Results
Title

Bacterial efflux pump OMPs as vaccine candidates against multidrug-resistant Gram-negative bacteria.

Authors

Silva, Thaynara O; Bulla, Ana Carolina S; Teixeira, Bárbara A; Gomes, Vinnicius Machado Schelk; Raposo, Thiago; Barbosa, Luiza S; Silva, Manuela Leal da; Moreira, Lilian O; Olsen, Priscilla C

Abstract

The emergence and propagation of bacteria resistant to antimicrobial drugs is a serious public health threat worldwide. The current antibacterial arsenal is becoming obsolete, and the pace of drug development is decreasing, highlighting the importance of investment in alternative approaches to treat or prevent infections caused by antimicrobial-resistant bacteria. A significant mechanism of antimicrobial resistance employed by Gram-negative bacteria is the overexpression of efflux pumps that can extrude several compounds from the bacteria, including antimicrobials. The overexpression of efflux pump proteins has been detected in several multidrug-resistant Gram-negative bacteria, drawing attention to these proteins as potential targets against these pathogens. This review will focus on the role of outer membrane proteins from efflux pumps as potential vaccine candidates against clinically relevant multidrug-resistant Gram-negative bacteria, discussing advantages and pitfalls. Additionally, we will explore the relevance of efflux pump outer membrane protein diversity and the possible impact of vaccination on microbiota.

Subjects

GRAM-negative bacteria; MEMBRANE proteins; ALTERNATIVE investments; DRUG resistance in microorganisms; DRUG development

Publication

Journal of Leukocyte Biology, 2024, Vol 116, Issue 6, p1237

ISSN

0741-5400

Publication type

Academic Journal

DOI

10.1093/jleuko/qiae154