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- Title
Use of fertility drugs and risk of ovarian cancer.
- Authors
Parazzini, Fabio; Pelucchi, Claudio; Negri, Eva; Franceschi, Silvia; Talamini, Renato; Montella, Maurizio; La Vecchia, Carlo; Parazzini, F; Pelucchi, C; Negri, E; Franceschi, S; Talamini, R; Montella, M; La Vecchia, C
- Abstract
<bold>Background: </bold>The potential association between fertility drugs and risk of ovarian cancer has been analysed using data from a case-control study conducted between January 1992 and September 1999 in four Italian areas.<bold>Methods: </bold>Cases were 1031 women (median age 56, range 18-79 years) with incident, histologically confirmed epithelial ovarian cancer. Controls were 2411 women (median age 57, range 17-79 years) residing in the same geographical areas and admitted to the same network of hospitals for cases for a wide spectrum of acute, non neoplastic, non hormone-related conditions.<bold>Results: </bold>A total of 15 cases and 26 controls reported use of fertility drugs. The corresponding odds ratio (OR) was 1.3 (95% confidence interval 0.7-2.5). The OR was 1.2 for women reporting last use <25 years before interview and 1.3 for >25 years.<bold>Conclusions: </bold>Considering calendar year at use, the OR was non-significantly above unity for women reporting fertility drug use after 1970. The OR was 0.6 among nulliparous women and 1.9 among parous ones.
- Publication
Human Reproduction, 2001, Vol 16, Issue 7, p1372
- ISSN
0268-1161
- Publication type
Academic Journal
- DOI
10.1093/humrep/16.7.1372