Works matching IS 03051048 AND DT 2022 AND VI 50 AND IP 4
Results: 45
Flexible TALEs for an expanded use in gene activation, virulence and scaffold engineering.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2387, doi. 10.1093/nar/gkac098
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DNA methylation cues in nucleosome geometry, stability and unwrapping.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 1864, doi. 10.1093/nar/gkac097
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structure of AcrIE4-F7 reveals a common strategy for dual CRISPR inhibition by targeting PAM recognition sites.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2363, doi. 10.1093/nar/gkac096
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Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast cancer.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 1829, doi. 10.1093/nar/gkac090
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Endogenous retroviruses co-opted as divergently transcribed regulatory elements shape the regulatory landscape of embryonic stem cells.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2111, doi. 10.1093/nar/gkac088
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interaction between RPAP3 and TRBP reveals a possible involvement of the HSP90/R2TP chaperone complex in the regulation of miRNA activity.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2172, doi. 10.1093/nar/gkac086
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Structural effects of m6A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2350, doi. 10.1093/nar/gkac080
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Physical ARTEMIS:DNA-PKcs interaction is necessary for V(D)J recombination.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2096, doi. 10.1093/nar/gkac071
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- Article
High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2157, doi. 10.1093/nar/gkac070
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Transcription-replication coordination revealed in single live cells.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2143, doi. 10.1093/nar/gkac069
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Synthetic robust perfect adaptation achieved by negative feedback coupling with linear weak positive feedback.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2377, doi. 10.1093/nar/gkac066
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non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2081, doi. 10.1093/nar/gkac065
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- Article
Epitranscriptomic regulation of HIV-1 full-length RNA packaging.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2302, doi. 10.1093/nar/gkac062
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low-resolution structural models of hepatitis C virus RNA subdomain 5BSL3.2 and its distal complex with domain 3′X point to conserved regulatory mechanisms within the Flaviviridae family.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2287, doi. 10.1093/nar/gkac061
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- Article
Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2128, doi. 10.1093/nar/gkac058
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Prediction and pan-cancer analysis of mammalian transcripts involved in target directed miRNA degradation.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2019, doi. 10.1093/nar/gkac057
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- Article
Commonality and diversity in tRNA substrate recognition in t6A biogenesis by eukaryotic KEOPSs.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2223, doi. 10.1093/nar/gkac056
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RBFOX2 is required for establishing RNA regulatory networks essential for heart development.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2270, doi. 10.1093/nar/gkac055
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- Article
Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2005, doi. 10.1093/nar/gkac054
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Origin of life: protoribosome forms peptide bonds and links RNA and protein dominated worlds.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 1815, doi. 10.1093/nar/gkac052
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- Article
Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 1993, doi. 10.1093/nar/gkac051
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Evolutionary rewiring of regulatory networks contributes to phenotypic differences between human and mouse orthologous genes.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 1849, doi. 10.1093/nar/gkac050
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transcriptional elongation factor CTR9 demarcates PRC2-mediated H3K27me3 domains by altering PRC2 subtype equilibrium.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 1969, doi. 10.1093/nar/gkac047
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Eukaryotic stress–induced mutagenesis is limited by a local control of translesion synthesis.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2074, doi. 10.1093/nar/gkac044
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Mechanistic decoupling of exonuclease III multifunctionality into AP endonuclease and exonuclease activities at the single-residue level.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2211, doi. 10.1093/nar/gkac043
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Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 1951, doi. 10.1093/nar/gkac042
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RadD is a RecA-dependent accessory protein that accelerates DNA strand exchange.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2201, doi. 10.1093/nar/gkac041
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RNA modifications stabilize the tertiary structure of tRNAfMet by locally increasing conformational dynamics.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2334, doi. 10.1093/nar/gkac040
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Folding of VemP into translation-arresting secondary structure is driven by the ribosome exit tunnel.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2258, doi. 10.1093/nar/gkac038
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Genomic patterns of transcription–replication interactions in mouse primary B cells.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2051, doi. 10.1093/nar/gkac035
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Gain of C-Ala enables AlaRS to target the L-shaped tRNAAla.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2190, doi. 10.1093/nar/gkac026
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POLIE suppresses telomerase-mediated telomere G-strand extension and helps ensure proper telomere C-strand synthesis in trypanosomes.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2036, doi. 10.1093/nar/gkac023
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Elongation factor TFIIS is essential for heat stress adaptation in plants.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 1927, doi. 10.1093/nar/gkac020
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Nuclear export restricts Gdown1 to a mitotic function.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 1908, doi. 10.1093/nar/gkac015
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Analysis of epigenetic features characteristic of L1 loci expressed in human cells.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 1888, doi. 10.1093/nar/gkac013
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Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2240, doi. 10.1093/nar/gkab606
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Chaperone mediated autophagy contributes to the newly synthesized histones H3 and H4 quality control.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 1875, doi. 10.1093/nar/gkab1296
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Role of PemI in the Staphylococcus aureus PemIK toxin–antitoxin complex: PemI controls PemK by acting as a PemK loop mimic.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 2319, doi. 10.1093/nar/gkab1288
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Analysis of subcellular transcriptomes by RNA proximity labeling with Halo-seq.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. e24, doi. 10.1093/nar/gkab1185
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Phospho-RNA sequencing with circAID-p-seq.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. e23, doi. 10.1093/nar/gkab1158
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OUHP: an optimized universal hairpin primer system for cost-effective and high-throughput RT-qPCR-based quantification of microRNA (miRNA) expression.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. e22, doi. 10.1093/nar/gkab1153
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Effective and scalable single-cell data alignment with non-linear canonical correlation analysis.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. e21, doi. 10.1093/nar/gkab1147
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CRISPRroots: on- and off-target assessment of RNA-seq data in CRISPR–Cas9 edited cells.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. e20, doi. 10.1093/nar/gkab1131
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Accurate expression quantification from nanopore direct RNA sequencing with NanoCount.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. e19, doi. 10.1093/nar/gkab1129
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RNase H is an exo- and endoribonuclease with asymmetric directionality, depending on the binding mode to the structural variants of RNA:DNA hybrids.
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- Nucleic Acids Research, 2022, v. 50, n. 4, p. 1801, doi. 10.1093/nar/gkab1064
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