Effect of combination therapy (ribavirin and interferon) in HCV‐related glomerulopathy.

Sabry, Alaa A.; Sobh, Mohamed A.; Sheaashaa, Hussein A.; Kudesia, Guara; Wild, Graham; Fox, Samantha; Wagner, Bart E.; Irving, William L.; Grabowska, Anna; El‐Nahas, Abdel Meguid

Background. Hepatitis C virus (HCV) is a major cause of acute and chronic hepatitis throughout the world. Several extrahepatic manifestations, including glomerulonephritis, have been reported to be associated with this type of infection. Cryoglobulinaemic and non‐cryoglobulinaemic membranoproliferative glomerulonephritis (MPGN) and membranous nephropathy (MN) are the commonest lesions associated with HCV. Results of treatment of these patients with interferon therapy have been disappointing, since relapse of the viraemia and subsequent relapse of the renal disease are major problems. Combination of interferon with ribavirin in patients with chronic liver disease has been shown to increase the rate of sustained response.

Nephrology Dialysis Transplantation, 2002, Vol 17, Issue 11, p1924

0931-0509

Academic Journal

10.1093/ndt/17.11.1924