Title: Risk factors for the development of Stevens–Johnson syndrome/toxic epidermal necrolysis following drug administration: a systematic review and meta-analysis.
Authors: Fathima, Samaah; Grainge, Matthew J; Wainman, Hannah; Swiderski, Mikolaj; Gran, Sonia
Abstract: The article discusses the risk factors associated with the development of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) following drug administration. SJS and TEN are rare severe cutaneous adverse reactions primarily caused by medications, with common culprits being antibiotics and antiepileptics. The study conducted a systematic review and meta-analysis to identify risk factors for SJS/TEN development, highlighting male gender and HIV infection as significant risk factors. The review emphasizes the need for further large-scale studies to better understand and prevent the occurrence of SJS/TEN.
Subjects: DRUG side effects; NOSOLOGY; CHRONIC kidney failure; DRUG eruptions; CHRONIC obstructive pulmonary disease; AGE factors in cancer
Publication: Clinical & Experimental Dermatology, 2024, Vol 49, Issue 12, p1699
ISSN: 0307-6938
Publication type: Academic Journal
DOI: 10.1093/ced/llae183

Risk factors for the development of Stevens–Johnson syndrome/toxic epidermal necrolysis following drug administration: a systematic review and meta-analysis.

Fathima, Samaah; Grainge, Matthew J; Wainman, Hannah; Swiderski, Mikolaj; Gran, Sonia