Works matching Hirano Toshio

Results: 72

Interview with Dr Toshio Hirano.

Published in:: International Immunology, 2021, v. 33, n. 12, p. 623, doi. 10.1093/intimm/dxab084
Publication type:: Article

Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis.

Published in:

European Journal of Immunology, 1988, v. 18, n. 11, p. 1797, doi. 10.1002/eji.1830181122

By:

Hirano, Toshio;
Matsuda, Tadashi;
Turner, Martin;
Miyasaka, Nobuyuki;
Buchan, Glenn;
Tang, Bo;
Sato, Kazuto;
Shimi, Masatoshi;
Maid, Ravinder;
Feldmann, Marc;
Kishimoto, Tadamitsu

Publication type:

Article

Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2-dependent cell line and preparation of anti-IL 6 monoclonal antibodies.

Published in:

European Journal of Immunology, 1988, v. 18, n. 6, p. 951, doi. 10.1002/eji.1830180618

By:

Matsuda, Tadashi;
And, Toshio Hirano;
Kishimoto, Tadamitsu

Publication type:

Article

Induction of rat acute-phase proteins by interleukin 6 in vivo.

Published in:

European Journal of Immunology, 1988, v. 18, n. 5, p. 717, doi. 10.1002/eji.1830180510

By:

Geiger, Thomas;
Andus, Tilo;
Klapproth, Jan;
Hirano, Toshio;
Kishimoto, Tadamitsu;
Heinrich, Peter C.

Publication type:

Article

Action of recombinant human interleukin 6, interleukin 1β and tumor necrosis factor α on the mRNA induction of acute-phase proteins.

Published in:

European Journal of Immunology, 1988, v. 18, n. 5, p. 739, doi. 10.1002/eji.1830180513

By:

Andus, Tilo;
Geiger, Thomas;
Hirano, Toshio;
Kishimoto, Tadamitsu;
Heinrich, Peter C.

Publication type:

Article

Activation of Stat3 by v-Src Is through a Ras-Independent Pathway.

Published in:

Journal of Biomedical Science, 1998, v. 5, n. 6, p. 446, doi. 10.1159/000025360

By:

Jan-Jan Liu;
Nakajima, Koichi;
Hirano, Toshio;
Hsin-Fang Yang-Yen

Publication type:

Article

TRIF–GEFH1–RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation.

Published in:

EMBO Journal, 2006, v. 25, n. 17, p. 4108, doi. 10.1038/sj.emboj.7601286

By:

Kamon, Hokuto;
Kawabe, Takaya;
Kitamura, Hidemitsu;
Lee, Jihye;
Kamimura, Daisuke;
Kaisho, Tsuneyasu;
Akira, Shizuo;
Iwamatsu, Akihiro;
Koga, Hisashi;
Murakami, Masaaki;
Hirano, Toshio

Publication type:

Article

Gab11 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation.

Published in:

Journal of Cell Biology, 2002, v. 159, n. 1, p. 103, doi. 10.1083/jcb.200205017

By:

Ti Cai;
Nishida, Keigo;
Hirano, Toshio;
Khavari, Paul A.

Publication type:

Article

Mini Review.

Published in:

Growth Factors, 2004, v. 22, n. 2, p. 75, doi. 10.1080/08977190410001715181

By:

Murakami, Masaaki;
Kamimura, Daisuke;
Hirano, Toshio

Publication type:

Article

Signaling Through Gp130: Toward a General Scenario of Cytokine Action.

Published in:

Growth Factors, 1999, v. 17, n. 2, p. 81, doi. 10.3109/08977199909103518

By:

Fukada, Toshiyuki;
Yoshida, Yuichi;
Nishida, Keigo;
Ohtani, Takuya;
Shirogane, Takahiro;
Hibi, Masahiko;
Hirano, Toshio

Publication type:

Article

Zinc finger gene fez?like functions in the formation of subplate neurons and thalamocortical axons.

Published in:

Developmental Dynamics, 2004, v. 230, n. 3, p. 546

By:

Tustomu Hirata;
Yoko Suda;
Kazuki Nakao;
Masahiro Narimatsu;
Toshio Hirano;
Masahiko Hibi

Publication type:

Article

Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.

Published in:

Oncogene, 2003, v. 22, n. 10, p. 1546, doi. 10.1038/sj.onc.1206284

By:

Yamasaki, Satoru;
Nishida, Keigo;
Yoshida, Yuichi;
Itoh, Motoyuki;
Hibi, Masahiko;
Hirano, Toshio

Publication type:

Article

The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway.

Published in:

Oncogene, 2001, v. 20, n. 27, p. 3464, doi. 10.1038/sj.onc.1204461

By:

Abe, Koji;
Hirai, Manabu;
Mizuno, Katsunori;
Higashi, Natsuko;
Sekimoto, Toshihiro;
Miki, Tokuhiko;
Hirano, Toshio;
Nakajima, Koichi

Publication type:

Article

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.

Published in:

Oncogene, 2000, v. 19, n. 21, p. 2548, doi. 10.1038/sj.onc.1203551

By:

Hirano, Toshio;
Ishihara, Katsuhiko;
Hibi, Masahiko

Publication type:

Article

Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1.

Published in:

Oncogene, 1999, v. 18, n. 25, p. 3742, doi. 10.1038/sj.onc.1202708

By:

Kortylewski, Marcin;
Heinrich, Peter C;
Mackiewicz, Andrzej;
Schniertshauer, Ute;
Klingmüller, Ursula;
Nakajima, Koichi;
Hirano, Toshio;
Horn, Friedemann;
Behrmann, Iris

Publication type:

Article

Epidermal Growth Factor Signaling Mediated by Grb2 Associated Binder1 Is Required for the Spatiotemporally Regulated Proliferation of Olig2-Expressing Progenitors in the Embryonic Spinal Cord.

Published in:

Stem Cells, 2007, v. 25, n. 6, p. 1410, doi. 10.1634/stemcells.2006-0584

By:

Hayakawa-Yano, Yoshika;
Nishida, Keigo;
Fukami, Shinichi;
Gotoh, Yukiko;
Hirano, Toshio;
Nakagawa, Toshiyuki;
Shimazaki, Takuya;
Okano, Hideyuki

Publication type:

Article

Renin–angiotensin system inhibitors and the severity of coronavirus disease 2019 in Kanagawa, Japan: a retrospective cohort study.

Published in:

Hypertension Research, 2020, v. 43, n. 11, p. 1257, doi. 10.1038/s41440-020-00535-8

By:

Matsuzawa, Yasushi;
Ogawa, Hisao;
Kimura, Kazuo;
Konishi, Masaaki;
Kirigaya, Jin;
Fukui, Kazuki;
Tsukahara, Kengo;
Shimizu, Hiroyuki;
Iwabuchi, Keisuke;
Yamada, Yu;
Saka, Kenichiro;
Takeuchi, Ichiro;
Hirano, Toshio;
Tamura, Kouichi

Publication type:

Article

Intracellular zinc homeostasis and zinc signaling.

Published in:

Cancer Science, 2008, v. 99, n. 8, p. 1515, doi. 10.1111/j.1349-7006.2008.00854.x

By:

Murakami, Masaaki;
Hirano, Toshio

Publication type:

Article

Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells.

Published in:

Cancer Science, 2007, v. 98, n. 5, p. 692, doi. 10.1111/j.1349-7006.2007.00446.x

By:

Kagara, Naofumi;
Tanaka, Natsumi;
Noguchi, Shinzaburo;
Hirano, Toshio

Publication type:

Article

The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors.

Published in:

Cancer Science, 2003, v. 94, n. 12, p. 1029, doi. 10.1111/j.1349-7006.2003.tb01396.x

By:

Nishida, Keigo;
Hirano, Toshio

Publication type:

Article

Revisiting the 1986 molecular cloning of interleukin 6.

Published in:

Frontiers in Immunology, 2014, v. 5, p. 1, doi. 10.3389/fimmu.2014.00456

By:

Toshio Hirano

Publication type:

Article

The molecular mechanisms of chronic inflammation development.

Published in:

Frontiers in Immunology, 2012, v. 3, p. 1, doi. 10.3389/fimmu.2012.00323

By:

Murakami, Masaaki;
Hirano, Toshio

Publication type:

Article

The Molecular Mechanisms of Chronic Inflammation Development.

Published in:

Frontiers in Immunology, 2012, v. 3, p. 1, doi. 10.3389/fimmu.2012.00323

By:

Murakami, Masaaki;
Hirano, Toshio

Publication type:

Article

Signal Transduction through IL-6 Receptor: Involvement of Multiple Protein Kinases, Stat Factors, and a Novel H7-sensitive Pathwaya.

Published in:

Annals of the New York Academy of Sciences, 1995, v. 762, n. 1, p. 55, doi. 10.1111/j.1749-6632.1995.tb32314.x

By:

NAKAJIMA, KOICHI;
MATSUDA, TADASHI;
FUJITANI, YOSHIO;
KOJIMA, HIROTADA;
YAMANAKA, YOJIRO;
NAKAE, KAZUTO;
TAKEDA, TAKASHI;
HIRANO, TOSHIO

Publication type:

Article

Zinc is a novel intracellular second messenger.

Published in:

Journal of Cell Biology, 2007, v. 177, n. 4, p. 637, doi. 10.1083/jcb.200702081

By:

Yamasaki, Satoru;
Sakata-Sogawa, Kumiko;
Hasegawa, Aiko;
Suzuki, Tomoyuki;
Kabu, Koki;
Sato, Emi;
Kurosaki, Tomohiro;
Yamashita, Susumu;
Tokunaga, Makio;
Nishida, Keigo;
Hirano, Toshio

Publication type:

Article

STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension.

Published in:

Journal of Cell Biology, 2004, v. 166, n. 7, p. 975, doi. 10.1083/jcb.200403110

By:

Miyagi, Chiemi;
Yamashita, Susumu;
Ohba, Yusuke;
Yoshizaki, Hisayoshi;
Matsuda, Michiyuki;
Hirano, Toshio

Publication type:

Article

IL-6 in inflammation, autoimmunity and cancer.

Published in:

International Immunology, 2021, v. 33, n. 3, p. 127, doi. 10.1093/intimm/dxaa078

By:

Hirano, Toshio

Publication type:

Article

V- ABL does not abolish IL-6 requirement by murine plasmacytoma cells.

Published in:

International Journal of Cancer, 1991, v. 48, n. 2, p. 234, doi. 10.1002/ijc.2910480214

By:

Sugiyama, Hiroyuki;
Wiener, Francis;
Babonits, Magda;
Silva, Santiago;
Hirano, Toshio;
Kishimoto, Tadamitsu;
Klein, George

Publication type:

Article

STAT3 orchestrates contradictory signals in cytokine-induced G<sub>1</sub> to S cell-cycle transition.

Published in:

EMBO Journal, 1998, v. 17, n. 22, p. 6670, doi. 10.1093/emboj/17.22.6670

By:

Fukada, Toshiyuki;
Ohtani, Takuya;
Yoshida, Yuichi;
Shirogane, Takahiro;
Nishida, Keigo;
Nakajima, Koichi;
Hibi, Masahiko;
Hirano, Toshio

Publication type:

Article

Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1.

Published in:

EMBO Journal, 1997, v. 16, n. 23, p. 7067, doi. 10.1093/emboj/16.23.7067

By:

Sekimoto, Toshihiro;
Imamoto, Naoko;
Nakajima, Koichi;
Hirano, Toshio;
Yoneda, Yoshihiro

Publication type:

Article

Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6.

Published in:

EMBO Journal, 1997, v. 16, n. 17, p. 5345, doi. 10.1093/emboj/16.17.5345

By:

Ihara, Sayoko;
Nakajima, Koichi;
Fukada, Toshiyuki;
Hibi, Masahiko;
Nagata, Satoshi;
Hirano, Toshio;
Fukui, Yasuhisa

Publication type:

Article

How COVID-19 induces cytokine storm with high mortality.

Published in:

Inflammation & Regeneration, 2020, v. 40, n. 1, p. N.PAG, doi. 10.1186/s41232-020-00146-3

By:

Hojyo, Shintaro;
Uchida, Mona;
Tanaka, Kumiko;
Hasebe, Rie;
Tanaka, Yuki;
Murakami, Masaaki;
Hirano, Toshio

Publication type:

Article

Signal TransductionThrough Cytokine Receptors.

Published in:

International Reviews of Immunology, 1998, v. 17, n. 1-4, p. 75, doi. 10.3109/08830189809084488

By:

Hibi, Masahiko;
Hirano, Toshio

Publication type:

Article

Interleukin 6 and its Receptor: Ten Years Later.

Published in:

International Reviews of Immunology, 1998, v. 16, n. 3/4, p. 249, doi. 10.3109/08830189809042997

By:

Hirano, Toshio

Publication type:

Article

Current Concepts of B Cell Modulation.

Published in:

International Reviews of Immunology, 1989, v. 5, n. 2, p. 97, doi. 10.3109/08830188909061976

By:

Matsuda, Tadashi;
Yamasaki, Katsuhiko;
Taga, Tetsuya;
Hirano, Toshio;
Kishimoto, Tadamitsu

Publication type:

Article

Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK.

Published in:

Oncogene, 1997, v. 14, n. 19, p. 2273, doi. 10.1038/sj.onc.1201071

By:

Takahashi-Tezuka, Mariko;
Hibi, Masahiko;
Fujitani, Yoshio;
Fukada, Toshiyuki;
Yamaguchi, Takuya;
Hirano, Toshio

Publication type:

Article

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT.

Published in:

Oncogene, 1997, v. 14, n. 7, p. 751, doi. 10.1038/sj.onc.1200907

By:

Fujitani, Yoshio;
Hibi, Masahiko;
Fukada, Toshiyuki;
Takahashi-Tezuka, Mariko;
Yoshida, Hideyuki;
Yamaguchi, Takuya;
Sugiyama, Kenji;
Yamanaka, Yojiro;
Nakajima, Koichi;
Hirano, Toshio

Publication type:

Article

IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation.

Published in:

International Immunology, 2013, v. 25, n. 5, p. 319, doi. 10.1093/intimm/dxs158

By:

Lee, Jihye;
Nakagiri, Tomoyuki;
Kamimura, Daisuke;
Harada, Masaya;
Oto, Takahiro;
Susaki, Yoshiyuki;
Shintani, Yasushi;
Inoue, Masayoshi;
Miyoshi, Shinichiro;
Morii, Eiichi;
Hirano, Toshio;
Murakami, Masaaki;
Okumura, Meinoshin

Publication type:

Article

Zinc suppresses Th17 development via inhibition of STAT3 activation.

Published in:

International Immunology, 2010, v. 22, n. 5, p. 375, doi. 10.1093/intimm/dxq017

By:

Kitabayashi, Chika;
Fukada, Toshiyuki;
Kanamoto, Minoru;
Ohashi, Wakana;
Hojyo, Shintaro;
Atsumi, Toru;
Ueda, Naoko;
Azuma, Ichiro;
Hirota, Hiroshi;
Murakami, Masaaki;
Hirano, Toshio

Publication type:

Article

IL-6 positively regulates Foxp3+CD8+ T cells in vivo.

Published in:

International Immunology, 2010, v. 22, n. 2, p. 129, doi. 10.1093/intimm/dxp119

By:

Nakagawa, Takayuki;
Tsuruoka, Mineko;
Ogura, Hideki;
Okuyama, Yuko;
Arima, Yasunobu;
Hirano, Toshio;
Murakami, Masaaki

Publication type:

Article

IFN-{gamma} expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death.

Published in:

International Immunology, 2009, v. 21, n. 1, p. 73, doi. 10.1093/intimm/dxn125

By:

Toru Atsumi;
Masae Sato;
Daisuke Kamimura;
Arisa Moroi;
Yoichiro Iwakura;
Ulrich A. K. Betz;
Akihiko Yoshimura;
Mika Nishihara;
Toshio Hirano;
Masaaki Murakami

Publication type:

Article

Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation.

Published in:

International Immunology, 2008, v. 20, n. 6, p. 783, doi. 10.1093/intimm/dxn036

By:

Gui-Hua Jin;
Toshio Hirano;
Masaaki Murakami

Publication type:

Article

IL-6–gp130–STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state.

Published in:

International Immunology, 2007, v. 19, n. 6, p. 695, doi. 10.1093/intimm/dxm045

By:

Nishihara, Mika;
Ogura, Hideki;
Ueda, Naoko;
Tsuruoka, Mineko;
Kitabayashi, Chika;
Tsuji, Fumio;
Aono, Hiroyuki;
Ishihara, Katsuhiko;
Huseby, Eric;
Betz, Ulrich A. K.;
Murakami, Masaaki;
Hirano, Toshio

Publication type:

Article

CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4.

Published in:

International Immunology, 2006, v. 18, n. 9, p. 1397, doi. 10.1093/intimm/dxl073

By:

Naoko Ueda;
Hiroko Kuki;
Daisuke Kamimura;
Shinichiro Sawa;
Kenichiro Seino;
Takuya Tashiro;
Ken-ichi Fushuku;
Masaru Taniguchi;
Toshio Hirano;
Masaaki Murakami

Publication type:

Article

The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis.

Published in:

International Immunology, 2004, v. 16, n. 3, p. 455, doi. 10.1093/intimm/dxh045

By:

Katsuhiko Ishihara;
Shin-ichiro Sawa;
Hideto Ikushima;
Seiichi Hirota;
Toru Atsumi;
Daisuke Kamimura;
Sung-Joo Park;
Masaaki Murakami;
Yukihiko Kitamura;
Yoichiro Iwakura;
Toshio Hirano

Publication type:

Article

Stage-specific expression of mouse BST-1/BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor.

Published in:

International Immunology, 1996, v. 8, n. 9, p. 1395, doi. 10.1093/intimm/8.9.1395

By:

Katsuhiko Ishihara;
Yoshiko Kobune;
Yoshiki Okuyama;
Motoyuki Itoh;
Byung O. K. Lee;
Osamu Muraoka;
Toshio Hirano

Publication type:

Article

A new interleukin with pleiotropic activities.

Published in:

BioEssays, 1988, v. 9, n. 1, p. 11, doi. 10.1002/bies.950090104

By:

Kishimoto, Tadamitsu;
Hirano, Toshio

Publication type:

Article

HIV-induced B Cell Stimulatory Factor 2/Interleukin-6 (BSF2/IL6) Production<sup>a</sup>.

Published in:

Annals of the New York Academy of Sciences, 1989, v. 557, n. 1, p. 521, doi. 10.1111/j.1749-6632.1989.tb24052.x

By:

NAKAJIMA, KOICHI;
MARTINEZ-MAZA, OTONIEL;
HIRANO, TOSHIO;
BREEN, ELIZABETH C.;
NISHANIAN, PARUNAG G.;
SALAZAR-GONZALEZ, JESUS F.;
FAHEY, JOHN L.;
KISHIMOTO, TADAMITSU

Publication type:

Article

Molecular Regulation of the Human Immunoglobulin γ1 Heavy Chain Gene by IL-6.

Published in:

Annals of the New York Academy of Sciences, 1989, v. 557, n. 1, p. 552, doi. 10.1111/j.1749-6632.1989.tb24063.x

By:

RAYNAL, MARIE-CECILE;
HIRANO, TOSHIO;
MAYER, LLOYD;
KISHIMOTO, TADAMITSU;
CHEN-KIANGa, SELINA

Publication type:

Article

Zinc homeostasis and signaling in health and diseases.

Published in:

Journal of Biological Inorganic Chemistry (JBIC), 2011, v. 16, n. 7, p. 1123, doi. 10.1007/s00775-011-0797-4

By:

Fukada, Toshiyuki;
Yamasaki, Satoru;
Nishida, Keigo;
Murakami, Masaaki;
Hirano, Toshio

Publication type:

Article