Works matching DE "THERAPEUTIC use of oligonucleotides"

Results: 112

Therapeutic potential of antisense oligodeoxynucleotides in downregulating p53 oncogenic mutations in cancers.

Published in:

Biotechnology Letters, 2011, v. 33, n. 2, p. 221, doi. 10.1007/s10529-010-0423-5

By:

Zhigang Xie;
Wee Joo Chng;
Kian Ghee Tay;
Shaw Cheng Liu;
Jianbiao Zhou;
Chien-Shing Chen

Publication type:

Article

Dendrimers for gene delivery - a potential approach for ocular therapy?

Published in:

Journal of Pharmacy & Pharmacology, 2014, v. 66, n. 4, p. 542, doi. 10.1111/jphp.12104

By:

Chaplot, Sahil P.;
Rupenthal, Ilva D.

Publication type:

Article

LNA and α-L-LNA: Towards Therapeutic Applications.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2003, v. 22, n. 5-8, p. 601, doi. 10.1081/NCN-120021963

By:

Wengel, Jesper;
Vester, Birte;
Lundberg, Lars Bo;
Douthwaite, Stephen;
Sørensen, Mads D.;
Ravindra Babu, B.;
Gait, Michael J.;
Arzumanov, Andrey;
Petersen, Michael;
Nielsen, Jakob T.

Publication type:

Article

Combined transfection of Bcl-2 siRNA and miR-15a oligonucleotides enhanced methotrexate-induced apoptosis in Raji cells.

Published in:

Cancer Biology & Medicine, 2013, v. 10, n. 1, p. 16, doi. 10.7497/j.issn.2095-3941.2013.01.003

By:

Li Ding;
Xiao-Mao Hu;
Hong Wu;
Ge-Xiu Liu;
Yang-Jun Gao;
Dong-Mei He;
Yuan Zhang

Publication type:

Article

Do shoot the messenger: Taking aim at RNA to treat genetic skin disorders.

Published in:

Experimental Dermatology, 2017, v. 26, n. 1, p. 22, doi. 10.1111/exd.13218

By:

van Steensel, Maurice A.M.

Publication type:

Article

Efficacy and Safety of Edifoligide, an E2F Transcription Factor Decoy, for Prevention of Vein Graft Failure Following Coronary Artery Bypass Graft Surgery: PREVENT IV: A Randomized Controlled Trial.

Published in:

JAMA: Journal of the American Medical Association, 2005, v. 294, n. 19, p. 2446

By:

Alexander, John H.

Publication type:

Article

Oligonucleotide therapy mitigates disease in spinocerebellar ataxia type 3 mice.

Published in:

2018

By:

Mcloughlin, Hayley S.;
Moore, Lauren R.;
Chopra, Ravi;
Komlo, Robert;
Mckenzie, Megan;
Blumenstein, Kate G.;
Zhao, Hien;
Kordasiewicz, Holly B.;
Shakkottai, Vikram G.;
Paulson, Henry L.

Publication type:

journal article

Antisense Oligonucleotide-Based Therapy for Neuromuscular Disease.

Published in:

Molecules, 2017, v. 22, n. 4, p. 563, doi. 10.3390/molecules22040563

By:

Sardone, Valentina;
Haiyan Zhou;
Muntoni, Francesco;
Ferlini, Alessandra;
Falzarano, Maria Sofia

Publication type:

Article

Therapeutic Oligonucleotides Targeting Liver Disease: TTR Amyloidosis.

Published in:

Molecules, 2015, v. 20, n. 10, p. 17944, doi. 10.3390/molecules201017944

By:

Niemietz, Christoph;
Chandhok, Gursimran;
Schmidt, Hartmut

Publication type:

Article

Generation of Aptamers with an Expanded Chemical Repertoire.

Published in:

Molecules, 2015, v. 20, n. 9, p. 16643, doi. 10.3390/molecules200916643

By:

Diafa, Stella;
Hollenstein, Marcel

Publication type:

Article

Cell-Penetrating Peptides to Enhance Delivery of Oligonucleotide-Based Therapeutics.

Published in:

Biomedicines, 2018, v. 6, n. 2, p. 51, doi. 10.3390/biomedicines6020051

By:

Mcclorey, Graham;
Banerjee, Subhashis

Publication type:

Article

Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects.

Published in:

Biomedicines, 2017, v. 5, n. 3, p. 45, doi. 10.3390/biomedicines5030045

By:

Kruspe, Sven;
Giangrande, Paloma H.

Publication type:

Article

Identification of methylation-silenced genes in colorectal cancer cell lines: Genomic screening using oligonucleotide arrays.

Published in:

Scandinavian Journal of Gastroenterology, 2007, v. 42, n. 12, p. 1486, doi. 10.1080/00365520701491173

By:

Fukutomi, Satoshi;
Seki, Naohiko;
Koda, Keiji;
Miyazaki, Masaru

Publication type:

Article

First-in-human Phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide to exon 4 of the androgen receptor mRNA in patients with castration-resistant prostate cancer.

Published in:

British Journal of Cancer, 2013, v. 109, n. 10, p. 2579, doi. 10.1038/bjc.2013.619

By:

Bianchini, D;
Omlin, A;
Pezaro, C;
Lorente, D;
Ferraldeschi, R;
Mukherji, D;
Crespo, M;
Figueiredo, I;
Miranda, S;
Riisnaes, R;
Zivi, A;
Buchbinder, A;
Rathkopf, D E;
Attard, G;
Scher, H I;
de Bono, J;
Danila, D C

Publication type:

Article

Solid-Phase Synthesis of 2′- O-Methoxyethyl Oligonucleotides Using Dimeric Phosphoramidite Blocks.

Published in:

Bulletin of the Korean Chemical Society, 2016, v. 37, n. 11, p. 1754, doi. 10.1002/bkcs.10962

By:

Yu, Gi Weon;
Kang, Yong Han

Publication type:

Article

Silencing human genetic diseases with oligonucleotide-based therapies.

Published in:

Human Genetics, 2013, v. 132, n. 5, p. 481, doi. 10.1007/s00439-013-1288-1

By:

Martínez, Tamara;
Wright, Natalia;
López-Fraga, Marta;
Jiménez, Ana;
Pañeda, Covadonga

Publication type:

Article

Gapmer Oligonucleotides: Sugar-Modified Wings to Antisense Therapeutics.

Published in:

Trends in Carbohydrate Research, 2015, v. 7, n. 3, p. 28

By:

Rungta, Pallavi;
Mangla, Priyanka;
Sharma, Vivek K.;
Singh, Sunil K.;
Chauhan, Aman;
Masram, Dhanraj T.;
Senapati, Nihar Nalini;
Prasad, Ashok K.

Publication type:

Article

Fomivirsen – a phosphorothioate oligonucleotide for the treatment of CMV retinitis.

Published in:

Ocular Immunology & Inflammation, 1999, v. 7, n. 3/4, p. 189, doi. 10.1076/ocii.7.3.189.4007

By:

de Smet, Marc D.;
Meenken, Christina;
van den Horn, Gerardus J.

Publication type:

Article

Long-Term Efficacy, Safety, and Pharmacokinetics of Drisapersen in Duchenne Muscular Dystrophy: Results from an Open-Label Extension Study.

Published in:

PLoS ONE, 2016, v. 11, n. 9, p. 1, doi. 10.1371/journal.pone.0161955

By:

Goemans, Nathalie M.;
Tulinius, Már;
van den Hauwe, Marleen;
Kroksmark, Anna-Karin;
Buyse, Gunnar;
Wilson, Rosamund J.;
van Deutekom, Judith C.;
de Kimpe, Sjef J.;
Lourbakos, Afrodite;
Campion, Giles

Publication type:

Article

Pharmacokinetics of High-Dose Abetimus Sodium in Normal Subjects With Specific Assessment of Effect on Coagulation.

Published in:

Journal of Clinical Pharmacology, 2008, v. 48, n. 8, p. 909, doi. 10.1177/0091270008319465

By:

Linnik, Matthew D.;
O'Rourke, Anne M.;
Crowther, Mark A.

Publication type:

Article

Long Noncoding RNA CCAT2 Knockdown Suppresses Tumorous Progression by Sponging miR-424 in Epithelial Ovarian Cancer.

Published in:

Oncology Research, 2018, v. 26, n. 2, p. 241, doi. 10.3727/096504017X14953948675412

By:

Fu Hua;
Chang-Hua Li;
Xiao-Gang Chen;
Xiao-Ping Liu

Publication type:

Article

Antisense Oligonucleotide Therapies: The Promise and the Challenges from a Toxicologic Pathologist’s Perspective.

Published in:

Toxicologic Pathology, 2015, v. 43, n. 1, p. 78, doi. 10.1177/0192623314551840

By:

Frazier, Kendall S.

Publication type:

Article

Species-specific Inflammatory Responses as a Primary Component for the Development of Glomerular Lesions in Mice and Monkeys Following Chronic Administration of a Second-generation Antisense Oligonucleotide.

Published in:

Toxicologic Pathology, 2014, v. 42, n. 5, p. 923, doi. 10.1177/0192623313505781

By:

Frazier, Kendall S.;
Sobry, Cécile;
Derr, Victoria;
Adams, Mike J.;
Besten, Cathaline Den;
Kimpe, Sjef De;
Francis, Ian;
Gales, Tracy L.;
Haworth, Richard;
Maguire, Shaun R.;
Mirabile, Rosanna C.;
Mullins, David;
Palate, Bernard;
Doorten, Yolanda Ponstein-Simarro;
Ridings, James E.;
Scicchitano, Marshall S.;
Silvano, Jérémy;
Woodfine, Jennie

Publication type:

Article

Antisense oligonucleotides as therapeutics and their delivery.

Published in:

Current Science (00113891), 2017, v. 112, n. 3, p. 490, doi. 10.18520/cs/v112/i03/490-498

By:

Gurav, Bhagyashree;
Srinivasan, Ganga

Publication type:

Article

Degradation product characterization of therapeutic oligonucleotides using liquid chromatography mass spectrometry.

Published in:

Analytical & Bioanalytical Chemistry, 2018, v. 410, n. 14, p. 3375, doi. 10.1007/s00216-018-1032-8

By:

Elzahar, N. M.;
Magdy, N.;
El-Kosasy, Amira M.;
Bartlett, Michael G.

Publication type:

Article

Abstracts.

Published in:: 2018
Publication type:: Abstract

Abnormal thymic maturation and lymphoproliferation in MRL-Fas<sup>lpr/lpr</sup> mice can be partially reversed by synthetic oligonucleotides: implications for systemic lupus erythematosus and autoimmune lymphoproliferative syndrome.

Published in:

Lupus, 2017, v. 26, n. 7, p. 734, doi. 10.1177/0961203316676381

By:

Ashman, R. F.;
Singh, N.;
Lenert, P. S.

Publication type:

Article

C/D-box snoRNAs form methylating and non-methylating ribonucleoprotein complexes: Old dogs show new tricks.

Published in:

BioEssays, 2017, v. 39, n. 6, p. n/a, doi. 10.1002/bies.201600264

By:

Falaleeva, Marina;
Welden, Justin R.;
Duncan, Marilyn J.;
Stamm, Stefan

Publication type:

Article

Targeting RNA: A Transformative Therapeutic Strategy.

Published in:

CTS: Clinical & Translational Science, 2019, v. 12, n. 2, p. 98, doi. 10.1111/cts.12624

By:

Yin, Wei;
Rogge, Mark

Publication type:

Article

Extended gene analysis can increase specificity of neonatal screening for cystic fibrosis.

Published in:

Acta Paediatrica, 2006, v. 95, n. 11, p. 1424, doi. 10.1080/08035250600781846

By:

Mérelle, Marieke E.;
Scheffer, Hans;
De Jong, Debora;
Dankert-Roelse, Jeannette E.

Publication type:

Article

An evaluation of oligonucleotide-based therapeutic strategies for polyQ diseases.

Published in:: BMC Molecular Biology, 2012, v. 13, n. 1, p. 6, doi. 10.1186/1471-2199-13-6
Publication type:: Article

Duchenne muscular dystrophy caused by a frame-shift mutation in the acceptor splice site of intron 26.

Published in:

2016

By:

Meregalli, Mirella;
Maciotta, Simona;
Angeloni, Valentina;
Torrente, Yvan

Publication type:

Case Study

Intrathecal administration of nusinersen in adolescent and adult SMA type 2 and 3 patients.

Published in:

Journal of Neurology, 2019, v. 266, n. 1, p. 183, doi. 10.1007/s00415-018-9124-0

By:

Wurster, Claudia D.;
Winter, Benedikt;
Wollinsky, Kurt;
Ludolph, Albert C.;
Uzelac, Zeljko;
Witzel, Simon;
Schocke, Michael;
Schneider, Ralf;
Kocak, Tugrul

Publication type:

Article

Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2014, v. 73, n. 2, p. 343, doi. 10.1007/s00280-013-2362-z

By:

Jeong, Woondong;
Rapisarda, Annamaria;
Park, Sook;
Kinders, Robert;
Chen, Alice;
Melillo, Giovanni;
Turkbey, Baris;
Steinberg, Seth;
Choyke, Peter;
Doroshow, James;
Kummar, Shivaani

Publication type:

Article

Make or break for first splice-modulating agents.

Published in:

Nature Reviews Drug Discovery, 2013, v. 12, n. 11, p. 813, doi. 10.1038/nrd4151

By:

Mullard, Asher

Publication type:

Article

RNA therapeutics: beyond RNA interference and antisense oligonucleotides.

Published in:

Nature Reviews Drug Discovery, 2012, v. 11, n. 2, p. 125, doi. 10.1038/nrd3625

By:

Kole, Ryszard;
Krainer, Adrian R.;
Altman, Sidney

Publication type:

Article

In this issue.

Published in:: Nature Reviews Drug Discovery, 2011, v. 10, n. 8, p. 557, doi. 10.1038/nrd3513
Publication type:: Article

Targeting RNA to treat neuromuscular disease.

Published in:

2011

By:

Muntoni, Francesco;
Wood, Matthew J. A.

Publication type:

journal article

Therapeutic potential of Toll-like receptor 9 activation.

Published in:

Nature Reviews Drug Discovery, 2006, v. 5, n. 6, p. 471, doi. 10.1038/nrd2059

By:

Krieg, Arthur M.

Publication type:

Article

Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins.

Published in:

2001

By:

Gautschi, Oliver;
Tschopp, Stefan;
Olie, Robert A.;
Leech, Sian H.;
Simoes-Wust, A. Paula;
Ziegler, Annemarie;
Baumann, Bettina;
Odermatt, Bernhard;
Hall, Jonathan;
Stahel, Rolf A.;
Zangemeister-Wittke, Uwe;
Gautschi, O;
Tschopp, S;
Olie, R A;
Leech, S H;
Simões-Wüst, A P;
Ziegler, A;
Baumann, B;
Odermatt, B;
Hall, J

Publication type:

journal article

Advances in the delivery of RNA therapeutics: from concept to clinical reality.

Published in:

Genome Medicine, 2017, v. 9, p. 1, doi. 10.1186/s13073-017-0450-0

By:

Kaczmarek, James C.;
Kowalski, Piotr S.;
Anderson, Daniel G.

Publication type:

Article

Aptamers as biomarkers for neurological disorders. Proof of concept in transgenic mice.

Published in:

PLoS ONE, 2018, v. 13, n. 1, p. 1, doi. 10.1371/journal.pone.0190212

By:

Lecocq, Soizic;
Spinella, Katia;
Dubois, Bruno;
Lista, Simone;
Hampel, Harald;
Penner, Gregory

Publication type:

Article

RNA in the spotlight: the dawn of RNA therapeutics in the treatment of human disease.

Published in:

Cardiovascular Research, 2017, v. 113, n. 12, p. e43, doi. 10.1093/cvr/cvx170

By:

Stellos, Konstantinos

Publication type:

Article

Protein and oligonucleotide delivery systems for vaginal microbicides against viral STIs.

Published in:

Cellular & Molecular Life Sciences, 2015, v. 72, n. 3, p. 469, doi. 10.1007/s00018-014-1756-3

By:

Steinbach, Jill

Publication type:

Article

Development of antisense oligonucleotide (ASO) technology against Tgf-β signaling to prevent scarring during flexor tendon repair.

Published in:

Journal of Orthopaedic Research, 2015, v. 33, n. 6, p. 859, doi. 10.1002/jor.22890

By:

Loiselle, Alayna E.;
Yukata, Kiminori;
Geary, Michael B.;
Kondabolu, Sirish;
Shi, Shanshan;
Jonason, Jennifer H.;
Awad, Hani A.;
O'Keefe, Regis J.

Publication type:

Article

Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotides.

Published in:

Journal of Nanobiotechnology, 2009, v. 7, p. 1, doi. 10.1186/1477-3155-7-1

By:

Sirsi, Shashank R.;
Schray, Rebecca C.;
Wheatley, Margaret A.;
Lutz, Gordon J.

Publication type:

Article

Human laminopathies: nuclei gone genetically awry.

Published in:

2006

By:

Capell, Brian C.;
Collins, Francis S.

Publication type:

journal article

Design and Synthesis of LNA-Based Mercaptoacetamido-Linked Nucleoside Dimers.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2013, v. 32, n. 5, p. 256, doi. 10.1080/15257770.2013.783218

By:

Sharma, VivekK.;
Singh, SunilK.;
Bohra, Kapil;
L., ChandraShekhar Reddy;
Khatri, Vinod;
Olsen, CarlE.;
Prasad, AshokK.

Publication type:

Article

Antisense Oligonucleotide Therapy for Spinocerebellar Ataxias: Good News for Terrible Diseases.

Published in:

Movement Disorders Clinical Practice, 2018, v. 5, n. 4, p. 402, doi. 10.1002/mdc3.12627

By:

Teive, Hélio A. G.;
Camargo, Carlos Henrique F.;
Munhoz, Renato Puppi

Publication type:

Article

Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol–conjugated heteroduplex oligonucleotide in mice.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-93666-y

By:

Suzuki, Motohiro;
Ishibashi, Satoru;
Iwasawa, Eri;
Oguma, Takahiro;
Saito, Yasuhiro;
Li, Fuying;
Otsu, Shinichi;
Ichinose, Keiko;
Yoshioka, Kotaro;
Nagata, Tetsuya;
Yokota, Takanori

Publication type:

Article