Ligand-dependent activation of ERβ lowers blood pressure and attenuates cardiac hypertrophy in ovariectomized spontaneously hypertensive rats.

Jazbutyte, Virginija; Arias-Loza, Paula Anahi; Kai Hu; Widder, Julian; Govindaraj, Vijayakumar; von Poser-Klein, Christine; Bauersachs, Johann; Fritzemeier, Karl-Heinrich; Hegele-Hartung, Christa; Neyses, Ludwig; Ertl, Georg; Pelzer, Theo

Aims: The biological effects of oestrogens are mediated by two different oestrogen receptor (ER) subtypes, ERα and ERβ, which might play different, redundant, or opposing roles in cardiovascular disease. Previously, we have shown that the selective ERα agonist 16α-LE2 improves vascular relaxation, attenuates cardiac hypertrophy, and increases cardiac output without lowering elevated blood pressure in spontaneously hypertensive rats (SHR). Because ERβ-deficient mice exhibit elevated blood pressure and since the ERβ agonist 8β-VE2 attenuated hypertension in aldosterone-salt-treated rats, we have now tested the hypothesis that the isotype-selective ERβ agonist 8β-VE2 might be capable of lowering elevated blood pressure in ovariectomized SHR.

ESTROGEN receptors; CARDIOVASCULAR diseases; CARDIAC hypertrophy; HYPERTENSION; ANIMAL models in research; BLOOD pressure; LABORATORY rats

Cardiovascular Research, 2008, Vol 77, Issue 4, p774

0008-6363

Academic Journal

10.1093/cvr/cvm081