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- Title
Bacterial efflux pump OMPs as vaccine candidates against multidrug-resistant Gram-negative bacteria.
- Authors
Silva, Thaynara O; Bulla, Ana Carolina S; Teixeira, Bárbara A; Gomes, Vinnicius Machado Schelk; Raposo, Thiago; Barbosa, Luiza S; Silva, Manuela Leal da; Moreira, Lilian O; Olsen, Priscilla C
- Abstract
The emergence and propagation of bacteria resistant to antimicrobial drugs is a serious public health threat worldwide. The current antibacterial arsenal is becoming obsolete, and the pace of drug development is decreasing, highlighting the importance of investment in alternative approaches to treat or prevent infections caused by antimicrobial-resistant bacteria. A significant mechanism of antimicrobial resistance employed by Gram-negative bacteria is the overexpression of efflux pumps that can extrude several compounds from the bacteria, including antimicrobials. The overexpression of efflux pump proteins has been detected in several multidrug-resistant Gram-negative bacteria, drawing attention to these proteins as potential targets against these pathogens. This review will focus on the role of outer membrane proteins from efflux pumps as potential vaccine candidates against clinically relevant multidrug-resistant Gram-negative bacteria, discussing advantages and pitfalls. Additionally, we will explore the relevance of efflux pump outer membrane protein diversity and the possible impact of vaccination on microbiota.
- Subjects
GRAM-negative bacteria; MEMBRANE proteins; ALTERNATIVE investments; DRUG resistance in microorganisms; DRUG development
- Publication
Journal of Leukocyte Biology, 2024, Vol 116, Issue 6, p1237
- ISSN
0741-5400
- Publication type
Academic Journal
- DOI
10.1093/jleuko/qiae154