Response to the Comment on "Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466,224 UK Biobank Participants".

Ling, Yitong; Yuan, Shiqi; Huang, Xiaxuan; Xu, Anding; Lyu, Jun

The article responds to a comment on a study about the associations of folate/folic acid supplementation and dementia risk in 466,224 UK Biobank participants. The authors clarify that the group with less dementia, which includes a high proportion of white females with college degrees, actually reflects high levels of deprivation, not high socioeconomic status. They also address the imbalance in sample sizes among the groups and the limitations of the study, emphasizing the need for further research on the impact of other supplements on dementia risk. The study found a significant interaction effect between folate/folic acid supplementation status and Alzheimer's disease genetic risk score, supporting the accuracy of their results.

IRON supplements; GENETIC risk score; DISEASE risk factors; DIETARY supplements; FOLIC acid

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2024, Vol 79, Issue 11, p1

1079-5006

Academic Journal

10.1093/gerona/glae124