We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
P458 Changes of pulmonary vasoactive factors and its relation with pulmonary arterial hypertension in patients with high altitude pulmonary edema.
- Authors
Zhou, Q
- Abstract
Objective: To assess the changes of pulmonary vasoactive factors and its relation with pulmonary arterial hypertension (PAH) in patients with high altitude pulmonary edema (HAPE).Methods: The levels of plasma intermedin(IMD), adrenomedulin(ADM), endothelin-1 (ET-1), partial pressure of oxygen in artery blood (PaO2), and mean pulmonary arterial pressure (mPAP) were measured in 22 patients with HAPE before treatment and after cure.In addition,the upper mentioned parameters were meated in 30 healthy peoples.Results: Before treatment,levels of IMD, ADM, ET-1, and mPAP [(174.23±17.44)pg/mL, (77.45±6.87)pg/mL, (93.6±10.22)ng/L, (46.51±7.20)mm Hg, respectively] were markedly higher,and PaO2 [(33.82±5.66)mm Hg] was lower in HAPE patients than those in the the normal control subjects [(62.76±10.60)pg/mL, (22.04±3.15)pg/mL, (35.52±4.52)ng/L, (20.14±3.34)mm Hg, (69.27±3.35)mm Hg, respectively] (all P0.05).Conclusion: IMD, ADM and ET-1 may play important roles in mechanism of PAH in HAPE. Imbalance of these factors had great effects on the development of hypoxic pulmonary hypertasion.
- Subjects
PULMONARY edema; HYPERTENSION; PATIENTS; MSH (Hormone); ENDOTHELINS; COHORT analysis
- Publication
Cardiovascular Research, 2014, Vol 103, Issue suppl_1, pS84
- ISSN
0008-6363
- Publication type
Academic Journal
- DOI
10.1093/cvr/cvu091.136