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- Title
Differential Associations Between Two Markers of Probable Sarcopenia and Continuous Orthostatic Hemodynamics in The Irish Longitudinal Study on Ageing.
- Authors
Duggan, Eoin; Murphy, Caoileann H; Knight, Silvin P; Davis, James R C; O'Halloran, Aisling M; Kenny, Rose Anne; Romero-Ortuno, Roman
- Abstract
Background Sarcopenia and orthostatic hypotension are growing age-related health burdens associated with adverse outcomes, including falls. Despite a possible pathophysiological link, the association between the 2 disorders is not well elucidated. We sought to investigate this relationship in The Irish Longitudinal Study on Ageing (TILDA). Methods Data from 2 858 participants at wave 3 of TILDA were analyzed. Probable sarcopenia was defined as per the European Working Group on Sarcopenia in Older People revised definition cutoffs (hand grip strength [HGS] 15 seconds). Participants underwent an active stand orthostatic test with continuous blood pressure (BP) monitoring. Multilevel mixed-effects models, controlling for possible confounders, were used to assess the effect of probable sarcopenia by HGS and 5CST criteria on the change in BP after standing. Results HGS- and 5CST-defined probable sarcopenia were independently associated with an attenuated BP recovery at 10–20 seconds poststand (systolic BP: β −0.54, p <.001; β −0.25, p <.001). On average, those meeting HGS probable sarcopenia criteria had a significantly lower BP at 20, 30, and 40 seconds (differences in systolic BP: −5.01 mmHg, −3.68 mmHg, −2.32 mmHg, p <.05 for all). Those meeting 5CST probable sarcopenia criteria had a significant difference in systolic BP at 20 seconds (−1.94 mmHg, p =.002) but not at 30 or 40 seconds. Conclusion Probable sarcopenia had a significant association with delayed orthostatic BP recovery, with HGS-defined probable sarcopenia having a stronger association than 5CST-defined probable sarcopenia. Results support a modest but significant pathophysiological link between probable sarcopenia and orthostatic hypotension.
- Subjects
SARCOPENIA; HEMODYNAMICS; ORTHOSTATIC hypotension; GRIP strength; LONGITUDINAL method
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2023, Vol 78, Issue 8, p1376
- ISSN
1079-5006
- Publication type
Academic Journal
- DOI
10.1093/gerona/glac243