Results
Title

Regulation of swelling-activated Cl− current by angiotensin II signalling and NADPH oxidase in rabbit ventricle.

Authors

Ren, Zuojun; Raucci Jr., Frank J.; Browe, David M.; Baumgarten, Clive M.

Abstract

Aims: We assessed whether hypoosmotic swelling of cardiac myocytes activates volume-sensitive Cl− current (ICl,swell) via the angiotensin II (AngII)-reactive oxygen species (ROS) signalling cascade. The AngII-ROS pathway previously was shown to elicit ICl,swell upon mechanical stretch of β1D integrin. Integrin stretch and osmotic swelling are, however, distinct stimuli. For example, blocking Src kinases stimulates swelling-induced but inhibits stretch-induced ICl,swell.

Subjects

ANGIOTENSINS; REACTIVE oxygen species; MYOCARDIUM; MUSCLE cells; EDEMA; LABORATORY rabbits

Publication

Cardiovascular Research, 2008, Vol 77, Issue 1, p73

ISSN

0008-6363

Publication type

Academic Journal

DOI

10.1093/cvr/cvm031