The quest for optimal timing of surgery continues Circulation 2009; 119: 2516 - 2525. https://doi.org/10.1161/CIRCULATIONAHA.108.821306 Google Scholar Crossref Search ADS PubMed WorldCat 9 Bohbot Y, Chadha G, Delabre J, Landemaine T, Beyls C, Tribouilloy C. Characteristics and prognosis of patients with significant tricuspid regurgitation. Despite growing refinements in risk stratification of patients with asymptomatic MR, optimal timing for surgery is still to be determined.