Title: Neutrophils on the mast cell menu.
Authors: Espinosa, Eric
Abstract: A recent article in Cell reported a new peculiar interaction between mast cells (MCs) and neutrophils. Upon IgE/Ag-mediated degranulation, MCs produce leukotriene B4, which attracts migrating neutrophils. Some neutrophils are able to establish close contact with MCs and end up trapped inside the MC, forming a cell-in-cell structure. While the neutrophil eventually dies inside the vacuole, the MC benefits from the remains of its prisoner, using it as a nutrient reserve and reusing its antimicrobial weapons.
Subjects: MAST cells; NEUTROPHILS; PRISONERS; WEAPONS
Publication: Journal of Leukocyte Biology, 2024, Vol 116, Issue 6, p1217
ISSN: 0741-5400
Publication type: Academic Journal
DOI: 10.1093/jleuko/qiae221

Neutrophils on the mast cell menu.

Espinosa, Eric