In a sticky situation: pro-coagulant properties expand the importance of neutrophil EVs in driving tissue injury.

Madison, Matthew C; Finley, Dakota C; Genschmer, Kristopher R

The article explores the role of neutrophil extracellular vesicles (EVs) in driving tissue injury, particularly in the context of coagulation responses to bacterial infections. Neutrophil-derived EVs have been shown to initiate the formation of active thrombin, contributing to coagulopathies associated with sepsis. The study highlights the diverse functions of neutrophil EVs, including their ability to drive extracellular matrix degradation, induce inflammation, and promote endothelial damage. While neutrophil EVs play a role in immune function and tissue homeostasis, their excessive activity can lead to detrimental effects in conditions like sepsis, paving the way for further research in this area.

LEUKOCYTE elastase; CELL physiology; COAGULATION; CHRONIC obstructive pulmonary disease; MATRIX metalloproteinases; EXTRACELLULAR matrix

Journal of Leukocyte Biology, 2024, Vol 116, Issue 6, p1220

0741-5400

Academic Journal

10.1093/jleuko/qiae185