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- Title
Regulation of swelling-activated Cl− current by angiotensin II signalling and NADPH oxidase in rabbit ventricle.
- Authors
Ren, Zuojun; Raucci Jr., Frank J.; Browe, David M.; Baumgarten, Clive M.
- Abstract
Aims: We assessed whether hypoosmotic swelling of cardiac myocytes activates volume-sensitive Cl− current (ICl,swell) via the angiotensin II (AngII)-reactive oxygen species (ROS) signalling cascade. The AngII-ROS pathway previously was shown to elicit ICl,swell upon mechanical stretch of β1D integrin. Integrin stretch and osmotic swelling are, however, distinct stimuli. For example, blocking Src kinases stimulates swelling-induced but inhibits stretch-induced ICl,swell.
- Subjects
ANGIOTENSINS; REACTIVE oxygen species; MYOCARDIUM; MUSCLE cells; EDEMA; LABORATORY rabbits
- Publication
Cardiovascular Research, 2008, Vol 77, Issue 1, p73
- ISSN
0008-6363
- Publication type
Academic Journal
- DOI
10.1093/cvr/cvm031