Disparities in donor heart acceptance between the USA and Europe: clinical implications.

Wayda, Brian; Angleitner, Philipp; Smits, Jacqueline M; Kins, Arne van; Berchtold-Herz, Michael; Pauw, Michel De; Erasmus, Michiel E; Gummert, Jan; Hartyanszky, Istvan; Knezevic, Ivan; Laufer, Guenther; Milicic, Davor; Rega, Filip; Schulze, P Christian; Caeneghem, Olivier van; Khush, Kiran K; Zuckermann, Andreas O

Background and Aims Given limited evidence and lack of consensus on donor acceptance for heart transplant (HT), selection practices vary widely across HT centres in the USA. Similar variation likely exists on a broader scale—across countries and HT systems—but remains largely unexplored. This study characterized differences in heart donor populations and selection practices between the USA and Eurotransplant—a consortium of eight European countries—and their implications for system-wide outcomes. Methods Characteristics of adult reported heart donors and their utilization (the percentage of reported donors accepted for HT) were compared between Eurotransplant (n = 8714) and the USA (n = 60 882) from 2010 to 2020. Predictors of donor acceptance were identified using multivariable logistic regression. Additional analyses estimated the impact of achieving Eurotransplant-level utilization in the USA amongst donors of matched quality, using probability of acceptance as a marker of quality. Results Eurotransplant reported donors were older with more cardiovascular risk factors but with higher utilization than in the USA (70% vs. 44%). Donor age, smoking history, and diabetes mellitus predicted non-acceptance in the USA and, by a lesser magnitude, in Eurotransplant; donor obesity and hypertension predicted non-acceptance in the USA only. Achieving Eurotransplant-level utilization amongst the top 30%–50% of donors (by quality) would produce an additional 506–930 US HTs annually. Conclusions Eurotransplant countries exhibit more liberal donor heart acceptance practices than the USA. Adopting similar acceptance practices could help alleviate the scarcity of donor hearts and reduce waitlist morbidity in the USA.

CARDIOVASCULAR diseases risk factors; HEART transplantation; HEART

European Heart Journal, 2023, Vol 44, Issue 44, p4665

0195-668X

Academic Journal

10.1093/eurheartj/ehad684