Works matching DE "CHECKPOINT kinase 1"
Results: 145
Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response.
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- Molecular Systems Biology, 2025, v. 21, n. 3, p. 231, doi. 10.1038/s44320-025-00085-6
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The role of USP51 in attenuating chemosensitivity of lung cancer cells to cisplatin by regulating DNA damage response.
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- Biotechnology & Applied Biochemistry, 2023, v. 70, n. 2, p. 634, doi. 10.1002/bab.2386
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- Article
Synthesis and preliminary structure-activity relationship study of 2-aryl-2H-pyrazolo[4,3-c]quinolin-3-ones as potential checkpoint kinase 1 (Chk1) inhibitors.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2018, v. 33, n. 1, p. 171, doi. 10.1080/14756366.2017.1404592
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Exosomes derived from hUC-MSCs exhibit ameliorative efficacy upon previous cesarean scar defect via orchestrating β-TrCP/CHK1 axis.
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- Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-024-84689-2
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- Article
Gynecologic Cancer InterGroup CA125 response has a high negative predictive value for CHK1 inhibitor RECIST response in recurrent ovarian cancer.
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- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-68338-2
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- Article
Correction: Hsiao et al. Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses. Biomolecules 2023, 13 , 125.
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- 2023
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- Correction Notice
Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses.
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- Biomolecules (2218-273X), 2023, v. 13, n. 1, p. 125, doi. 10.3390/biom13010125
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- Article
Brooding Temperature Alters Yolk Sac Absorption and Affected Ovarian Development in Goslings.
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- Animals (2076-2615), 2022, v. 12, n. 12, p. 1513, doi. 10.3390/ani12121513
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Exploration of the carcinogenetic and immune role of CHK1 in human cancer.
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- Journal of Cancer, 2024, v. 15, n. 18, p. 5927, doi. 10.7150/jca.93930
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- Article
Clinically relevant CHK1 inhibitors abrogate wild-type and Y537S mutant ERα expression and proliferation in luminal primary and metastatic breast cancer cells.
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- Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02360-y
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- Article
HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer.
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- Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02258-9
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- Article
Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomas.
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- Pigment Cell & Melanoma Research, 2024, v. 37, n. 1, p. 45, doi. 10.1111/pcmr.13120
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- Article
A multi-omics analysis reveals CLSPN is associated with prognosis, immune microenvironment and drug resistance in cancers.
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- Biological Procedures Online, 2023, v. 25, n. 1, p. 1, doi. 10.1186/s12575-023-00201-6
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- Article
Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response.
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- Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09431-7
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- Article
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway.
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- Biochemical Journal, 2022, v. 479, n. 19, p. 2063, doi. 10.1042/BCJ20220102
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- Article
Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance.
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- Biochemical Journal, 2022, v. 479, n. 19, p. 2087, doi. 10.1042/BCJ20220089
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- Article
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells.
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- Biochemical Journal, 2022, v. 479, n. 19, p. 2131, doi. 10.1042/BCJ20220103
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- Article
STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells.
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- BMC Molecular & Cell Biology, 2021, v. 22, n. 1, p. 1, doi. 10.1186/s12860-021-00352-y
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- Article
The cytosolic iron–sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors.
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- NPJ Breast Cancer, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41523-021-00353-2
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- Article
Vitamin-Containing Antioxidant Formulation Reduces Carcinogen-Induced DNA Damage through ATR/Chk1 Signaling in Bronchial Epithelial Cells In Vitro.
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- Biomedicines, 2021, v. 9, n. 11, p. 1665, doi. 10.3390/biomedicines9111665
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- Article
Deletion of Non-histidine Domains of Histidine Kinase CHK1 Diminishes the Infectivity of Candida albicans in an Oral Mucosal Model.
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- Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.855651
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- Article
Combination Therapies with Kinase Inhibitors for Acute Myeloid Leukemia Treatment.
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- Hematology Reports, 2023, v. 15, n. 2, p. 331, doi. 10.3390/hematolrep15020035
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- Article
The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.
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- Oncogene, 2008, v. 27, n. 28, p. 3977, doi. 10.1038/onc.2008.17
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- Article
Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options.
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- Molecular Medicine, 2023, v. 29, n. 1, p. 1, doi. 10.1186/s10020-023-00636-3
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- Article
Relationship between DNA mismatch repair and CRISPR/Cas9-mediated knock-in in the bovine β-casein gene locus.
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- Animal Bioscience, 2022, v. 35, n. 1, p. 126, doi. 10.5713/ab.21.0117
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- Article
XRCC2 driven homologous recombination subtypes and therapeutic targeting in lung adenocarcinoma metastasis.
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- NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00658-y
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- Article
Suppressive effects of umbilical cord mesenchymal stem cell-derived exosomal miR-15a-5p on the progression of cholangiocarcinoma by inhibiting CHEK1 expression.
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- Cell Death Discovery, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41420-022-00932-7
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- Article
BUB- 1 and CENP- C recruit PLK- 1 to control chromosome alignment and segregation during meiosis I in C. elegans oocytes.
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- eLife, 2023, p. 1, doi. 10.7554/eLife.84057
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- Article
Advances in ATM, ATR, WEE1, and CHK1/2 inhibitors in the treatment of PARP inhibitor-resistant ovarian cancer.
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- Cancer Biology & Medicine, 2023, v. 20, n. 12, p. 915, doi. 10.20892/j.issn.2095-3941.2023.0260
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Liquid-liquid phase separation in DNA double-strand break repair.
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- Cancer Biology & Medicine, 2023, v. 20, n. 9, p. 627, doi. 10.20892/j.issn.2095-3941.2023.0252
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- Article
Inhibition of Chk1 with Prexasertib Enhances the Anticancer Activity of Ciclopirox in Non-Small Cell Lung Cancer Cells.
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- Cells (2073-4409), 2024, v. 13, n. 21, p. 1752, doi. 10.3390/cells13211752
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A Novel Approach: Investigating the Intracellular Clearance Mechanism of Glyceraldehyde-Derived Advanced Glycation End-Products Using the Artificial Checkpoint Kinase 1 d270KD Mutant as a Substrate Model.
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- Cells (2073-4409), 2023, v. 12, n. 24, p. 2838, doi. 10.3390/cells12242838
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Chrysin-Induced Regression of Angiogenesis via an Induction of DNA Damage Response and Oxidative Stress in In Vitro and In Vivo Models of Melanoma.
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- Cells (2073-4409), 2023, v. 12, n. 12, p. 1561, doi. 10.3390/cells12121561
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- Article
The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G 2 -Checkpoint Activation in Cells Exposed to Ionizing Radiation.
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- Cells (2073-4409), 2023, v. 12, n. 10, p. 1387, doi. 10.3390/cells12101387
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- Article
The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous BRCA MUT and BRCA WT Ovarian Cancer Cells.
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- Cells (2073-4409), 2022, v. 11, n. 12, p. 1889, doi. 10.3390/cells11121889
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- Article
Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer.
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- Cells (2073-4409), 2020, v. 9, n. 1, p. 1, doi. 10.3390/cells9010238
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- Article
Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm.
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- Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.1016683
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- Article
Transcriptional Differential Analysis of Nitazoxanide-Mediated Anticanine Parvovirus Effect in F81 Cells.
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- Viruses (1999-4915), 2024, v. 16, n. 2, p. 282, doi. 10.3390/v16020282
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- Article
Chk1 and the Host Cell DNA Damage Response as a Potential Antiviral Target in BK Polyomavirus Infection.
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- Viruses (1999-4915), 2021, v. 13, n. 7, p. 1353, doi. 10.3390/v13071353
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- Article
FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation.
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- Journal of Experimental & Clinical Cancer Research (17569966), 2023, v. 42, n. 1, p. 1, doi. 10.1186/s13046-023-02630-3
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- Article
Curcumin suppresses cell viability in breast cancer cell line by affecting the expression of miR-15a-5p.
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- Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2024, v. 49, n. 5, p. 656, doi. 10.1515/tjb-2024-0031
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- Article
The KRAS, ATR and CHEK1 expression levels in endometrial cancer are the risk factors predicting recurrence.
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- PLoS ONE, 2024, v. 19, n. 4, p. 1, doi. 10.1371/journal.pone.0302075
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- Article
Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition.
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- Journal of Pathology, 2023, v. 259, n. 2, p. 194, doi. 10.1002/path.6032
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Orchestrating smart therapeutics to achieve optimal treatment in small cell lung cancer: recent progress and future directions.
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- Journal of Translational Medicine, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12967-023-04338-6
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- Article
DAP3-mediated cell cycle regulation and its association with radioresistance in human lung adenocarcinoma cell lines.
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- Journal of Radiation Research, 2023, v. 64, n. 3, p. 520, doi. 10.1093/jrr/rrad016
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- Article
Activity-based protein profiling and global proteome analysis reveal MASTL as a potential therapeutic target in gastric cancer.
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- Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01783-8
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- Article
Regulation of Mus81-Eme1 structure-specific endonuclease by Eme1 SUMO-binding and Rad3<sup>ATR</sup> kinase is essential in the absence of Rqh1<sup>BLM</sup> helicase.
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- PLoS Genetics, 2022, v. 18, n. 4, p. 1, doi. 10.1371/journal.pgen.1010165
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- Article
Inhibition of Chk1 stimulates cytotoxic action of platinum-based drugs and TRAIL combination in human prostate cancer cells.
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- Biological Chemistry, 2024, v. 405, n. 6, p. 395, doi. 10.1515/hsz-2023-0111
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- Article
Relative free-energy calculations for scaffold hopping-type transformations with an automated RE-EDS sampling procedure.
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- Journal of Computer-Aided Molecular Design, 2022, v. 36, n. 2, p. 117, doi. 10.1007/s10822-021-00436-z
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- Article
Combination of S-1 and the oral ATR inhibitor ceralasertib is effective against pancreatic cancer cells.
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- Cancer Chemotherapy & Pharmacology, 2024, v. 94, n. 6, p. 763, doi. 10.1007/s00280-024-04716-x
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- Article