

Article

Clinical Significance of Heparanase Splice Variant (T5) in Renal Cell Carcinoma: Evaluation by a Novel T5-Specific Monoclonal Antibody.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0051494

By:

Barash, Uri;
Arvatz, Gil;
Farfara, Roy;
Naroditsky, Inna;
Doweck, Ilana;
Feld, Sari;
Ben-Izhak, Ofer;
Ilan, Neta;
Nativ, Ofer;
Vlodavsky, Israel

Publication type:

Article

Elevated Urine Heparanase Levels Are Associated with Proteinuria and Decreased Renal Allograft Function.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044076

By:

Shafat, Itay;
Agbaria, Amir;
Boaz, Mona;
Schwartz, Doron;
Baruch, Ronny;
Nakash, Richard;
Ilan, Neta;
Vlodavsky, Israel;
Weinstein, Talia;
Câmara, Niels Olsen Saraiva

Publication type:

Article